2727873
Description
Mind Map by Alix Stonehouse, updated more than 1 year ago
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Created by Alix Stonehouse
over 9 years ago
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ENDOCRINOLOGY (growth
hormone)
- Growth Hormone (GH)
- Released from the anterior
pituitary in response to
growth hormone releasing
hormone (GHRH) signals
- Pulsatile release pattern
- Growth hormone releasing
hormone antagonised by insulin
and growth hormone inhibiting
hormone
- Pulsatile release pattern
- Somatostatin inhibits growth hormone
- Effects include causing the liver to secrete
somatomedins/insulin like growth factors. These
cause uptake of amino acids and their incorporation
into proteins
- Stimulates stem cell divisions in
chrondrocytes (cartilage). The increased
daughter cells ted to grow by
somatomedins
- Stimulates stem cell divisions in
chrondrocytes (cartilage). The increased
daughter cells ted to grow by
somatomedins
- Glucose sparing agent - causes lipolysis
so that glycerol can be used to make
glucose and glucose can be used by the
brain
- Defects
- Dwarfism
- Deficient GH secretion, higher
than normal body fat
- Treated by synthetic growth hormone
- Deficient GH secretion, higher
than normal body fat
- Gigantism
- Excess GH secretion in adolesence
- Treated with sympathetic
somatostatin that inhibits
growth hormone
- Excess GH secretion in adolesence
- Acromegaly
- Excess GH secretion in
adulthood. May be due to
pituitary tumours. Causes jaw
extension
- Treated with sympathetic somatostatin that
inhibits growth hormone or surgical removal
of tumours
- Excess GH secretion in
adulthood. May be due to
pituitary tumours. Causes jaw
extension
- Dwarfism
- Synthetic human growth
hormone causes
anti-catabolic effects of
protein in the liver, bone
elongation, decreased glucose
and fat storage
- Lean body mass and total body
weight increase but no difference to
strength
- Can cause diabetes due to insulin
resistance, arthritis, large fingers
and toes, cardioomegaly and
increased muscle weakness
- Lean body mass and total body
weight increase but no difference to
strength
- Released from the anterior
pituitary in response to
growth hormone releasing
hormone (GHRH) signals
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