Frage | Antworten |
Leuprolide | GnRH analog גורם לשחרור מתמשך של GnRH בשימוש להורדת רמות טסטוסטרון וDHT "start up flare" |
Finasteride | 5- Alpha reductase inhibitore Treatment of BPH הורדת רמות DHT בלבד |
Liraglunide | GLP-1 receptor agonist Gs mediated Insulin secretion |
Exenatide | GLP-1 receptor agonist Gs mediated Insulin secretion |
Aromatase inhibitors | Anastrozole, Letrozole, Exemestane For treatment of breast cancer |
NO containing Bisphosphonate | Aledronate, Risedronate, Zoledronic acid |
Aledronate mecchanisem | FPP synthease inhibitor- osteoclast bone resorption inhibitors |
Teriparotide | PTH analoge |
Denosumab | Anti RANKL- Pre-osteoclast maturation inhibitor |
Pioglitazone Rosiglitazone | Thiazolidinedions |
Thiazolidinedions- Mechanisem | Binds to PPAR-gamma nuclear transtription regulatore. מורידים התנגדות לאינסולין בעיקר בעזרת העלאת adiponectin |
Thiazolidinedions- side effects | Weight gain, edema, hepatotoxicity, HF, incrise risk of fructures |
Acrbose Miglitol | Alpha- glucosidase inhibitors |
Bromocriptine Cabergoline | Dopamine agonist |
Pegvisomant | GH hormone receptor antagonist |
Tesamorelin | GHRH analog- used to treat HIV- associated lopodystrophy |
Aspart, Glulisine, lispro | Insulin- short acting |
Detemir, Glargin | Insulin- long acting |
Chlorpropamide Tolbutamide | First generation Sulonylureas |
Glimepiride Glipizide Glyburide | Second generation Sulonylureas |
Sitagliptin Saxagliptin Linagliptin | DDP-4 inhibitors 2 DM |
Pramlintide | Amylin analog- reduce gastic emptying and glucagone secretion |
Canagliflozin | SGLT-2 inhibitor Block reabsorbtion of glucose in PCT |
Conivaptan Tolvaptan | ADH antagonist- SIADH, block action of ADH at V2 recetpors |
Desmopressin acetate | Central diabetis insipidos |
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