Chapter 10: Altered Neuronal Transmission

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Vocab for pathophysiology exam
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chromatolysis the swelling of a neuron because of injury
atrophy decrease in size of a cell (neuron)
neuronophagia phagocytosis and inflammatory responses caused by dead neuron damaging neighboring cells
intraneuronal inclusions distinctive structures formed in the nucleus or cytoplasm
sulci fissures of the brain
gyri irregular convolutions on the surface of the brain
gray matter the tissue of the cerebral cortex, basal ganglia, hypothalamus, and thalamus; primarily composed of cell bodies
white matter other brain structures composed primarily of myelinated axons and dendrites
blood-brain barrier (BBB) This protects the brain from exposure to potentially hazardous substances by reduced permeability in the capillaries that supply the brain/ transports substances in a selective manner because of tight junctions in endothelial cells lining capillaries of the brain
astrogliosis in the CNS, astrocytes respond to local tissue injury through proliferation, forming a "glial scar"
microglial nodules Reactive changes seen in the microglia include extension of the nucleus. They are "rod cells" in this state; when joined together with astrocytes, microglia combine to form these:
paresthesia abnormal sensation such as burning, pricking, tickling, or tingling
quadriplegia paralysis of all four extremities
focal ischemia inadequate perfusion to neurologic tissue; confined to a specific brain region
global ischemia ischemic injury occurs when there is inadequate perfusion to neurologic tissue; includes larger areas of brain tissue
contralateral opposite
glutamate the main excitatory neurotransmitter in the body, active in the promotion of higher-order functions. The effects are exerted when it binds to its receptors, stimulating a cascade of signal transduction events
papilledema edema of the optic disc
dermatomes body regions to which spinal nerves transmit impulses
distal axonopathy axonal degeneration from necrosis in response to significant injury to cell body or axon to neuron, causing inflammatory response and phagocytosis of cellular debris/ the injury will affects cells in distal areas of the body such as the hands and feet
neuronopathy axonal degeneration occurs from damage to the cell body
mononeuropathy nerve trauma limited to a single are; related to neuronopathy; i.e. carpal tunnel syndrome
polyneuropathy peripheral nerve damage involving multiple axons; usually occurs secondary to disease processes such as MS, DM, nutrient deficiency, and toxic agents such as arsenic
spastic inability of muscles to relax
athetoid or dyskinetic inability to control muscle movement
ataxic inability to control balance and coordination
tonic a state of continuous muscle contraction
clonic rapid succession of alternating muscle contractions and relaxations
demyelination degeneration of myelin
pseudobulbar affect uncontrollable laughing or crying effect
nystagmus irregular eye movements
hyrdocephalus "hydro" meaning water and "cephalus" meaning head; condition of increased ventricular and subarachnoid accumulation of cerebrospinal fluid
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