Zusammenfassung der Ressource
Frage 1
Frage
enantiomers are non identical mirror images with a plane of symettry
Frage 2
Frage
enantiomers are a pair of stereoisomers that are non identical mirror images of eachother
Frage 3
Frage
diastereoisomers are
Antworten
-
a pair of non identical stereoisomers that are not mirror images of eachother
-
a pair of non identical stereoisomers that are mirror images of eachother
-
a pair of identical mirror images with a plane of symettry
Frage 4
Frage
when describing chiral centres.. (select all that are true)
Antworten
-
R/S classifies a chiral centre by the groups around it
-
D/L classifies a chiral centre by comparison to a reference compound glyceraldehyde
-
d/l classifies a molecule by the direction it rotates polarised light d is clockwise
-
+/- is the same as R/S. R = + S = -
Frage 5
Frage
Biosynthesis (synthesis of molecules in a biological system) is often stereoselective
Frage 6
Frage
Chiral synthesis in the laboratory is often very [blank_start]difficult[blank_end]. It is even harder to scale up to industrial scale. Two approaches to obtaining pure chiral molecules are [blank_start]Chiral separation[blank_end] (use a physical method e.g chromatography to separate the desired stereoisomer from a mixture) and [blank_start]The Chiral Pool[blank_end] (use a starting material that already contains a chriral centre.)
Antworten
-
difficult
-
straightforward
-
fast
-
Chiral separation
-
chiral synthesis
-
HPLC/MS
-
The Chiral Pool
-
The chemical pool
-
chiral separation
-
chiral splitting
Frage 7
Frage
about 25% of drugs are administered as a racemate - an equal mixture of stereoisomers
Frage 8
Frage
some drugs are given as a single isomer which means a larger dose is required
Frage 9
Frage
which of the following is FALSE
Antworten
-
for a pair of stereoisomers the one with the greater activity is the eutomer
-
for a pair of stereoisomers the one with the lesser activity is the distomer
-
the ratio between the distomer and the eutomer is the disumic ratio
Frage 10
Frage
select which apply about the ADME of stereoisomers:
Antworten
-
during ABSORPTION by transmembrane proteins stereoisomers of chiral drugs can absorb differently
-
during ABSORPTION by passive diffusion stereoisomers of chiral drugs absorb differently
-
DISTRIBUTION leads to the stereoisomers having different effects because they bind to the plasma proteins
-
METABOLISM causes stereoisomers to be the broken down same as the same enzymes are used for both R and S forms of the drug
Frage 11
Frage
The development of a [blank_start]single[blank_end] isomer drug from a previously marketed [blank_start]racemate[blank_end] is known as the [blank_start]chiral switch[blank_end]
Antworten
-
single
-
R-
-
multi
-
racemate
-
eutomer
-
tablet
-
distomer
-
chiral switch
-
chiral pool
-
chiral centre
Frage 12
Frage
which are advantages of the chiral switch?