Frage 1
Frage
What stimulates the secretion of the CA's?
Frage 2
Frage
Once the membrane has been depolarised, what voltage gated channels open?
Frage 3
Frage
The influx of ions into the cell signals secretion by exocytosis
Frage 4
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What is stored in Catecholamine vesicles, along with the CA?
Antworten
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ATP
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ADP
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Fromogranin
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Chromogranin
Frage 5
Frage
ATP is -ve at body pH, whilst CA's are +ve
Frage 6
Frage
Why are CA's stored with these other substances?
Antworten
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They keep the CA's out of solution
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They keep the CA's in solution
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Which helps prevent vesicle lysis due to osmotic pressure
Frage 7
Frage
ATP can also act as a neurotransmitter
Frage 8
Frage
When concentrations of CA in the synapse are low, Alpha2 Adrenergic receptors are activated,
Frage 9
Frage
B2 receptors _ adenylate cyclase, which _ the production of cAMP, which _ the influx of ions
Antworten
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Stimulates, increases, increases
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Stimulates, increases, decreases
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Inhibits, increases, increases
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Inhibits, decreases, decreases
Frage 10
Frage
A2 adrenergic receptors have the opposite effect of B2 adrenergic receptors
Frage 11
Frage
Re-uptake Method 1 is presynaptic, and mediated by what?
Antworten
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Active transport
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Diffusion
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A Na+/K+ pump
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Na+ channel
Frage 12
Frage
Uptake Method 2 is extraneuronal and is used to...
Antworten
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Destroy excess adrenaline
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Secrete adrenaline into the bloodstream
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Stimulate separate neurones
Frage 13
Frage
Monoamine oxidase is found in the RER and interacts with cytoplasmic neurotransmitter
Frage 14
Frage
What is the role of monoamine oxidase (3 steps)?
Antworten
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Converts the amine --> aldehyde
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Reduction of Aldehyde --> Acid
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Reduction of Aldehyde --> Alcohol
Frage 15
Frage
Which enzyme uses S-Adenosty Methionine to methylate Neurotransmitters?
Frage 16
Frage
What is the final produce of the Oxidative pathway of Monoamine Oxidase?
Frage 17
Frage
What is the final produce of the Reductive pathway of Monoamine Oxidase?
Frage 18
Frage
In peripheral tissue, the oxidative pathway predominates. In the brain, the reduction pathway predominates.