2679692
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Quiz von Becca Shaw, aktualisiert more than 1 year ago
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Erstellt von Becca Shaw
vor mehr als 9 Jahre
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Frage 1
Frage
Drugs are evenly distributed around the body. True or false?
Antworten
- True
- False
Frage 2
Frage
Irreversible binding is mainly confined to what?
Antworten
-
Receptor binding sites
-
Ion channels
-
Enzyme inhibitors
-
Transport/carrier proteins
Frage 3
Frage
Irreversible binding uses what type of bonding?
Antworten
-
Covalent
-
Hydrogen
-
Ionic
-
Van der Waals
Frage 4
Frage
Which of the following are examples of natural binding sites?
Antworten
-
Receptor binding sites
-
Modulatory sites
-
Allosteric sites
-
Enzyme active sites
Frage 5
Frage
Modulatory or allosteric sites are a type of separate site to which drugs can bind. True or false?
Antworten
- True
- False
Frage 6
Frage
Drugs that block function are known as
Antworten
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Antagonists at receptors
-
Inhibitors at transporters/carriers
-
Blockers at ion channels
-
Inhibitors at enymes
Frage 7
Frage
What is the generic name for Adrenaline?
Antworten
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Fluoxetine
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Noradrenaline
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Epinephrine
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Tetracycline
Frage 8
Frage
What is the generic name for Aspirin?
Antworten
-
Mefanamic acid
-
Epinephrine
-
Diacetylmorphine
-
Acetylsalicylic acid
Frage 9
Frage
What is the generic name for Heroin?
Antworten
-
Fluoxetine
-
Diacetylmorphine
-
Epinephrine
-
Acetylsalicylic acid
Frage 10
Frage
What is the generic name for Prozac?
Antworten
-
Fluoxetine
-
Diacetylmorphine
-
Acetylsalicylic acid
-
Mefanamic acid
Frage 11
Frage
The use of an antagonist on a receptor results in
Antworten
-
Enzyme activition
-
Opening of ion channels
-
No effect produced
-
Blockage of endognous mediators
Frage 12
Frage
What direct mechanism would an agonist have on a receptor molecule?
Antworten
-
Enzyme activation or inhibition
-
Opening or closing of ion channels
-
Modulation of ion channels
-
DNA transcription
Frage 13
Frage
What transduction mechanisms may occur due to the activity of an agonist on a receptor molecule?
Antworten
-
Ion channel modulation
-
DNA transcription
-
Enzyme inhibition or activation
-
Opening or closing of ion channel
Frage 14
Frage
Proteins that bind to specific molecules, called ligands, to produce a response are known as receptors. True or false?
Antworten
- True
- False
Frage 15
Frage
When drugs act through receptors, these receptors will always have exogenous ligands. True or false?
Antworten
- True
- False
Frage 16
Frage
Examples of endogenous ligands are
Antworten
-
Hormones
-
Diacetylmorphine
-
Fluoxetine
-
Neurotransmitters
Frage 17
Frage
The endogenous ligand is always an agonist. True or false?
Antworten
- True
- False
Frage 18
Frage
In the absence of ligands, receptors have no other function. True or false?
Antworten
- True
- False
Frage 19
Frage
Where are most receptors found?
Antworten
-
Embedded in the plasma membrane
-
Circulating in the blood
-
Lining the epithelium of the gut
-
In the brain
Frage 20
Frage
Which of the following statements are true regarding antagonists?
Antworten
-
They bind loosely to receptors
-
The produce no effect themselves
-
They prevent agonists from binding
-
The block the response
Frage 21
Frage
Which of the following statements is false regarding Histamine?
Antworten
-
It is an endogenous agonist
-
Binds to receptors on stomach parietal cells
-
Is an exogenous agonist
-
Causes release of gastric acid
Frage 22
Frage
Which of the following blocks the parietal histamine receptors?
Antworten
-
Fluoxetine
-
Acetylcholine
-
Epinephrine
-
Ranitidine
Frage 23
Frage
Histamine receptor H1 mediates which effect on the gastrointestinal tract?
Antworten
-
Inflammation
-
Bile secretion
-
Smooth muscle contraction
-
Gastric acid secretion
Frage 24
Frage
Histamine receptor H2 mediates which effect on the gastrointestinal tract?
Antworten
-
Inflammation
-
Secretion of gastric acid
-
Bile secretion
-
Smooth muscle contraction
Frage 25
Frage
Which anatagonist acts upon Histamine receptor H2 to prevent secretion of gastric acid?
Antworten
-
Ranitidine
-
Epinephrine
-
Acetylsalicylic acid
-
Mepyramine
Frage 26
Frage
Which antagonist acts upon Histamine receptor H1 to prevent contraction of smooth muscle in parietal cells?
Antworten
-
Epinephrine
-
Ranitidine
-
Mepyramine
-
Fluoxetine
Frage 27
Frage
Different receptors for the same endogenous agonist are called subtypes. True or false?
Antworten
- True
- False
Frage 28
Frage
Which of the following are a type of receptor family?
Antworten
-
Ionotropic receptors (ligand-gated ion channels)
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Kinase-linked receptors
-
Nuclear receptor (cytoplasmic)
-
Metabotropic receptors (G-protein coupled receptors)
Frage 29
Frage
Which of the following statements are true concerning ionotropic receptors?
Antworten
-
Channel formed from 3-5 subunits
-
Pore domain of each subunit forms a hydrophobic channel
-
Ligands bind to an intracellular domain
-
Ions flow selectively through the membrane
Frage 30
Frage
The following is typical of the mechanism of receptors incorporating ion channels: 1. Agonist binds to receptor 2. Change in ion concentration in the cell 3. Depolarisation or hyperpolarisation occurs 4. Cellular effects (response)
Antworten
- True
- False
Frage 31
Frage
Nicotinic acetylcholine receptor is a part of the ionotrophic receptor family. True or false?
Antworten
- True
- False
Frage 32
Frage
Which of the following statements is false regarding Metabotropic receptors? (G-protein coupled receptors)
Antworten
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Consists of a single polypeptide
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7 transmembrane domains
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Domains consist of beta helices
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Ligand binds either to extracellular domain or within transmembrane domain
Frage 33
Frage
Muscarinic acetylcholine receptors are in the family of metabotropic receptors. True or false?
Antworten
- True
- False
Frage 34
Frage
Alpha and beta adrenoceptors are examples of the 2nd messenger effects of GCPRs. True or false?
Antworten
- True
- False
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