Aspirin

Beschreibung

Need to know for HPA exam
Em J
Karteikarten von Em J, aktualisiert more than 1 year ago
Em J
Erstellt von Em J vor mehr als 6 Jahre
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Trade names Aspro, Disprin, Solprin, Astrix
Chemical name Acetylsalicylic acid
Therapeutic class NSAID/antipyretic
Pharmaceutical class Salicylates
Indications Inflammatory conditions: osteoarthritis, rheumatoid arthritis Fever Mild - Mod pain Prophylaxis of transient ischaemic attacks and MI
Action Produces analgesia and reduces inflammation by inhibiting the production of prostaglandins Also decreases platelet aggregation
Therapeutic effects Analgesia, reduction of inflammation and fever, decrease in transient ischaemic attacks and MI
Pharmacokinetics (absorption) Well absorbed from the upper small intestine. Enteric (SR) absorption may be unreliable. Rectal absorption is slow & variable.
Pharmacokinetics (Distribution) Rapidly & widely distributed, crossing the placenta and entering the breast milk
Pharmacokinetics (metabolism & excretion) Extensively metabolised by the liver, inactive metabolites excreted by the kidneys
Pharmacokinetics (half-life) 2 -3 hours for low doses, 15 - 30 hours for high doses where the liver reaches saturation
Contraindications/precaution Hypersensitivity to aspirin or other salicylates Bleeding disorders or thrombocytopenia (low platelet count) History of GI bleeding or ulcer disease History of asthma
Adverse reactions or side effects ENT: tinnitus, GIT: bleeding, dyspepsia, N + V, epigastric distress, abdo pain. HEP: hepatotoxicity HAEM: anemia, hemolysis SKIN: rash, urticaria
Assessment Pain & fever Lab tests: monitor hepatic function if signs of hepatotoxicity occur or if long term therapy is undertaken
Education Advise patient to report: tinnitus, unusual bleeding or bruising, black tarry stools or fever > 3 days
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