456513
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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| Question | Answer |
| Bioinformatics | Use of computer science to analyse data |
| Aim- Organise Data | So it can be accessed and added to by other researchers |
| Aims- Develop Tools and Resources | To assist in data analysis |
| Uses- Use Tools to Analyse Data | Use results in a biologically meaningful way |
| Database | Collection of information stored in a computer |
| Primary Database | Database of primary data i.e from experiments and curation |
| Nucleic Acids- Primary Database | Database of nucleic acid sequences |
| Nucleic Acid Primary Database- Europe | NCBI- 66 million entries and increasing rapidly (different ones for America/Japan) |
| HGNC | Human Genomic Naming Committee |
| Protein Sequencing | Database of amino acid sequences of proteins |
| Protein Sequencing - Primary Database | Uniprot- annotations by 3 schools of PhD students |
| Protein Sequence- Taxonomic Identifier | Number assigned to each species and its proteins - Humans is 9606 |
| Protein Structure | Database of the 3D structure of proteins (folds etc.) |
| Protein Structure- Primary Database | Protein Data Bank- sorted by method of attainment |
| Protein Structure- E.C Number | Enzyme Classification Number |
| Role of the PDB | To normalise data from different sources |
| Biographic Databases | Store Original Literature |
| Secondary Database | Database of classifications derived from primary analysis i.e. protein superfamilies |
| Secondary Database- TRANSFAC | Superfamilies classified by nuclear sequences |
| Secondary Database- PFAM | Superfamilies classified by amino acid sequences |
| Secondary Database- CATH | Superfamilies classified by protein families |
| Database Problems- Sequencing Errors | Base pairs incorrect/Contaminated DNA/Missing sequences |
| Database Problems- Names/Data Entry Errors | Multiple names for a single gene/ Same name for 2 genes (common between yeast and humans) |
| Database Problems- Experimental Data Errors | Hard to detect |
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