5129625
Description
Flashcards by Amaal Salhieh, updated more than 1 year ago
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Created by Amaal Salhieh
over 8 years ago
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| Question | Answer |
| Penicillin Mechanism of Action | Cell wall disruption |
| PCN Excretion | Renal |
| PCN Resistance Patterns | -Beta-lactamase -altered binding site -Reduced entry |
| PCN is DOC for.. | Syphilis Streptococci |
| Ampicillin is DOC for... | Enterococcus Listeria |
| PCN adverse reactions | Rash GI distress Seizures Bone marrow suppression |
| CEPH MoA | Cell wall disruption |
| CEPH Resistance Patterns | Beta-lactamase Altered binding site Reduced entry |
| Ceftriaxone is DOC for.. | Bacterial meningitis |
| Cefepime is DOC for... | Pseudomonas Aeruginosa |
| Ceftaroline is an option for... | MRSA |
| CEPH Adverse Reactions | similar to PCN (rash, GI distress, seizures, bone marrow suppression) Cross allergy with PCN |
| Carbapenems MoA | Cell wall disruption |
| CARBAP Excretion | Renal |
| CARBAP Resistance Patterns | Carbapenemase Altered binding site Reduced entry |
| CARBAP Adverse Reactions | similar to PCN (rash, bone marrow suppression, seizures, GI distress) _Cross allergy with PSN _Seizures _Superinfections |
| Monobactam is aka... | Aztreonam |
| Monobactam MoA | Cell wall disruption |
| Monobactam Excretion | Renal |
| Monobactam Resistance Pattern | Altered binding site Enzymatic degradation |
| Monobactam Adverse Rxns | Similar to PCN (GI distress, seizures, bone marrow suppression, rash) No cross allergy to PCN |
| Aminoglycosides MoA | Protein synthesis 30s |
| AMINOG excretion | Renal |
| AMINOG Resistance Pattern | Reduced entry Enzymatic degradation |
| AMINOG Adverse Rxns | Nephrotoxicity Ototoxicity Neuromuscular blockade |
| Tetracycline MoA | Protein synthesis 30s |
| Tetracycline Excretion | Mostly renal |
| Tetracycline Resistance Pattern | Reduced entry Active efflux |
| Tetracycline is DOC for... | Chlamydia Arthropod-borne diseases |
| Tetracycline Adverse Rxns | GI distress Rash Photosensitivity Depressed bone growth Discolored teeth |
| Chloramphenicol MoA | Protein Synthesis 50s |
| Chloramphenicol Excretion | Renal |
| Chlorampenicol Resistance Pattern | Reduced entry Enzymatic degradation |
| Chloramphenicol | Aplastic anemia "Gray Baby Syndrome" Optic Neuritis |
| Macrolides MoA | 50s |
| Macrolides Excretion | Biliary |
| Macrolides Resistance Pattern | Altered binding site Reduced entry |
| Macrolides is DOC for... | Legionella Mycoplasma Diphtheria Pertussis |
| Macrolides Adverse Rxn | GI distress rash gout exacerbation |
| Quinupristin-dalfopristin MoA | 50s |
| Quinupristin-dalfopristin Excretion | Biliary |
| Quinupristin-dalfopristin Adverse Rxns | drug interactions hyperbilirubinemia arthralgias/myalgias vein sclerosis |
| Linezolid MoA | fMet-tRNA |
| Linezolid Excretion | Mostly biliary |
| Linezolid is DOC for | VRE MRSA penumonia |
| Linezolid Adverse Rxns | MAO inhibitor, enhances adrenergic and serotonergic meds, GI distress, thrombocytopenia |
| Daptomycin MoA | disruption of cell membrane potential |
| Daptomycin Excretion | Mostly renal |
| Daptomycin Resistance Pattern | ? membrane potential dissipation |
| Daptomycin is DOC for.. | MRSA, VRE other Gram + organisms found in skin and soft tissue infxns |
| Daptomycin Adverse Rxns | Muscle pain and weakness elevated CPK levels |
| Trimethoprim-sulfamethoxazole MoA | Folate synthesis |
| Trimethoprim-sulfamethoxazole Excretion | Renal |
| Trimethoprim-sulfamethoxazole Resistance Pattern | Altered binding site Reduced entry |
| Trimethoprim-sulfamethoxazole is DOC for... | Pneumocystis carinii Stenotophomonas maltophilia Nocardia |
| TMP-SMC Adverse Rxns | rash, GI distress, hepatic dysfunction, renal dysfunction, bone marrow suppression |
| Quinolones MoA | DNA Synthesis |
| Quinolones Excretion | Renal Biliary |
| Quinolones | Altered binding site Active efflux |
| Quinolones Adverse Rxns | rash, GI distress, drug interactions, bound by metals and cations |
| Vancomycin MoA | Cell wall disruption |
| Vanco Excretion | Renal |
| Vanco Resistance Pattern | Altered binding site |
| Vanco is DOC for... | PRSP meningitis ? MR Staph |
| Vano Adverse Rxns | ototoxicity ? nephrotoxicity vein sclerosis rash/Redman Syndrome |
| Clindamycin MoA | 50s |
| Clinda Excretion | Biliary |
| Clinda Resistance Pattern | Altered binding site |
| Clinda Adverse Rxns | rash, GI distress Pseudomembranous colitis |
| Metronidazole MoA | DNA synthesis |
| Metro Excretion | Biliary |
| Metro is DOC for... | anaerobic bacteria |
| Metro Adverse Rxns | metallic taste, Disulfiram-like reaction, peripheral neuropathy, pancreatitis |
| What antibiotics are excreted by the biliary system? | Macrolides Quinopristin-dalfopristin Linezolid (mostly) Quinolones (and renal) Clindamycin Metronidazole |
| What antibiotics are excreted by the renal system? | Penicillin Cephalosporins (mostly) Carbapenems Monobactam Aminoglycosides Tetracyclime (mostly) Chloramphenicol Daptomycin (mostly) TMP-SMX Quinolones (and biliary) Vancomycin |
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