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Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
Of known structures (60-80% of genes) how many are multidomain proteins?
Antworten
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40
-
50
-
60
-
30
Frage 2
Frage
Different combinations of domains are advantageous because they allow the organism to specialise
Antworten
- True
- False
Frage 3
Frage
How can we recognize domains?
Antworten
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DNA sequencing
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Amino acid sequencing
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Structure
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Topology (fold)
Frage 4
Frage
Why are DNA/amino acid sequencing of little use when investigating relationships between proteins?
Antworten
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As diversion occurs, sequence patterns are lost even as the fold remains the same
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They can detect short evolutionary relationships only
-
The techniques for reading the sequences are unreliable
-
Identical sequences can give different aa sequences/folds
Frage 5
Frage
When investigating using structure, how do we identify domains?
Antworten
-
Amino acid sequence
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Domains have the same fold
-
The interaction of the protein with other proteins
Frage 6
Frage
There is a limited number of folds in nature (10^3-4)
Antworten
- True
- False
Frage 7
Frage
Structural similarity occurs from what kind of evolution?
Antworten
-
Divergent
-
Convergent
Frage 8
Frage
Sequence is more highly conserved than protein structure
Antworten
- True
- False
Frage 9
Frage
Define convergent evolution
Antworten
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The independent evolution of similar features in different lineages
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The carrying of a feature from a common ancestor into two lines, which allows the reconvergence of the two lines into a single species again
-
The dependent evolution of similar features in two species that interact/co-operate closely
Frage 10
Frage
How does the CATH system establish taxonomy?
Antworten
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Cut proteins into domains and use computor analysis to group domains
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Uses structure based analysis
Frage 11
Frage
Which of the following classifications would be in the Class portion of the CATH system
Antworten
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Connectivity of fold
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Barrel
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Mostly alpha
Frage 12
Frage
Which of the following would be in the Architecture domain of the CATH system
Antworten
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Mostly beta
-
Both
-
Two layer sandwitch
-
Connectivity of fold
-
Barrel
Frage 13
Frage
Put the following in order of their use in the CATH system
A- Class
B- Sequence Superfamily
C- Homologous Superfamily
D-Architecture
E- Topology
Antworten
-
A-D-E-C-B
-
B-A-C-E-D
-
D-E-A-B-C
Frage 14
Frage
There are 3 classes, 32 architectures and 820 topologies in the CATH system
Antworten
- True
- False
Frage 15
Frage
The SCOP classifications, in descending order, are Class-Superfamily-Family-Fold-Species
Antworten
- True
- False
Frage 16
Frage
What is the specification after Superfamiy in the Pfam system?
Antworten
-
Fold
-
Architecture
-
Clade
Frage 17
Frage
All the systems agree in _% of cases
Antworten
-
30-40
-
40-50
-
50-60
-
60-70
Frage 18
Frage
To be homologous, two proteins must have two of which of the following in common?
Antworten
-
Structural Similarity
-
Sequence Similarity
-
Functional Simiarity
-
Species Similarity
-
Genus Similarity
Frage 19
Frage
What is the following describing- a protein contained in two different species with a similar function due to divergent evolution
Antworten
-
Orthologues
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Paralogues
Frage 20
Frage
What is the following describing- changes to a sequence following gene duplication leads to a variant copy with an additional (usually similar) function in the same species
Antworten
-
Orthologues
-
Paralogues
Frage 21
Frage
Give the two defining features of orthologues
Antworten
-
RMSD of >4
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High SI
-
Low SI
-
SI may be high or low
Frage 22
Frage
NAD is a co-enzyme found in all living cells that accepts and donates electrons
Antworten
- True
- False
Frage 23
Frage
NAD is made of three nucleotides and a phosphate group
Antworten
- True
- False
Frage 24
Frage
Which of the following binds NAD when present in a protein?
Antworten
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A Rossman Fold
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A Sherman Fold
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A Fieldman Fold
Frage 25
Frage
The Rossman Fold has it's 6 beta sheets arranged in what order?
Antworten
-
654123
-
123456
-
615243
Frage 26
Frage
In a Rossman fold, the crossover of the strands form the binding site
Antworten
- True
- False
Frage 27
Frage
In lactate dehydrogenase, which terminal domain contains the Rossman fold?
Antworten
-
C
-
N
Frage 28
Frage
What is the role of the C-terminal domain in dehydrogenases?
Antworten
-
Enzyme specificity
-
Enzyme regulation
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Enzyme catalytic activity
Frage 29
Frage
Lactate dehydrogenase catalyses lactate --> oxaloacetate
Antworten
- True
- False
Frage 30
Frage
Malate dehydrogenase is structually identical to LADH, so why do they have different substrates?
Antworten
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An SI of 17%
-
They operate in cells where only one or the other is avalible
-
Lactate and malate are structurally identical, but have different components
Frage 31
Frage
How can we tell two proteins are not homologues?
Antworten
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They have a different function
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They have a different S.I
-
They're found in different species
-
They're structurally different
Frage 32
Frage
What is the following descrbing- the existence of a shared ancestry between two structures (in this case proteins)
Antworten
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Homology
-
Divergent evolution
-
Convergent evolution
Frage 33
Frage
Alcohol dehydrogenase contains a Rossman fold
Antworten
- True
- False
Frage 34
Frage
ADH and LDH have an RMSD of 2.2 & an S.I of 17%- what relationship do they share?
Antworten
-
Orthologues
-
Paralogues
Frage 35
Frage
In the case of sequence diversity between proteins, surface residues change less than core/functional site residues
Antworten
- True
- False
Frage 36
Frage
Where do residue insertions usually occur?
Antworten
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In the functional site
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In loops connecting secondary structures
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In alpha helices
Frage 37
Frage
The functional diversity of a domain superfamily depends on the fold
Antworten
- True
- False
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