Frage 1
Frage
Which of the following is not safe during pregnancy?
Frage 2
Frage
Which of the following metabolic changes is not seen with use of loop diuretics?
Antworten
-
Decrease in Ca
-
Decrease in K
-
Increase in Mg
-
Increase in Glucose
Frage 3
Frage
Which of the following is not a side effect of thiazides?
Antworten
-
Hyponatremia
-
Metabolic alkalosis
-
Hypouricemia
-
Sexual dysfunction
Frage 4
Frage
Which of the following G IIb/IIIa receptor antagonists has a long half life and is irreversible?
Antworten
-
ASA
-
Tirofiban
-
Abciximab
-
Eptifibatide
Frage 5
Frage
Which of the following is not a side effect of osmostic diuretics?
Frage 6
Frage
Which of the following is a characteristic of LMWH?
Antworten
-
Low bioavailability
-
Monitored with PTT
-
Inexpensive
-
Renally excreted
Frage 7
Frage
Which of the following is not a side effect of Aliskiren?
Antworten
-
Decrease in uric acid
-
Diarrhea
-
Abdominal pain
-
Angioedema
Frage 8
Frage
Which of the following is not correct regarding eplerenone?
Antworten
-
It is more expensive than spironolactone
-
Less endocrine-related side effects than spironolactone
-
Lower chance of hyperkalemia
-
Higher affinity for aldosterone receptors
Frage 9
Frage
Which of the following is not a side effect of ACEI?
Antworten
-
Cough
-
Hypotension
-
Gynecomastia
-
Hyperkalemia
Frage 10
Frage
Acetazolamide causes metabolic alkalosis because you excrete bicarbonate, and therefore it is best to administer this diuretic to metabolic acidic patients.
Frage 11
Frage
Which of the following are better to avoid with use of potassium-sparing diuretics?
Antworten
-
ACEI
-
Lithium
-
Eplerenone
-
Amiloride
Frage 12
Frage
Choose which of the following you would administer to a CKD patient
Frage 13
Frage
Which of the following diuretics act on the distal convoluted tubule to block sodium reabsorption?
Antworten
-
Aldosterone antagonists
-
Thiazides
-
Loop diuretics
-
CAIs
Frage 14
Frage
You always have drug interactions with NSAIDS with use of diurectics because they inhibit prostaglandins which antagonizes the action of diurectics
Frage 15
Frage
Which diuretic would you not want to use in a patient who has gout?
Frage 16
Frage
How does Conivaptan promote free water diuresis?
Antworten
-
By stimulating cGMP resulting in vascular smooth muscle relaxation
-
By being excreted unchanged and causing water to be retained within the proximal tubule and descending loop of Henle due to the freely permeable water
-
By blocking the epithelial sodium channels on principal cells and cause sodium excretion
-
By antagonizing vasopressing
Frage 17
Frage
Lisinopril antagonizes the AT1 receptor
Frage 18
Frage
Which of the following metabolic changes would you see with the use of a thiazide?
Antworten
-
Increase Mg
-
Increase Ca
-
Decrease glucose
-
Increase in potassium
Frage 19
Frage
Hydrochlorthiazide is used more than chlorthalidone because it is more potent and research has shown that it produces a greater reduction in systolic blood pressure.
Frage 20
Frage
In which of the following conditions would not benefit from the use of vasopressin receptor antagonists?
Antworten
-
Urinary frequency
-
CHF
-
cirrhosis
-
SIADH
Frage 21
Frage
Which of the following is a side effect Bosentan?
Antworten
-
Epistaxis
-
Visual disturbances
-
Liver cirrhosis
-
Dyspepsia
Frage 22
Frage
Which of the following would require careful dosing in a renal failure patient?
Antworten
-
Fondaparinux
-
Abciximab
-
Warfarin
-
Argatraban
Frage 23
Frage
Which of the following drug combinations would not be beneficial?
Frage 24
Frage
Liver toxicity is a side effect of tolvaptan?
Frage 25
Frage
Which of the following have short half-lives
Antworten
-
UFH
-
Warfarin
-
ASA
-
Fondaparinux
-
Vorapaxar
-
Abciximab
-
Eptifibatide
-
Tirofiban
Frage 26
Frage
Why do we need to overlap warfarin and heparin or LMWH in a patient with a new VTE?
Antworten
-
Because you want to deactivate antithrombin
-
It takes about 5 days to replace activated clotting factors with dysfunctional clotting factors
-
It takes about 5 days to replace Protein C and Protein S
-
You should never overlap warfarin with LMWH or UFH
Frage 27
Frage
Which of the following antiplatelets can cause dyspnea?
Antworten
-
Prasugrel
-
Ticagrelor
-
Clopidogrel
-
Ticlopidine
Frage 28
Frage
Which of the following prostanoids can cause epistaxis?
Antworten
-
Epoprosternol
-
Iloprost
-
Treprostinil (Remodulin)
-
Treprostinil (Tyvaso)
Frage 29
Frage
Which of the following is safe during lactation?
Antworten
-
Dabigatran
-
Direct X inhibitors
-
Warfarin
-
Indirect X inhibitors
Frage 30
Frage
Which of the following antiplatelets can be used when a patient has had a cardiac event while taking clopidogrel?
Antworten
-
Ticlopidine
-
Ticagrelor
-
Prasugrel
-
UFH
Frage 31
Frage
Which of the following antiplatelets is used with aspirin in post-ACS patients?
Antworten
-
Ticagrelor
-
Ticlopidine
-
Prasugrel
-
Clopidogrel
Frage 32
Frage
Liver toxicity is a side effect of conivaptan
Frage 33
Frage
Which of the following antiplatelets is hardly used in clinical practice and can cause neutropenia?
Antworten
-
Ticagrelor
-
Clopidogrel
-
Prasugrel
-
Ticlopidine
Frage 34
Frage
Which of the following antiplatelets is contraindicated for patients with a history of stroke/TIA?
Antworten
-
Prasugrel
-
Ticagrelor
-
Clopidogrel
-
Ticlopidine
Frage 35
Frage
Ranolazine can be used ONLY in acute angina attacks
Frage 36
Frage
It is important to hold indirect factor X inhibitors for at least 48 hours
Frage 37
Frage
Why is it important to place a patient who develops HIT on another anticoagulant?
Antworten
-
To decrease the platelet count.
-
To prevent a prothrombotic condition
-
To prevent bleeding.
-
To induce a prothrombotic condition
Frage 38
Frage
Which of the following is not part of the treatment for HIT?
Antworten
-
Stop heparin products
-
Stop warfarin until platelet count is above 150,000
-
Use alternative anticoagulants
-
Give a high dose of warfarin when restarting
Frage 39
Frage
Which of the following drugs can cause serious cardiovascular and thromboemolic events if dose and hemoglobin range is not taken into account?
Antworten
-
Calcitriol
-
ERAs
-
ESAs
-
Dopamine
Frage 40
Frage
Which of the following is not a characteristic of argatraban?
Frage 41
Frage
Which of the following is absolutely not safe during pregnancy?
Antworten
-
Warfarin
-
Heparin/LMWH
-
Fondaparinux
-
IV DTIs
Frage 42
Frage
Which of the following is correct regarding warfarin?
Antworten
-
It causes less GI bleeding than dabigatran
-
It causes more GI bleed than Rivaroxaban
-
It causes less GI bleeds than Apixaban
-
It causes less ICH in Direct Factor X inhibitors and Dabigatran
Frage 43
Frage
How long should one hold warfarin before major surgery
Antworten
-
24 hours
-
48 hours
-
6 hours
-
5 days
Frage 44
Frage
Which of the following has no reversal agent or is irreversible?
Antworten
-
LMHW
-
UFH
-
Warfarin
-
Rivaroxaban
Frage 45
Frage
Which of the following is not a side effect of Acetazolamide?
Antworten
-
Metabolic acidosis
-
Kidney stones
-
Paresthesia
-
Hypernatremia
Frage 46
Frage
Which of the following is NOT a cause for concern of sodium nitroprusside-induce cyanide toxicity?
Frage 47
Frage
Which of the following is true about SELECTIVE beta blockers? Choose all that apply:
Antworten
-
Safe to use in COPD patients
-
Has a slightly better metabolic effect
-
Loses selectivity at lower doses
-
Has little effect in patients with reversible airway disease
Frage 48
Frage
Which of the following is a correct rationale as to why we would use a beta blocker to treat MI/angina peri-operatively? Choose all that apply:
Antworten
-
To decrease production of aqueous humor
-
To decrease HR
-
To decrease contractility
-
To decrease portal hypertension
-
To inhibit vasodilatation or arteriolar spasms over the cortex
-
To decrease oxygen demand
Frage 49
Frage
Which of the following is not a characteristic of fondaparinux?
Antworten
-
It directly affects factor X
-
It is renally excreted
-
It has a long half-life, so not good for bridging with warfarin
-
There is still risk of HIT
Frage 50
Frage
The benefit to using calcitriol over vitamin D analogs is that it can decrease the chance of hypercalcemia and hyperphosphetemia.
Frage 51
Frage
Which of the following are nonselective beta blockers? Choose all that apply:
Antworten
-
Atenolol
-
Carvedilol
-
Propranolol
-
Metoprolol
-
Nadolol
-
Timolol
-
Labetalol
-
Satelol
Frage 52
Frage
Which of the following diuretics is the most potent?
Frage 53
Frage
Which of the following is correct regarding warfarin reversal agents?
Antworten
-
PCC are more efficient than FFP
-
PCC is usually given in a large volume
-
FFP and PCC are given with Vitamin K
-
FFP has larger risk of thrombosis
Frage 54
Frage
Which of the following is a side effect of hydralazine ONLY?
Frage 55
Frage
Which of the following would you never want to give with nitrates due to their drug interaction?
Antworten
-
Prostanoids
-
ERAs
-
Hydralazine
-
PDE-5 drugs
Frage 56
Frage
Which of the following prostanoids can cause sepsis?
Antworten
-
Epoprostenol
-
Treprostinil (Remodulin)
-
Iloprost
-
Trerostinil (Tyvaso)
Frage 57
Frage
Which of the following prostanoids can cause severe hypotension?
Antworten
-
Epoprostenol
-
Treprostinil (Remodulin)
-
Treprostinil (Tyvaso)
-
Ilioprost
Frage 58
Frage
Treprostinil (Tyvaso) is an inhaled prostenoid
Frage 59
Frage
Which of the following are NOT safe to use during pregnancy? Choose all that apply:
Antworten
-
PDE-5 drugs
-
Sodium nitroprusside
-
ERAs
-
Prostenoids
-
Riociguat
Frage 60
Frage
Which of the following antiplatelets works by inhibiting ADP receptor?
Antworten
-
GP IIb/IIIA inhibitors
-
Vorapaxar
-
P2Y12 inhibitors
-
ASA
Frage 61
Frage
Why are endothelin receptor antagonists used as a cardiac drug?
Antworten
-
It's ability to block ETB receptor
-
Because of its vasoconstricting effects
-
Because of its ability to release NO to cause vasodilation
-
It's ability to block ETA receptor
Frage 62
Frage
Which of the following causes an increase in INR?
Frage 63
Frage
Nitrate tolerance can be fixed by having a nitrate-free period lasting from 4-8 hours
Frage 64
Frage
How do calcium-channel blockers cause decrease in contractility, SA node rate, and AV node conduction velocity?
Antworten
-
By blocking sodium influx, causing calcium overload through the sodium/calcium exchanger
-
Blocking calcium channels, blocking calcium influx, causing dilation in arterial smooth muscle leading to decrease in afterload
-
Blocking calcium channels, blocking calcium influx, causing dilation in venous smooth muscle leading to decrease in afterload
-
Blocking calcium channels, blocking calcium influx, causing dilation in venous smooth muscle leading to decrease in preload
Frage 65
Frage
When using dihydropyridines, one must be careful when using it with digoxin and beta blockers, as this may cause additive negative effects on cardiac conduction
Frage 66
Frage
Which of the following is correct regarding nitrates and their mechanism of action?
Antworten
-
They cause arterial dilation
-
They are denitrated to NO, increasing cGMP and causing increase in dilation
-
They are denitrated to NO, decreasing cGMP and causing increase in dilation
-
Releases NO from the drug itself, causing vasodilation
Frage 67
Frage
Which of the following is a reason for loss of response to ESA therapy?
Antworten
-
Hypertension
-
Benign process
-
Iron deficiency
-
Pure white cell aplasia
Frage 68
Frage
Which of the following adrenergic agonists can cause a decrease in renal blood flow as an adverse effect?
Antworten
-
Epinephrine and Norepinephrine
-
Dobutamine and Epinephrine
-
Norepinephrine and Dopamine
-
Phenylephrine and Dobutamine
Frage 69
Frage
Which of the following adrenergic agonists can cause reflex bradycardia?
Antworten
-
Dobutamine
-
Epinephrine
-
Phenylephrine
-
Dopamine
Frage 70
Frage
Which of the following is NOT a side effect of alpha-1 adrenergic blockers?
Antworten
-
Floppy Iris Syndrome
-
Prolonged QT interval
-
Bradycardia
-
Orthostatic hypertension
Frage 71
Frage
ARBs are not used as first line therapy despite the less occurrence of side effects.
Frage 72
Frage
Which of the following is not a side effect of potassium-sparing diuretics?
Antworten
-
GI symptoms
-
Ototoxicity
-
Metabolic acidosis
-
Hyperkalemia
Frage 73
Frage
Which of the following IV iron products can alter magnetic resonance imaging studies?
Antworten
-
Iron dextran
-
Ferric gluconate
-
Ferumoxytol
-
Ferric carboxymaltose
Frage 74
Frage
Which of the following IV iron products can cause an anaphylactic reaction?
Antworten
-
Iron dextran
-
Ferric gluconate
-
Ferumoxytol
-
Ferric carboxymaltose
Frage 75
Frage
Iron sucrose is given in divided doses, about 10 dialysis sessions
Frage 76
Frage
Which of the following is not a side effect of loop diuretics?
Antworten
-
Hypomagnesemia
-
Hypocalcemia
-
Hypernatremia
-
Ototoxicity
Frage 77
Frage
Which of following phosphate binders can cause metabolic acidosis?
Antworten
-
Calcium carbonate
-
Calcium acetate
-
Renagel
-
Renvela
Frage 78
Frage
Aliskiren inhibits the conversion of angiotensin I to angiotensin II.
Frage 79
Frage
Ranolazine inhibits myocardial cell sodium/calcium exchanger, preventing ischemia-induced contractile dysfunction and delaying the onset of angina
Frage 80
Frage
Which of the following a Class I drug?
Antworten
-
Propafenone
-
Propranolol
-
Amiodarone
-
Diltiazem
Frage 81
Frage 82
Frage 83
Frage
Which is the best drug for use in patients with CHF or structural heart disease?
Antworten
-
Flecainide
-
Propafenone
-
Amiodarone
-
Verapamil
-
Dofetilide
Frage 84
Frage
Choose all that would be used for cardioversion of atrial fibrillation.
Antworten
-
Dofetilide
-
Ibutilide
-
Verapamil
-
Procainamide
-
Lidocaine
-
Digoxin
Frage 85
Frage
Which of the following is a side effects of Amiodarone?
Frage 86
Frage
Which of the following has beta-blocking activity?
Antworten
-
Propafenone
-
Flecainide
-
Ibutilide
-
Procainamide
Frage 87
Frage
Which of the following does NOT rely on renal function for elimination
Antworten
-
Sotalol
-
Dofetilide
-
Digoxin
-
Amiodarone
Frage 88
Frage
How does adenosine function in stress testing?
Antworten
-
Causes vasodilation in healthy arteries, revealing the diseased coronary arteries
-
Causes vasoconstriction in healthy arteries, revealing the diseased coronary arteries
-
Causes vasodilation in diseased arteries, revealing the healthy coronary arteries
-
Causes vasoconstriction in diseased arteries, revealing healthy coronary arteries
Frage 89
Frage
Which of the following is correct regarding digoxin?
Antworten
-
Inhibits potassium channels, decreasing intracellular potassium
-
Inhibits sodium-potassium ATPase, increasing sodium concentration thereby increasing calcium concentration
-
Causes negative inotropic effects
-
Causes positive dromotropic/chronotropic effects
Frage 90
Frage
Choose which of the following is true for Amiodarone
Antworten
-
Shorter half life than dronedarone
-
Slightly more effective than dronedarone in Afib patients
-
High risk of side effects
-
More GI side effects
-
I2 in structure and effects thyroid
-
Does not have negative inotropic effects
-
Cannot be used for CHF
Frage 91
Frage
How do calcium channel blockers work as antiarrhythmics?
Antworten
-
They dilate arterial smooth muscle
-
Mostly effects the sodium channels in atrial and ventricular tissues and Purkinjie fibers
-
Acts on the SA and AV node
-
Blocks sodium channels
Frage 92
Frage
Which of the following is correct regarding the use of beta blockers perioperatively?
Antworten
-
Should be continued in patients who are already on a beta blocker
-
Use of them perioperatively in any situation is standard of practice
-
Perioperative beta blockage started within one day or less before noncardiac surgery decreases risk of stroke, death, hypotension, and bradycardia
-
It is not a clinical contreversy
Frage 93
Frage
Which of the following drugs should you be cautious due to chance of developing QT prolongation?
Antworten
-
Dronedarone
-
Beta-blockers
-
Felcainide
-
Digoxin
Frage 94
Frage
Which of the following drug classes could cause Torsades de Pointes?
Antworten
-
Beta blockers
-
Class IA drugs
-
Class IB drugs
-
Calcium channel blockers
Frage 95
Frage
Which of the following drugs can be used for ventricular arrhythmias?
Antworten
-
Propafenone
-
Digoxin
-
Dofetilide
-
Ibutilide
Frage 96
Frage
Which of the following CANNOT be used for cardioversion?
Antworten
-
Dofetilide
-
Ibutilide
-
Propafenone
-
Verapamil