Protein synthesis on the ER

Folding doesn't start until...

All protein translation starts in the cytosol

All aa in a protein can interact simultaneously

C term on the protein exits the ribosome first

Local folding precedes the final formation of the complete tertiary structure

Classic experiment Roth and Lodish Year: [blank_start]1970[blank_end] Subject: [blank_start]Viral mRNA[blank_end] Strategy: Adding [blank_start]Microsomes[blank_end] to the translation system. They have protein fucosylation in the [blank_start]Lumen[blank_end]. Conclusion: [blank_start]Vesicles[blank_end] fuse with specific surfaces in the cell so that transportation arrive at the [blank_start]correct destination[blank_end]