592771
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| SecY | Ubiquitous protein that uses SecYeg channels in the membrane to secrete proteins |
| TAT (Twin Argernine System) | Transport of fully folded proteins (inner membrane only) |
| Secretion Systems (Types I-IV & VI) | Inner & Outer Membrane transport (can be Sec independent or Sec requiring) |
| Type V Autotransporter | Like Types 1-IV & VI, often encoded by pathogenicity islands |
| SecY- Protein Sorting/Targeting | An N-terminal targeting signal sequence |
| SecY- SecB | For exported proteins |
| SecY- SRP | Signal recognition particle (for membrane proteins) |
| SecY- Translocation Protein Channel | SecY, E and Gamma |
| SecY-SecA | ATPase that provides energy for translocation |
| SecY- Release | Signal sequence is cleaved by peptidases and proteins fold |
| SecY-Channel | Occurs as a partially active dimer (one monomer active, one inactive) |
| 1) Sec B dimer binds the protein and... | brings it to SecY channel |
| 2) The 'plug' keeps SecY closed until... | it interacts with the signal sequence |
| 3) ATP hydrolysis causes.... | SecA to pump the protein through the SecY channel |
| SecB Dependent- Destination | Outside of the cell or the outer cell membrane |
| SecB Dependent- Is the protein folded | No |
| SecB Dependent- Channel Target | Sec A |
| SRP Dependent- Destination | Membrane itself |
| SRP Dependent- Ribosome binding | Yes |
| SRP Dependent- Channel Target | FTSY |
| SRP Dependent- Folded | No- is translated directly through channel |
| Sec Y Signal Peptide- Length | 25 amino acids |
| Sec Y Signal Peptide- N Region | +ve |
| Sec Y Signal Peptide- H Region | Hydrophobic |
| Sec Y Signal Peptide- C Region | AXA sequence immediately preceeding cleavage site |
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