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NAFLD

Anatomy of the liver
Histology of the liver
Lipid Metabolism
1. A. Transport of acetyl COA into cytosol B. Carboxylation of acetyl COA C. Assembly of FA chain
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat is stored in the liver with the absence of significant alcohol intake.
Risk factors
1. Obesity, Diabetes Mellitus, Hypertriglyceridemia, Surgery (Jejunoileal Bypass), Medications (Corticosteroids, Estrogens, Amiodarone), Exposures to organic solvents.
Signs & Symptoms
1. Elevation of serum transaminases, fatigue, malaise, right upper quadrant discomfort.
2. Most are asymptomatic
Causes
1. Metabolic syndrome
  1. defined as having at least two of the following: obesity, insulin resistance, dyslipidemia, and hypertension
Investigation
1. Waist to hip ratio (WHR)
2. Physical examination
3. Complete blood count
4. Lipid profile
5. AST and ALT enzymes
6. X-Ray of abdomen
Complications
1. cirrhosis, liver failure, liver cancer, edema and ascites, hepatic encephalopathy, hepatorenal syndrome, hepatopulmonary syndrome, hypersplenism, bacterial peritonitis.
Management
1. Pharmacological
  1. Orlista, Lorcaserin, phentermine-topiramate, Liraglutide.
2. Bariatric surgery
Affected by
1. Types of Diets
  1. Atkins Diet
  2. Nutrisystem Diet

NAFLD

	Created by mohammed mansour over 6 years ago