Drug molecules - properties and actions & functional groups

Beschreibung

Masters Degree Pharmacy (Case 1 - Introduction) Quiz am Drug molecules - properties and actions & functional groups, erstellt von Alyssa B am 02/01/2016.
Alyssa B
Quiz von Alyssa B, aktualisiert more than 1 year ago
Alyssa B
Erstellt von Alyssa B vor mehr als 8 Jahre
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2

Zusammenfassung der Ressource

Frage 1

Frage
What shape is a sp3 hybridised C?
Antworten
  • Tetrahedral
  • Trigonal planar
  • Linear

Frage 2

Frage
What shape is a sp2 hybridised C
Antworten
  • Tetrahedral
  • Trigonal planar
  • Linear

Frage 3

Frage
What shape is a sp hybridised C
Antworten
  • Tetrahedral
  • Trigonal planar
  • Linear

Frage 4

Frage
Alkanes are unsaturated hydrocarbons. True or false?
Antworten
  • True
  • False

Frage 5

Frage
Alkenes are [blank_start]more[blank_end] reactive than alkanes because the delocalised electrons make them susceptible to attack by electrophiles.
Antworten
  • more

Frage 6

Frage
Alkenes undergo [blank_start]electrophilic addition reactions[blank_end]
Antworten
  • electrophilic addition reactions

Frage 7

Frage
Alkynes are [blank_start]less[blank_end] reactive than alkenes.
Antworten
  • less

Frage 8

Frage
Alkynes undergo
Antworten
  • Substitution reactions
  • Electrophilic addition reactions but at a quicker rate than alkenes
  • Nucleophilic substitution reactions
  • Electrophilic addition reactions but at a slower rate than alkenes

Frage 9

Frage
Arenes are [blank_start]highly unsaturated[blank_end] and [blank_start]cyclic.[blank_end]
Antworten
  • highly unsaturated
  • cyclic.

Frage 10

Frage
Arenas do not behave like alkenes and alkynes because they [blank_start]do not decolourise bromine water.[blank_end]
Antworten
  • do not decolourise bromine water.

Frage 11

Frage
What type of molecule is benzene?
Antworten
  • Trigonal planar
  • Planar
  • Linear
  • Tetrahedral

Frage 12

Frage
Benzene is a colourless liquid.
Antworten
  • True
  • False

Frage 13

Frage
Boiling point of benzene?
Antworten
  • 90 degrees
  • 100 degrees
  • 70 degrees
  • 80 degrees

Frage 14

Frage
Melting point of benzene
Antworten
  • 5.5 degrees
  • 10 degrees
  • 3 degrees
  • 2.5 degrees
  • 1 degrees

Frage 15

Frage
Label this drug molecule
Antworten
  • Aspirin

Frage 16

Frage
Label this drug molecule
Antworten
  • Ibuprofen

Frage 17

Frage
Label this drug molecule
Antworten
  • Diazepam

Frage 18

Frage
The halogen atom on an alkylhalide atom is attached to what other atom?
Antworten
  • Trigonal sp2 carbon atom
  • Tetrahedral sp carbon atom
  • Trigonal sp3 carbon atom
  • Tetrahedral sp3 carbon atom
  • Trigonal sp carbon atom

Frage 19

Frage
The bond in alkylhalide are non-polar.
Antworten
  • True
  • False

Frage 20

Frage
[blank_start]Cl-, Br- and I-[blank_end] are good leaving groups in nucleophilic substitution reactions.
Antworten
  • Cl-, Br- and I-

Frage 21

Frage
Alkyl fluorides and fluorocarbons are relatively unstable.
Antworten
  • True
  • False

Frage 22

Frage
Although the halogen-alkane bond is polar, they do not have a [blank_start]corresponding electron deficient region.[blank_end]
Antworten
  • corresponding electron deficient region.

Frage 23

Frage
Although the halogen-alkane bond is polar, they do not [blank_start]interact strongly with water molecules.[blank_end]
Antworten
  • interact strongly with water molecules.

Frage 24

Frage
Although the halogen-alkane bond is polar, they are generally _____
Antworten
  • less lipophilic than corresponding non-halogenated molecules
  • more hydrophilic than corresponding non-halogenated molecules
  • more lipophilic than corresponding non-halogenated molecules
  • less hydrophilic than corresponding non-halogenated molecules

Frage 25

Frage
Tick all that is correct about halogens in drugs
Antworten
  • Generally make the drug more lipophilic than corresponding non-halogenated molecules
  • Generally make the drug less lipophilic than corresponding non-halogenated molecules
  • Halogenated drugs are less readily metabolised than non-halogenated forms
  • Halogenated drugs are more readily metabolised than non-halogenated forms

Frage 26

Frage
Label this drug molecule
Antworten
  • DDT

Frage 27

Frage
Tick all that is correct about DDT
Antworten
  • Persistent in the environment
  • Chemically unstable
  • Chemically stable
  • Highly resistant to metabolism
  • Not very resistant to metabolism

Frage 28

Frage
Short-chain alcohols are [blank_start]freely miscible with water.[blank_end]
Antworten
  • freely miscible with water.

Frage 29

Frage
The interaction between short-chain alcohols and water can be explained [blank_start]by hydrogen bonding.[blank_end]
Antworten
  • by hydrogen bonding.

Frage 30

Frage
A permanent dipole exists in alcohol because of ...
Antworten
  • Electronegativity of the hydrogen
  • Electronegativity of the oxygen
  • Electropositive oxygen
  • Electropositive hydrogen

Frage 31

Frage
R-OH dissociates to give [blank_start]R-O-[blank_end]
Antworten
  • R-O-

Frage 32

Frage
R-OH accepts a [blank_start]proton to give R-OH2+[blank_end]
Antworten
  • proton to give R-OH2+

Frage 33

Frage
Acidity of alcohols depends on the [blank_start]R-group[blank_end]
Antworten
  • R-group

Frage 34

Frage
pKa is the [blank_start]negative log[blank_end] of acid dissociation constant
Antworten
  • negative log

Frage 35

Frage
Acidity of molecule is increased if it has [blank_start]electron withdrawing group[blank_end] near the -OH group
Antworten
  • electron withdrawing group

Frage 36

Frage
Acidity of molecule is also dependent on if the rest of the molecule can [blank_start]stabilise the negative charge.[blank_end]
Antworten
  • stabilise the negative charge.

Frage 37

Frage
Phenols are [blank_start]stronger acids[blank_end] than alcohols.
Antworten
  • stronger acids

Frage 38

Frage
Phenoxide ions are [blank_start]resonance stabilised.[blank_end]
Antworten
  • resonance stabilised.

Frage 39

Frage
What does the -OH functional group do and in what condition?
Antworten
  • Release H+ in aqueous solution.

Frage 40

Frage
Relate the O- to the stability of the molecule
Antworten
  • Resonance stabilises the negative charge

Frage 41

Frage
Fluorine is strongly electronegative.
Antworten
  • True
  • False

Frage 42

Frage
The C-F bond in fluorine is polarised.
Antworten
  • True
  • False

Frage 43

Frage
In fluorine, the partially positive charge on the carbon [blank_start]stabilises[blank_end] the negative charge on the hydroxyl group.
Antworten
  • stabilises

Frage 44

Frage
Tick all that is correct about the reactivity of phenols.
Antworten
  • Readily oxidised
  • Not so readily oxidised
  • Products are colourless because of the conjugated bonds
  • Products are frequently coloured because of the conjugated bonds

Frage 45

Frage
Contribution of alcohols to the properties of drugs: tick all that is correct about hydrogen bonding
Antworten
  • Decreases the polarity of molecule
  • Increases the polarity of molecule
  • Adds to water solubility but generally not sufficient alone to ensure full water solubility
  • Ensures full water solubility
  • Involved in drug-target interactions as either a hydrogen bond donor or acceptor

Frage 46

Frage
Label this molecule
Antworten
  • Diethylether

Frage 47

Frage
Label this molecule
Antworten
  • Morphine

Frage 48

Frage
Tick all this correct about ethers
Antworten
  • Do not have hydrogen attached to the oxygen
  • Can be hydrogen bond donors
  • Can be hydrogen bond acceptors
  • Show full water solubility
  • Show partial water solubility
  • Solubility increases with chain length
  • Solubility decreases with chain length

Frage 49

Frage
Ethers can form [blank_start]peroxides in contact with air.[blank_end]
Antworten
  • peroxides in contact with air.

Frage 50

Frage
Ethers are generally non-reactive
Antworten
  • True
  • False
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