Pharm exam #3

Beschreibung

Made up questions for exam 3
Diana Flores
Quiz von Diana Flores, aktualisiert more than 1 year ago
Diana Flores
Erstellt von Diana Flores vor mehr als 9 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Which of the following is not safe during pregnancy?
Antworten
  • ACEI
  • ARB
  • Aliskiren
  • None are safe during pregnancy

Frage 2

Frage
Which of the following metabolic changes is not seen with use of loop diuretics?
Antworten
  • Decrease in Ca
  • Decrease in K
  • Increase in Mg
  • Increase in Glucose

Frage 3

Frage
Which of the following is not a side effect of thiazides?
Antworten
  • Hyponatremia
  • Metabolic alkalosis
  • Hypouricemia
  • Sexual dysfunction

Frage 4

Frage
Which of the following G IIb/IIIa receptor antagonists has a long half life and is irreversible?
Antworten
  • ASA
  • Tirofiban
  • Abciximab
  • Eptifibatide

Frage 5

Frage
Which of the following is not a side effect of osmostic diuretics?
Antworten
  • Electrolyte imbalance
  • Anuria
  • Local pain and venous irritation
  • Acute renal failure

Frage 6

Frage
Which of the following is a characteristic of LMWH?
Antworten
  • Low bioavailability
  • Monitored with PTT
  • Inexpensive
  • Renally excreted

Frage 7

Frage
Which of the following is not a side effect of Aliskiren?
Antworten
  • Decrease in uric acid
  • Diarrhea
  • Abdominal pain
  • Angioedema

Frage 8

Frage
Which of the following is not correct regarding eplerenone?
Antworten
  • It is more expensive than spironolactone
  • Less endocrine-related side effects than spironolactone
  • Lower chance of hyperkalemia
  • Higher affinity for aldosterone receptors

Frage 9

Frage
Which of the following is not a side effect of ACEI?
Antworten
  • Cough
  • Hypotension
  • Gynecomastia
  • Hyperkalemia

Frage 10

Frage
Acetazolamide causes metabolic alkalosis because you excrete bicarbonate, and therefore it is best to administer this diuretic to metabolic acidic patients.
Antworten
  • True
  • False

Frage 11

Frage
Which of the following are better to avoid with use of potassium-sparing diuretics?
Antworten
  • ACEI
  • Lithium
  • Eplerenone
  • Amiloride

Frage 12

Frage
Choose which of the following you would administer to a CKD patient
Antworten
  • Thiazide
  • CCB
  • ACEI
  • ARB

Frage 13

Frage
Which of the following diuretics act on the distal convoluted tubule to block sodium reabsorption?
Antworten
  • Aldosterone antagonists
  • Thiazides
  • Loop diuretics
  • CAIs

Frage 14

Frage
You always have drug interactions with NSAIDS with use of diurectics because they inhibit prostaglandins which antagonizes the action of diurectics
Antworten
  • True
  • False

Frage 15

Frage
Which diuretic would you not want to use in a patient who has gout?
Antworten
  • Loop diuretics
  • Sodium channel blockers
  • Aldosterone receptor antagonists
  • Thiazides

Frage 16

Frage
How does Conivaptan promote free water diuresis?
Antworten
  • By stimulating cGMP resulting in vascular smooth muscle relaxation
  • By being excreted unchanged and causing water to be retained within the proximal tubule and descending loop of Henle due to the freely permeable water
  • By blocking the epithelial sodium channels on principal cells and cause sodium excretion
  • By antagonizing vasopressing

Frage 17

Frage
Lisinopril antagonizes the AT1 receptor
Antworten
  • True
  • False

Frage 18

Frage
Which of the following metabolic changes would you see with the use of a thiazide?
Antworten
  • Increase Mg
  • Increase Ca
  • Decrease glucose
  • Increase in potassium

Frage 19

Frage
Hydrochlorthiazide is used more than chlorthalidone because it is more potent and research has shown that it produces a greater reduction in systolic blood pressure.
Antworten
  • True
  • False

Frage 20

Frage
In which of the following conditions would not benefit from the use of vasopressin receptor antagonists?
Antworten
  • Urinary frequency
  • CHF
  • cirrhosis
  • SIADH

Frage 21

Frage
Which of the following is a side effect Bosentan?
Antworten
  • Epistaxis
  • Visual disturbances
  • Liver cirrhosis
  • Dyspepsia

Frage 22

Frage
Which of the following would require careful dosing in a renal failure patient?
Antworten
  • Fondaparinux
  • Abciximab
  • Warfarin
  • Argatraban

Frage 23

Frage
Which of the following drug combinations would not be beneficial?
Antworten
  • Metolazone and Bumetanide
  • HCTZ and ARB
  • ACEI and ARBs
  • Furosemide and Lisinopril

Frage 24

Frage
Liver toxicity is a side effect of tolvaptan?
Antworten
  • True
  • False

Frage 25

Frage
Which of the following have short half-lives
Antworten
  • UFH
  • Warfarin
  • ASA
  • Fondaparinux
  • Vorapaxar
  • Abciximab
  • Eptifibatide
  • Tirofiban

Frage 26

Frage
Why do we need to overlap warfarin and heparin or LMWH in a patient with a new VTE?
Antworten
  • Because you want to deactivate antithrombin
  • It takes about 5 days to replace activated clotting factors with dysfunctional clotting factors
  • It takes about 5 days to replace Protein C and Protein S
  • You should never overlap warfarin with LMWH or UFH

Frage 27

Frage
Which of the following antiplatelets can cause dyspnea?
Antworten
  • Prasugrel
  • Ticagrelor
  • Clopidogrel
  • Ticlopidine

Frage 28

Frage
Which of the following prostanoids can cause epistaxis?
Antworten
  • Epoprosternol
  • Iloprost
  • Treprostinil (Remodulin)
  • Treprostinil (Tyvaso)

Frage 29

Frage
Which of the following is safe during lactation?
Antworten
  • Dabigatran
  • Direct X inhibitors
  • Warfarin
  • Indirect X inhibitors

Frage 30

Frage
Which of the following antiplatelets can be used when a patient has had a cardiac event while taking clopidogrel?
Antworten
  • Ticlopidine
  • Ticagrelor
  • Prasugrel
  • UFH

Frage 31

Frage
Which of the following antiplatelets is used with aspirin in post-ACS patients?
Antworten
  • Ticagrelor
  • Ticlopidine
  • Prasugrel
  • Clopidogrel

Frage 32

Frage
Liver toxicity is a side effect of conivaptan
Antworten
  • True
  • False

Frage 33

Frage
Which of the following antiplatelets is hardly used in clinical practice and can cause neutropenia?
Antworten
  • Ticagrelor
  • Clopidogrel
  • Prasugrel
  • Ticlopidine

Frage 34

Frage
Which of the following antiplatelets is contraindicated for patients with a history of stroke/TIA?
Antworten
  • Prasugrel
  • Ticagrelor
  • Clopidogrel
  • Ticlopidine

Frage 35

Frage
Ranolazine can be used ONLY in acute angina attacks
Antworten
  • True
  • False

Frage 36

Frage
It is important to hold indirect factor X inhibitors for at least 48 hours
Antworten
  • True
  • False

Frage 37

Frage
Why is it important to place a patient who develops HIT on another anticoagulant?
Antworten
  • To decrease the platelet count.
  • To prevent a prothrombotic condition
  • To prevent bleeding.
  • To induce a prothrombotic condition

Frage 38

Frage
Which of the following is not part of the treatment for HIT?
Antworten
  • Stop heparin products
  • Stop warfarin until platelet count is above 150,000
  • Use alternative anticoagulants
  • Give a high dose of warfarin when restarting

Frage 39

Frage
Which of the following drugs can cause serious cardiovascular and thromboemolic events if dose and hemoglobin range is not taken into account?
Antworten
  • Calcitriol
  • ERAs
  • ESAs
  • Dopamine

Frage 40

Frage
Which of the following is not a characteristic of argatraban?
Antworten
  • Monitored by PTT
  • Hepatic elimination
  • Decrease in INR
  • Can be used for treatment of HIT

Frage 41

Frage
Which of the following is absolutely not safe during pregnancy?
Antworten
  • Warfarin
  • Heparin/LMWH
  • Fondaparinux
  • IV DTIs

Frage 42

Frage
Which of the following is correct regarding warfarin?
Antworten
  • It causes less GI bleeding than dabigatran
  • It causes more GI bleed than Rivaroxaban
  • It causes less GI bleeds than Apixaban
  • It causes less ICH in Direct Factor X inhibitors and Dabigatran

Frage 43

Frage
How long should one hold warfarin before major surgery
Antworten
  • 24 hours
  • 48 hours
  • 6 hours
  • 5 days

Frage 44

Frage
Which of the following has no reversal agent or is irreversible?
Antworten
  • LMHW
  • UFH
  • Warfarin
  • Rivaroxaban

Frage 45

Frage
Which of the following is not a side effect of Acetazolamide?
Antworten
  • Metabolic acidosis
  • Kidney stones
  • Paresthesia
  • Hypernatremia

Frage 46

Frage
Which of the following is NOT a cause for concern of sodium nitroprusside-induce cyanide toxicity?
Antworten
  • Renal dysfunction
  • Increasing dose during therapy
  • Post-MI
  • Increasing duration of therapy

Frage 47

Frage
Which of the following is true about SELECTIVE beta blockers? Choose all that apply:
Antworten
  • Safe to use in COPD patients
  • Has a slightly better metabolic effect
  • Loses selectivity at lower doses
  • Has little effect in patients with reversible airway disease

Frage 48

Frage
Which of the following is a correct rationale as to why we would use a beta blocker to treat MI/angina peri-operatively? Choose all that apply:
Antworten
  • To decrease production of aqueous humor
  • To decrease HR
  • To decrease contractility
  • To decrease portal hypertension
  • To inhibit vasodilatation or arteriolar spasms over the cortex
  • To decrease oxygen demand

Frage 49

Frage
Which of the following is not a characteristic of fondaparinux?
Antworten
  • It directly affects factor X
  • It is renally excreted
  • It has a long half-life, so not good for bridging with warfarin
  • There is still risk of HIT

Frage 50

Frage
The benefit to using calcitriol over vitamin D analogs is that it can decrease the chance of hypercalcemia and hyperphosphetemia.
Antworten
  • True
  • False

Frage 51

Frage
Which of the following are nonselective beta blockers? Choose all that apply:
Antworten
  • Atenolol
  • Carvedilol
  • Propranolol
  • Metoprolol
  • Nadolol
  • Timolol
  • Labetalol
  • Satelol

Frage 52

Frage
Which of the following diuretics is the most potent?
Antworten
  • Thiazides
  • Potassium-sparing diuretics
  • Loop diuretics
  • Sodium channel blockers

Frage 53

Frage
Which of the following is correct regarding warfarin reversal agents?
Antworten
  • PCC are more efficient than FFP
  • PCC is usually given in a large volume
  • FFP and PCC are given with Vitamin K
  • FFP has larger risk of thrombosis

Frage 54

Frage
Which of the following is a side effect of hydralazine ONLY?
Antworten
  • Sodium and water retention
  • Hypertrichosis
  • Precipitation of angina
  • Induced MI

Frage 55

Frage
Which of the following would you never want to give with nitrates due to their drug interaction?
Antworten
  • Prostanoids
  • ERAs
  • Hydralazine
  • PDE-5 drugs

Frage 56

Frage
Which of the following prostanoids can cause sepsis?
Antworten
  • Epoprostenol
  • Treprostinil (Remodulin)
  • Iloprost
  • Trerostinil (Tyvaso)

Frage 57

Frage
Which of the following prostanoids can cause severe hypotension?
Antworten
  • Epoprostenol
  • Treprostinil (Remodulin)
  • Treprostinil (Tyvaso)
  • Ilioprost

Frage 58

Frage
Treprostinil (Tyvaso) is an inhaled prostenoid
Antworten
  • True
  • False

Frage 59

Frage
Which of the following are NOT safe to use during pregnancy? Choose all that apply:
Antworten
  • PDE-5 drugs
  • Sodium nitroprusside
  • ERAs
  • Prostenoids
  • Riociguat

Frage 60

Frage
Which of the following antiplatelets works by inhibiting ADP receptor?
Antworten
  • GP IIb/IIIA inhibitors
  • Vorapaxar
  • P2Y12 inhibitors
  • ASA

Frage 61

Frage
Why are endothelin receptor antagonists used as a cardiac drug?
Antworten
  • It's ability to block ETB receptor
  • Because of its vasoconstricting effects
  • Because of its ability to release NO to cause vasodilation
  • It's ability to block ETA receptor

Frage 62

Frage
Which of the following causes an increase in INR?
Antworten
  • Dabigatran
  • Hypothyroidism
  • Bactrim with use of warfarin
  • Short gut syndrome

Frage 63

Frage
Nitrate tolerance can be fixed by having a nitrate-free period lasting from 4-8 hours
Antworten
  • True
  • False

Frage 64

Frage
How do calcium-channel blockers cause decrease in contractility, SA node rate, and AV node conduction velocity?
Antworten
  • By blocking sodium influx, causing calcium overload through the sodium/calcium exchanger
  • Blocking calcium channels, blocking calcium influx, causing dilation in arterial smooth muscle leading to decrease in afterload
  • Blocking calcium channels, blocking calcium influx, causing dilation in venous smooth muscle leading to decrease in afterload
  • Blocking calcium channels, blocking calcium influx, causing dilation in venous smooth muscle leading to decrease in preload

Frage 65

Frage
When using dihydropyridines, one must be careful when using it with digoxin and beta blockers, as this may cause additive negative effects on cardiac conduction
Antworten
  • True
  • False

Frage 66

Frage
Which of the following is correct regarding nitrates and their mechanism of action?
Antworten
  • They cause arterial dilation
  • They are denitrated to NO, increasing cGMP and causing increase in dilation
  • They are denitrated to NO, decreasing cGMP and causing increase in dilation
  • Releases NO from the drug itself, causing vasodilation

Frage 67

Frage
Which of the following is a reason for loss of response to ESA therapy?
Antworten
  • Hypertension
  • Benign process
  • Iron deficiency
  • Pure white cell aplasia

Frage 68

Frage
Which of the following adrenergic agonists can cause a decrease in renal blood flow as an adverse effect?
Antworten
  • Epinephrine and Norepinephrine
  • Dobutamine and Epinephrine
  • Norepinephrine and Dopamine
  • Phenylephrine and Dobutamine

Frage 69

Frage
Which of the following adrenergic agonists can cause reflex bradycardia?
Antworten
  • Dobutamine
  • Epinephrine
  • Phenylephrine
  • Dopamine

Frage 70

Frage
Which of the following is NOT a side effect of alpha-1 adrenergic blockers?
Antworten
  • Floppy Iris Syndrome
  • Prolonged QT interval
  • Bradycardia
  • Orthostatic hypertension

Frage 71

Frage
ARBs are not used as first line therapy despite the less occurrence of side effects.
Antworten
  • True
  • False

Frage 72

Frage
Which of the following is not a side effect of potassium-sparing diuretics?
Antworten
  • GI symptoms
  • Ototoxicity
  • Metabolic acidosis
  • Hyperkalemia

Frage 73

Frage
Which of the following IV iron products can alter magnetic resonance imaging studies?
Antworten
  • Iron dextran
  • Ferric gluconate
  • Ferumoxytol
  • Ferric carboxymaltose

Frage 74

Frage
Which of the following IV iron products can cause an anaphylactic reaction?
Antworten
  • Iron dextran
  • Ferric gluconate
  • Ferumoxytol
  • Ferric carboxymaltose

Frage 75

Frage
Iron sucrose is given in divided doses, about 10 dialysis sessions
Antworten
  • True
  • False

Frage 76

Frage
Which of the following is not a side effect of loop diuretics?
Antworten
  • Hypomagnesemia
  • Hypocalcemia
  • Hypernatremia
  • Ototoxicity

Frage 77

Frage
Which of following phosphate binders can cause metabolic acidosis?
Antworten
  • Calcium carbonate
  • Calcium acetate
  • Renagel
  • Renvela

Frage 78

Frage
Aliskiren inhibits the conversion of angiotensin I to angiotensin II.
Antworten
  • True
  • False

Frage 79

Frage
Ranolazine inhibits myocardial cell sodium/calcium exchanger, preventing ischemia-induced contractile dysfunction and delaying the onset of angina
Antworten
  • True
  • False

Frage 80

Frage
Which of the following a Class I drug?
Antworten
  • Propafenone
  • Propranolol
  • Amiodarone
  • Diltiazem

Frage 81

Frage
Dronedarone is a
Antworten
  • beta-blocker
  • potassium channel blocker
  • sodium channel blocker
  • calcium channel blocker

Frage 82

Frage
Lidocaine is
Antworten
  • for atrial arrhythmias
  • the strongest among the sodium channel blockers
  • used as a local anesthetic
  • a class IC drug

Frage 83

Frage
Which is the best drug for use in patients with CHF or structural heart disease?
Antworten
  • Flecainide
  • Propafenone
  • Amiodarone
  • Verapamil
  • Dofetilide

Frage 84

Frage
Choose all that would be used for cardioversion of atrial fibrillation.
Antworten
  • Dofetilide
  • Ibutilide
  • Verapamil
  • Procainamide
  • Lidocaine
  • Digoxin

Frage 85

Frage
Which of the following is a side effects of Amiodarone?
Antworten
  • Pulmonary fibrosis
  • Increase in iodine
  • Photosensitivity
  • These are all side effects of Amiodarone

Frage 86

Frage
Which of the following has beta-blocking activity?
Antworten
  • Propafenone
  • Flecainide
  • Ibutilide
  • Procainamide

Frage 87

Frage
Which of the following does NOT rely on renal function for elimination
Antworten
  • Sotalol
  • Dofetilide
  • Digoxin
  • Amiodarone

Frage 88

Frage
How does adenosine function in stress testing?
Antworten
  • Causes vasodilation in healthy arteries, revealing the diseased coronary arteries
  • Causes vasoconstriction in healthy arteries, revealing the diseased coronary arteries
  • Causes vasodilation in diseased arteries, revealing the healthy coronary arteries
  • Causes vasoconstriction in diseased arteries, revealing healthy coronary arteries

Frage 89

Frage
Which of the following is correct regarding digoxin?
Antworten
  • Inhibits potassium channels, decreasing intracellular potassium
  • Inhibits sodium-potassium ATPase, increasing sodium concentration thereby increasing calcium concentration
  • Causes negative inotropic effects
  • Causes positive dromotropic/chronotropic effects

Frage 90

Frage
Choose which of the following is true for Amiodarone
Antworten
  • Shorter half life than dronedarone
  • Slightly more effective than dronedarone in Afib patients
  • High risk of side effects
  • More GI side effects
  • I2 in structure and effects thyroid
  • Does not have negative inotropic effects
  • Cannot be used for CHF

Frage 91

Frage
How do calcium channel blockers work as antiarrhythmics?
Antworten
  • They dilate arterial smooth muscle
  • Mostly effects the sodium channels in atrial and ventricular tissues and Purkinjie fibers
  • Acts on the SA and AV node
  • Blocks sodium channels

Frage 92

Frage
Which of the following is correct regarding the use of beta blockers perioperatively?
Antworten
  • Should be continued in patients who are already on a beta blocker
  • Use of them perioperatively in any situation is standard of practice
  • Perioperative beta blockage started within one day or less before noncardiac surgery decreases risk of stroke, death, hypotension, and bradycardia
  • It is not a clinical contreversy

Frage 93

Frage
Which of the following drugs should you be cautious due to chance of developing QT prolongation?
Antworten
  • Dronedarone
  • Beta-blockers
  • Felcainide
  • Digoxin

Frage 94

Frage
Which of the following drug classes could cause Torsades de Pointes?
Antworten
  • Beta blockers
  • Class IA drugs
  • Class IB drugs
  • Calcium channel blockers

Frage 95

Frage
Which of the following drugs can be used for ventricular arrhythmias?
Antworten
  • Propafenone
  • Digoxin
  • Dofetilide
  • Ibutilide

Frage 96

Frage
Which of the following CANNOT be used for cardioversion?
Antworten
  • Dofetilide
  • Ibutilide
  • Propafenone
  • Verapamil
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