Zusammenfassung der Ressource
Frage 1
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What does genetic mapping rely on?
Antworten
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Inheritence phenotypes
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Polymorphic Markers
Frage 2
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How is the tracing of inheritence phenotypes done?
Frage 3
Antworten
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1% recombination
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10% recombination
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1kB
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10kB
Frage 4
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How are physical maps made?
Frage 5
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Physical maps must be made of physically isolated parts of the genome
Frage 6
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A genetic marker acts as a reference point in a linkage study
Frage 7
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Genes are usually used as markers in non-human studies. Why can they not be used in humans?
Antworten
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Human genes are more unstable
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Human genes vary too much
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Human genes are more highly conserved
Frage 8
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What is the preferred form of marker in humans?
Antworten
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Polymorphic introns
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Polymorphic Exons
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SNP's
Frage 9
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More polymorphic DNA= less useful
Frage 10
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Homozygotes are more useful in genetic mapping than heterozygotes
Frage 11
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How must markers be placed along the chromosome?
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Evenly spaced
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As lightly as possibly
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As densely as possible
Frage 12
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The aim it to combine genetic and physical maps
Frage 13
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Once you have a marker with a high linkage to a disease/trait, how do you use the physical map?
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Find the marker and look for genes very close to it
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Find the suspect gene and look for markers very close to it
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Find the marker and look for genes as far away as possible
Frage 14
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Which of the following are evenly distributed?
Antworten
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SNP's
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Minisatellites
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Microsatellites
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RFLP's
Frage 15
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Microsatellites are highly polymorphic
Frage 16
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Which of the following are most useful as markers?
Antworten
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RFLP's
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Minisatellites
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Microsetellites
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SNP's
Frage 17
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There are two alleles (usually) for RFLP's
Frage 18
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How are minisatellites typed?
Antworten
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Southern Hybridisation
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Gel Electrophoresis
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PCR
Frage 19
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There are more than 10^10 SNP's in the human genome