Neurophysiology of Pain: Neuroregulators - Neurotransmitters (Excitatory)

Question	Answer
Prostaglandins	1. Generated from the breakdown of phospholipids and cell membranes 2. Thought to increase sensitivity to pain
Bradykinin	1. Released from plasma that leaks from surrounding blood vessels at the site of tissue injury 2. Binds to receptors on peripheral nerves, increasing pain stimuli 3. Binds two cells that cause a chain reaction producing prostaglandins
Substance P	1. Found in pain neurons of dorsal horn (excitatory peptide) 2. Needed to transmit pain impulses from periphery to higher brain centers. 3. Causes vasodilation and edema
Histamine	Produced by mast cells causing capillary dilation and increased capillary permeability
Serotonin	Released from the brainstem and dorsal horn to inhibit pain transmission

Resource summary

	Created by Christian Cervan over 8 years ago