Frage 1
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What shape is a sp3 hybridised C?
Antworten
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Tetrahedral
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Trigonal planar
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Linear
Frage 2
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What shape is a sp2 hybridised C
Antworten
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Tetrahedral
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Trigonal planar
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Linear
Frage 3
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What shape is a sp hybridised C
Antworten
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Tetrahedral
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Trigonal planar
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Linear
Frage 4
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Alkanes are unsaturated hydrocarbons. True or false?
Frage 5
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Alkenes are [blank_start]more[blank_end] reactive than alkanes because the delocalised electrons make them susceptible to attack by electrophiles.
Frage 6
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Alkenes undergo [blank_start]electrophilic addition reactions[blank_end]
Frage 7
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Alkynes are [blank_start]less[blank_end] reactive than alkenes.
Frage 8
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Substitution reactions
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Electrophilic addition reactions but at a quicker rate than alkenes
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Nucleophilic substitution reactions
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Electrophilic addition reactions but at a slower rate than alkenes
Frage 9
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Arenes are [blank_start]highly unsaturated[blank_end] and [blank_start]cyclic.[blank_end]
Antworten
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highly unsaturated
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cyclic.
Frage 10
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Arenas do not behave like alkenes and alkynes because they [blank_start]do not decolourise bromine water.[blank_end]
Frage 11
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What type of molecule is benzene?
Antworten
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Trigonal planar
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Planar
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Linear
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Tetrahedral
Frage 12
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Benzene is a colourless liquid.
Frage 13
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Boiling point of benzene?
Antworten
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90 degrees
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100 degrees
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70 degrees
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80 degrees
Frage 14
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Melting point of benzene
Antworten
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5.5 degrees
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10 degrees
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3 degrees
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2.5 degrees
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1 degrees
Frage 15
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Label this drug molecule
Frage 16
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Label this drug molecule
Frage 17
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Label this drug molecule
Frage 18
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The halogen atom on an alkylhalide atom is attached to what other atom?
Frage 19
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The bond in alkylhalide are non-polar.
Frage 20
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[blank_start]Cl-, Br- and I-[blank_end] are good leaving groups in nucleophilic substitution reactions.
Frage 21
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Alkyl fluorides and fluorocarbons are relatively unstable.
Frage 22
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Although the halogen-alkane bond is polar, they do not have a [blank_start]corresponding electron deficient region.[blank_end]
Frage 23
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Although the halogen-alkane bond is polar, they do not [blank_start]interact strongly with water molecules.[blank_end]
Frage 24
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Although the halogen-alkane bond is polar, they are generally _____
Antworten
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less lipophilic than corresponding non-halogenated molecules
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more hydrophilic than corresponding non-halogenated molecules
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more lipophilic than corresponding non-halogenated molecules
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less hydrophilic than corresponding non-halogenated molecules
Frage 25
Frage
Tick all that is correct about halogens in drugs
Antworten
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Generally make the drug more lipophilic than corresponding non-halogenated molecules
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Generally make the drug less lipophilic than corresponding non-halogenated molecules
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Halogenated drugs are less readily metabolised than non-halogenated forms
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Halogenated drugs are more readily metabolised than non-halogenated forms
Frage 26
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Label this drug molecule
Frage 27
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Tick all that is correct about DDT
Antworten
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Persistent in the environment
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Chemically unstable
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Chemically stable
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Highly resistant to metabolism
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Not very resistant to metabolism
Frage 28
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Short-chain alcohols are [blank_start]freely miscible with water.[blank_end]
Frage 29
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The interaction between short-chain alcohols and water can be explained [blank_start]by hydrogen bonding.[blank_end]
Frage 30
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A permanent dipole exists in alcohol because of ...
Frage 31
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R-OH dissociates to give [blank_start]R-O-[blank_end]
Frage 32
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R-OH accepts a [blank_start]proton to give R-OH2+[blank_end]
Frage 33
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Acidity of alcohols depends on the [blank_start]R-group[blank_end]
Frage 34
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pKa is the [blank_start]negative log[blank_end] of acid dissociation constant
Frage 35
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Acidity of molecule is increased if it has [blank_start]electron withdrawing group[blank_end] near the -OH group
Frage 36
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Acidity of molecule is also dependent on if the rest of the molecule can [blank_start]stabilise the negative charge.[blank_end]
Frage 37
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Phenols are [blank_start]stronger acids[blank_end] than alcohols.
Frage 38
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Phenoxide ions are [blank_start]resonance stabilised.[blank_end]
Frage 39
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What does the -OH functional group do and in what condition?
Frage 40
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Relate the O- to the stability of the molecule
Frage 41
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Fluorine is strongly electronegative.
Frage 42
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The C-F bond in fluorine is polarised.
Frage 43
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In fluorine, the partially positive charge on the carbon [blank_start]stabilises[blank_end] the negative charge on the hydroxyl group.
Frage 44
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Tick all that is correct about the reactivity of phenols.
Frage 45
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Contribution of alcohols to the properties of drugs: tick all that is correct about hydrogen bonding
Antworten
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Decreases the polarity of molecule
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Increases the polarity of molecule
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Adds to water solubility but generally not sufficient alone to ensure full water solubility
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Ensures full water solubility
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Involved in drug-target interactions as either a hydrogen bond donor or acceptor
Frage 46
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Label this molecule
Frage 47
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Label this molecule
Frage 48
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Tick all this correct about ethers
Antworten
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Do not have hydrogen attached to the oxygen
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Can be hydrogen bond donors
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Can be hydrogen bond acceptors
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Show full water solubility
-
Show partial water solubility
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Solubility increases with chain length
-
Solubility decreases with chain length
Frage 49
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Ethers can form [blank_start]peroxides in contact with air.[blank_end]
Frage 50
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Ethers are generally non-reactive