Frage 1
Frage
Aldosterone stimulates the reabsorption of water in the nephron via which process?
Antworten
-
Synthesis of glucose channels
-
Increasing the flow of filtrate
-
Upregulation of epithelial sodium channels
-
Excretion of water
Frage 2
Frage
Which of the following produce antibodies
Antworten
-
Erythrocytes
-
T lymphocytes
-
B lymphocytes
-
Thrombocytes
Frage 3
Frage
which of the following provides the correct definition of cor pulmonale
Antworten
-
abnormal enlargement of the right side of the heart as a result of diesease of the lungs or the pulmonary blood vessels
-
abnormal enlaregemnt of the left side of the heart as a resukt of disease of the lungs or the pulmonary blood vessels
-
abnormal enlargement of the right side of the heart as a resukt of an increase in systemic afterload
-
abnormal enlargement of the left side of the heart as a result of an increase in right sided afterload
Frage 4
Frage
During myocyte depolarisation this outside of the cell become:
Antworten
-
positive
-
negative
-
stays the same
-
become hyperpolerized
Frage 5
Frage
What is the source of energy used to power the sodium-potassium pump?
Frage 6
Frage
which of the following is true?
Antworten
-
In systolic heart failure the heart’s ejection fraction increases
-
In systolic heart failure the heart’s ejection fraction stays the same
-
In systolic heart failure the heart’s ejection fraction decreases
-
In diastolic heart failure the ejection fraction increases
Frage 7
Frage
During myocardial diastole the sodium / potassium pump:
Antworten
-
Pumps out 3 sodium ion and pump in 2 potassium ions
-
Pumps out 6 sodium ions and pumps in 4 potassium ions
-
Pumps in 3 sodium ions and pumps out 2 potassium ions
-
Pumps in 6 sodium ions and pumps out 4 potassium ions
Frage 8
Frage
Which of the following types of emphysema is most commonly associated with smoking and chronic bronchitis
Antworten
-
Paraseptal
-
Panacinar
-
Centriacinar
-
Irregular
Frage 9
Antworten
-
is composed of four identical subunits
-
has iron at the centre of haem groups which must be in the ferrous form to bind O2
-
binding of oxygen is reduced in the presence of high Pco2 because CO2 and O2 compete for the same binding sites on haemoglobin
-
variants (such as fetal haemoglobin) often differ from normal adult haemoglobin in the precise structure of the haem group.
Frage 10
Frage
Which of the following is a neurotransmitter in the sympathetic nervous system?
Antworten
-
Acetylcholine
-
Norepinephrine
-
Vasopressin
-
Enoximone
Frage 11
Frage
The alveolar pores that enable collateral ventilation are called:
Antworten
-
Pores of Oddi
-
Pores of Kohn
-
Pores of Dalton
-
Pores of Boyles
Frage 12
Frage
Peripheral chemoreceptors are highly responsive to:
Antworten
-
Dysponea
-
Coughing
-
Hypoxemia
-
Breath holding
Frage 13
Frage
Aspirin is given in the treatment of myocardial infarction in order to prevent platelet aggregation. Which of the following effects means it is useful in this situation?
Frage 14
Frage
During myocyte (heart cell) depolarisation, the inside of the cell becomes momentarily:
Antworten
-
positive
-
negative
-
electrically neutral
-
unchanged
Frage 15
Frage
The Law stating that the more the ventricle is filled with blood during diastole (end-diastolic volume), the greater the volume of ejected blood will be during the resulting systolic contraction (stroke volume) is the:
Antworten
-
Frank-Starling’s Law
-
Cushing’s Law
-
Virchow’s triad Law
-
Best-Banting Law
Frage 16
Frage
The anaerobic metabolism of carbohydrates results in the production of:
Antworten
-
Citric acids
-
keto acids
-
lactic acid
-
hydrochloric acid
Frage 17
Frage
Flattened T waves on an ECG can signify:
Antworten
-
1st Degree heart block
-
Hyperkaleamia
-
Hypokaleamia
-
Atrial fibrillation
Frage 18
Frage
The diuretic Spironolactone interferes with the action of which endogenous hormone?
Frage 19
Frage
During acidosis the pH scale moves
Antworten
-
up
-
down
-
stays the same
-
moves to one
Frage 20
Frage
A disease caused by the demyelination of the oligodendrocytes
Frage 21
Frage
Intra-plural pressure is:
Frage 22
Frage
Concerning fats, when triglyceride molecules contain only single carbon bonds (c-c-c) these are referred to as:
Antworten
-
Poly unsaturated fats
-
saturated fats
-
Hyper-carbonated fats
-
Mono unsaturated
Frage 23
Frage
With a nasal cannula in-situ @ 2L O2 what % increase in FiO2 will there be
Frage 24
Frage
Which of the following is a restrictive lung disease:
Antworten
-
Asthma
-
Pneumoconiosis
-
Emphysema
-
Chronic bronchitis
Frage 25
Frage
Heart failure results in which of the following type of hypoxia
Antworten
-
Anaemic hypoxia
-
Histo-toxic
-
Hypoxic
-
Stagnant
Frage 26
Frage
Type II pneumocytes in the lung are the major source of
Antworten
-
IgG
-
cytokines
-
oxygen
-
surfactant proteins (SP)
Frage 27
Frage
A reduction in lung compliance would lead to a
Frage 28
Frage
Which lung volume would (usually) be reduced in restrictive lung disease
Antworten
-
Inspiratory reserve volume
-
Function residual capacity
-
Residual volume reserve
-
Expiratory reserve volume
Frage 29
Frage
If the fraction of an inspired gas was .35 what would its partial pressure be at 1ATM
Antworten
-
210mmHg
-
160mmHg
-
350mmHg
-
266mmHg
Frage 30
Frage
E = P + pgh + ½ PV2 which, if we remove gravity, reads as E = P + ½ PV2. Or, more simply, the faster the flow, the lower the pressure is which theorem
Antworten
-
Venturi’s
-
Dalton’s
-
Bernoulli’s
-
Charles’s
Frage 31
Frage
Hypocalcaemia caused by hyperventilation results in which of the following signs
Antworten
-
Dahl’s sign
-
Palmar erythema
-
Trousseau sign
-
Schamroth's sign
Frage 32
Frage
Replacing inspired air with a gas mixture that contains 60% oxygen
Antworten
-
causes a large increase in oxygen content with little increase in oxygen saturation in a healthy person at high altitude
-
causes a large increase in arterial PaO2 and a small increase in oxygen content in a healthy person at sea level
-
would greatly enhance the exercise tolerance of a patient COPD
-
would greatly reduce the oxygen delivery problems of a patient in circulatory shock
Frage 33
Frage
Antidiuretic hormone (ADH) is secreted by
Antworten
-
Adrenal glands
-
Kidneys
-
Pineal gland
-
Hypothalamus
Frage 34
Frage
Macula densa cells help regulate blood pressure by detecting changes to
Antworten
-
Sodium
-
Potassium
-
oxygen
-
calcium
Frage 35
Frage
Which of the following anatomical portion of a nephron connects the Bowman’s capsule to the loop of Henle?
Frage 36
Frage
The gene responsible for causing Duchenne muscular dystrophy is found on
Frage 37
Frage
Which of the following is the primary neurotransmitter of the parasympathetic nervous system
Antworten
-
Adrenaline
-
Acetylcholine
-
Dopamine
-
Serotonin
Frage 38
Frage
Which of the following heart layers secretes pericardial fluid?
Antworten
-
Myocardium
-
Endocardium
-
Serous pericardium
-
Fibbrous pericardium
Frage 39
Frage
The Haldane effect states that
Antworten
-
for any given Pco2 less CO2 is carried by oxygenated blood
-
an increase in Pco2 shifts the O2 dissociation curve to the left
-
an increase in Pco2 reduces the amount of haemoglobin in the red cell.
-
for any given Pco2 more CO2 is carried by oxygenated blood
Frage 40
Frage
Ventilation is NOT increased by
Frage 41
Frage
The amount of a gas dissolved in a solution as a result of partial pressure is which of the following gas laws
Antworten
-
dalton
-
henrys
-
charles
-
boyles
Frage 42
Frage
How is the ejection fraction worked-out
Antworten
-
SV/EDV x 100
-
EDVEDV/SV x 100
-
RVEDV x EDV x 100
-
EDV/100 x 60
Frage 43
Frage
The layer of blood close to the walls of lung capillaries is known as the
Antworten
-
RBC layer
-
Tissue barrier layer
-
Alveolar fluid layer
-
plasma layer
Frage 44
Frage
A pulmonary embolism would result in
Frage 45
Frage
The rate of diffusion of a gas across a membrane is inversely proportional to the square root of its molecular weight - is a definition of which of the following gas laws
Antworten
-
ficks law
-
daltons law
-
grahams law
-
chales law
Frage 46
Frage
Angiotensin I is converted to angiotensin II in the:
Antworten
-
lungs
-
nephron
-
pancreas
-
bowman's capsule
Frage 47
Frage
Hydrostatic pressure at the venule end of a capillary is usually (approximately)
Antworten
-
25mmHg (3.3kPa)
-
32mmHhg (4.2kPa)
-
80mmHg (10.6kPa)
-
12mmhg (1.6Pa)
Frage 48
Frage
A symptom seen in the patient with Keto-acidosis
Antworten
-
Bradycardia
-
Keto-alkalosis
-
kussmaul respiration
-
Bradyapnoea
Frage 49
Frage
During DKA sodium bicarbonate levels are:
Antworten
-
raised
-
lowered
-
absent
-
normal
Frage 50
Frage
Which of the following will increase the stroke volume:
Antworten
-
Decreased venous return
-
Increased afterload
-
Decreased preload
-
Increased venous return
Frage 51
Frage
The renal system does not play a direct role in regulating which of the following
Frage 52
Frage
Angiotensin II exerts its action by binding to various receptors throughout the body. In response to angiotensin II, the adrenal cortex is stimulated to release
Antworten
-
Adrenaline
-
Angiotensin I
-
Angiotensin ll
-
Aldosterone
Frage 53
Frage
Most of the glucose that is filtered through the glomerulus undergoes reabsorption in the
Frage 54
Frage
Which is not a function of angiotensin ll
Frage 55
Frage
Which is not a sign of renal cell carcinoma
Antworten
-
Flank pain
-
Flank mass
-
Heamaturia
-
Cullen's sign
Frage 56
Frage
Aldosterone stimulates the reabsorption of water in the nephron via which process
Antworten
-
Synthesis of glucose channels
-
Increasing the flow of filtrate
-
Excretion of water
-
Upregulation of epithelial sodium channels
Frage 57
Frage
The majority of carbon dioxide produced by the body is transported
Frage 58
Frage
Von Hippel-Lindau syndrome is
Frage 59
Frage
4)The first stage of the RAAS is the release of angiotensinogen, which is produced (primarily)
Antworten
-
Carotid arch
-
Brain
-
Lungs
-
Liver
Frage 60
Frage
Insufficiency of ADH is a condition called
Antworten
-
Addison's disease
-
Renal disease
-
Cushing's disease
-
Diabetes insipidus
Frage 61
Frage
Antidiuretic hormone (ADH) is secreted by
Antworten
-
Kidneys
-
Adrenal glands
-
Hypothalamus
-
Pineal gland
Frage 62
Frage
In the adult the majority
Antworten
-
Basophils
-
Eosinophils
-
Lymphocytes
-
Neutrophils
Frage 63
Frage
Macula densa cells are chemoreceptors found in the
Antworten
-
Distal tubule
-
Proximal tubule
-
Descending loop of Henle
-
Ascending loop of Henle
Frage 64
Frage
The amount of air that is moved in and out of the lungs during normal quiet breathing is
Frage 65
Frage
increase in the partial pressure of carbon dioxide favours oxygen dissociation from
oxyHb. The effect is known as
Antworten
-
The Nernst effect
-
The Bohr effect
-
Henderson effect
-
Dalton effect
Frage 66
Frage
The Hering-Breuer reflex
Antworten
-
Inhibits expiration
-
prolongs inspiration time
-
Shortens inspiration time
-
Is initiated by expiration
Frage 67
Frage
Which definition best suits the term 'inflammation' in relation to asthma
Antworten
-
Inflammation is caused by infectious agents in asthma, and is mediated by antiproteases
-
Inflammation is associated with airway remodelling in asthma. Inflammation is triggered by a stimulus, and causes epithelial injury, among other things
-
Mast cells can help to reduce inflammation by releasing histamine and preventing further lung damage
-
Inflammation is caused by airway remodelling in asthma.
Frage 68
Frage
Interstitial fluid enters capillaries at the venular end through the action of
Antworten
-
Negative pressure
-
Colloid osmotic pressure
-
Active transport
-
Capillary co-transport
Frage 69
Frage
What are the classic signs of a cardiac tamponade
Antworten
-
Tachycardia, dyspnoea, fever
-
Bradycardia, arm weakness, diaphoresis
-
Hypertension, palpitations, chest pain
-
Hypotension, increased jugular venous distention, muffled heart sounds
Frage 70
Frage
The term 'ectopic pacemaker' (or ectopic focus)
Antworten
-
An ectopic arrythmia due to hyponatraemia
-
Any cardiac dysrhythmia
-
A shift of the pacemaker function of the SA node to another part of the heart
-
An arrythmia due to hyper
Frage 71
Frage
In cor pulmonale the
Antworten
-
the mean pulmonary arterial pressure increases
-
the mean arterial pressure decreases
-
the mean pulmo
-
the mean pulmonary arterial pressure is 10mmhg
Frage 72
Frage
a person who smoked 20 cigarettes a day for 30 years has a pack years of
Frage 73
Frage
which of the following types of emphysema is most commonly asscoiated with smoking and chronic bronchitis
Antworten
-
paraseptal
-
panacinar
-
centaicinar
-
irregular
Frage 74
Frage
a patients blood gas analysis shows that both their Paco2 and bicarbnate concentration are increased above normal by 25% what does this mean ?
Antworten
-
They are excercising and so producing more CO2
-
The arterial Ph is unchanged
-
They are likely to have renal damage
-
They are likely to be polycythaemic
Frage 75
Frage
Which of the following is not normally associated with chironic bronchitis
Frage 76
Frage
Urine is formed in a three step process, which of the follwoing gives the correct order in which these steps take place in the nephron
Antworten
-
Tubular secretion, tubular re-absorption, glomerular filtration
-
Tubular reabsorption, tubular secretion, glomerular filtration
-
Glomerular filtration, tubular reabsorption, tubular secretion
-
glomerular filtration, tubular secretion, tubular reabsorption
Frage 77
Frage
Which of the following is least likely to be present in the gfiltrate, (the filtrate produced by the nephron before it enters the loop of henle) of a healthy adult nnephron
Frage 78
Frage
Which of the following is not a function of aldosterone
Antworten
-
Stimulates the secretion of K+ into the tubular lumen
-
Stimulates Na+ and water reabsorption
-
Upregulates epithelial sodium channels
-
Causes vasodilation
Frage 79
Frage
Which of the following produces surfactant
Antworten
-
Type 1 pneumocytes
-
Type 2 pneumocytes
-
Oligodendrocytes
-
Schwann cells
Frage 80
Frage
Which of the following is NOT a restrictive lung disease
Antworten
-
pneumoconiosis
-
Silcosis
-
Tuberculosis
-
Asthma
Frage 81
Frage
The enzyme that assists rapid inter conversion of carbon dioxide and water into carbonic acid is
Antworten
-
Amylase
-
Lipase
-
Trypsin
-
Carbonic anhydrase
Frage 82
Frage
The (normal) intra-venous partial pressure of carbon dioxide is
Antworten
-
40 mmHg
-
55mmHg
-
46mmHg
-
35mmHg
Frage 83
Frage
Which of the following is NOT found in the service side of type 1 pneumocytes
Antworten
-
nerve endings
-
macrophages
-
Collagen
-
Surfactant
Frage 84
Frage
Within the cerebral spinal space and the CSF what regulates ventilation
Antworten
-
carbon dioxide
-
carbonic anhydrase
-
Hydrogen ions
-
carbonic acid
Frage 85
Frage
Carbon dioxide is how many times more soluble than oxygen
Antworten
-
10 times
-
20 times
-
100 times
-
40 times
Frage 86
Frage
With a nasal cannula, we assume that the fraction of O2 that is inspired (above the normal atmospheric level) increases by how much for every additional litre of oxygen flow administered
Antworten
-
10 percentage points
-
100 percentage points
-
4 percentage points
-
21 percentage points
Frage 87
Frage
Which of the following does NOT contribute to maintaining osmotic pressure
Antworten
-
Sodium
-
Glucose
-
Albumin
-
Calcium
Frage 88
Frage
A respiratory acidosis moves the O2 curve and the PH respectfully
Antworten
-
Right/down
-
Left/up
-
Right/up
-
left/down
Frage 89
Frage
the protein whose production gets affected in Duchenne muscukar dystrophy is
Antworten
-
actin
-
myotropin
-
dystropin
-
leucovorin
Frage 90
Frage
Duchenne muscular dystrophy can be cured with
Frage 91
Frage
The involvement of this muscle affects the breathing in duchenne muscular dystrophy
Antworten
-
triceps
-
biceps
-
diaphragm
-
quadriceps
Frage 92
Frage
Which of the following represents one of the most recent developments in the treatment of MD
Frage 93
Frage
SLUDGE syndrome stands for which of the following
Antworten
-
Salvation, lacrimation, urination, defacation, gastrointestinal symptoms and emesis
-
sodium retention, lactic acidosis, urine retention, deafness, gastrointestinal bleeding and episodes of dizzines
-
Scoliosis, limited movement, urinary failure, decay, gastrointestinal ulceration, and epilepsy
-
sepsis, lymphedema, ulceration, diabetes, genital warts and Ecoli infection
Frage 94
Frage
Which portion of the heart is the base and which sis the apex
Antworten
-
Two thirds apex and one third base
-
one third base, two thirds apex
-
one half base, one half apex
-
three quaters base and one quater apex
Frage 95
Frage
Which of the following factors increase cardiac output
Frage 96
Frage
Where is the stethoscope (best) placed to auscultate the mitral valve
Antworten
-
5th intercostal space at sternum
-
5th intercostal space inferior to left nipple
-
2nd intercostal space left of sternum
-
2nd intercostal space right of sternum
Frage 97
Frage
On the ECG the short flat segment between the S and T waves represents the refractory state of the
Antworten
-
Atrial myocardium
-
AV node
-
SA node
-
Ventricular myocardium
Frage 98
Frage
Considering cardiac tamponade - the heart is covered by
Antworten
-
pericardium
-
endocardium
-
epicardium
-
supracradium
Frage 99
Frage
Which of the following is isotonic
Antworten
-
0.9% saline
-
water
-
5% dextrose
-
Lucozade
Frage 100
Frage
Fenestrated capillaries are found in the
Antworten
-
muscles
-
adipose tissue
-
central nervous system
-
intestines
Frage 101
Frage
Which of the following would be the best initial management of an acute cardiac tamponade
Frage 102
Frage
which of the following is not a structure of the respiratory system
Antworten
-
pharynx
-
larynx
-
bronchus
-
hyoid
Frage 103
Frage
the roof of the nasal cavity is formed primarily by the
Antworten
-
cribriform plate
-
hard palate
-
superior concha
-
sphenoid
Frage 104
Frage
in the blood most of the carbon doixide is transported as
Antworten
-
carboxyhaemoglobin
-
dissolved carbon dioxide
-
as free hydrogen
-
as bicarbonate
Frage 105
Frage
peripheral chemoreceptors are located in
Antworten
-
lung tissue
-
pons and medulla
-
aortic & carotid bodies
-
renal arch
Frage 106
Frage
Factors determining the extent to which oxygen will combine with haemoglobin include
Antworten
-
partial pressure oxygen
-
blood temperature
-
blood PH
-
all of the above
Frage 107
Frage
expectorate in uncomplicated asthma has a high level of
Antworten
-
neutrophils
-
eosinophils
-
red blood cells
-
IgD
Frage 108
Frage
Which of the following is not a classic clinical characteristic of asthma
Antworten
-
dyspnoea
-
wheeze
-
cough
-
Increased FEV1
Frage 109
Frage
In the adult the majority of leukocytes are
Antworten
-
basophils
-
eosinophils
-
lymphocytes
-
neutrophils