Linkage Analysis

Beschreibung

Year 2 Quiz am Linkage Analysis, erstellt von gina_evans0312 am 26/12/2013.
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Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312 vor fast 11 Jahre
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1

Zusammenfassung der Ressource

Frage 1

Frage
Metaphase is the most important stage for genetic mapping
Antworten
  • True
  • False

Frage 2

Frage
Recombination cannot be detected in...
Antworten
  • Homozygotes
  • Heterozygotes
  • Because both alleles are different
  • Because both alleles are identical

Frage 3

Frage
What indicates linkage?
Antworten
  • The no of recombinants
  • The no of homozygotes
  • The no of heterozygotes

Frage 4

Frage
A generation bred from parents AB & ab, has 1 recombinant out of 20- is linkage involved
Antworten
  • Yes
  • No

Frage 5

Frage
Recombinant detecting probes can be fooled if double recombination occurs
Antworten
  • True
  • False

Frage 6

Frage
Which of the following gametes tend to recombine more around the centromere?
Antworten
  • Spermatocytes
  • Oocytes

Frage 7

Frage
Oocytes tend to recombine
Antworten
  • Around the telomeres
  • Around the centromere
  • More than spermatocytes
  • Less than spermatocytes

Frage 8

Frage
Most recombination occurs at random
Antworten
  • True
  • False

Frage 9

Frage
What is 1q42.3 referring to?
Antworten
  • Short arm of chromosome 1
  • Long arm of chromosome 1
  • Locus position (from telomere to centromere)
  • Locus position (from centromere to telomere)

Frage 10

Frage
Meiosis is made informative or uninformative depending on whether you can track the diseased allele
Antworten
  • True
  • False

Frage 11

Frage
What must be known for effective meosic analysis?
Antworten
  • Grandparent -> Grandchild phenotype
  • Grandchild & all siblings phenotype
  • Parent & all siblings -> Grandchild phenotype

Frage 12

Frage
Is the following informative for linkage analysis?
Antworten
  • Yes- the child is a recombinant
  • No- the child is heterozygous
  • No- the father is homozygous

Frage 13

Frage
How would you classify this?
Antworten
  • Uninformative non-recombinant
  • Informative recombinant
  • Informative Non-recombinant

Frage 14

Frage
This is an informative recombinant
Antworten
  • True
  • False

Frage 15

Frage
What is true of Recombinant/Human Pedigree Analysis?
Antworten
  • The lower the recombination frequency, the more likely the hypothysis is to be correct
  • The higher the recombination frequency, the more likely the hypothysis is to be correct

Frage 16

Frage
A mother has a disease, and has the alleles M1 & M2- what are the two hypothesis for pedigree analysis?
Antworten
  • M1 is diseased M2 is healthy
  • M1 is healthy M2 is diseased
  • M1 & M2 are healthy
  • M1 & M2 are diseased

Frage 17

Frage
Give the two Recombination frequencies for that above image
Antworten
  • 0.16 & 0.83
  • 1.66 & 8.33
  • 16.66 & 83.33

Frage 18

Frage
A higher recombination frequency means alleles are closer together
Antworten
  • True
  • False

Frage 19

Frage
Define a Marker
Antworten
  • Any mendelian character that can be used to follow a disease through a pedigree
  • A fluorescent dye used to find particular alleles
  • A mutagen used to create findable mutations
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