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419953
Non-Narcotic Analgesics
Description
(DHYG 325- Pharmacology) Mind Map on Non-Narcotic Analgesics, created by fandrickb2 on 05/12/2013.
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dhyg 325- pharmacology
dhyg 325- pharmacology
Mind Map by
fandrickb2
, updated more than 1 year ago
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fandrickb2
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Resource summary
Non-Narcotic Analgesics
Salicylates : ASA
inhibits COX1 enzyme, inhibits PG production in response to inflammation
more effective on throbbing pain- inflammation response ex. after an extraction.
mild-moderate pain
reduces fever
antiinflammatory
ANTIPLATELET: irriversible, inhibits thromboxane
used in prophylaxis of MI
DOSE: 325-650mg q4h (pain
3-6g daily for arthritis
75-325mg prevention MI
children 10-15mg/kg q4-6hr
ADRs: GI: PG responsible for production of protective mucus in gut & inhibiting gastric acid secretion
Blood clotting: prolongs bleeding 1.5-7 days (depending on dose)
High doses: tinnitus, Nausa, vomitting. hyperventilation=death soon
aggrivate ulcers, gastritis, hernia, GERD
hypersensitivity triad: sensitivity, nasal polyps & athsma
NSAIDs
Attachments:
NSAIDs
Similar to ASA, but more POTENT. reversible platelet aggregation (only as long as its in the blood)
uses: rheumatoid, gouty & osteoarthritis, fever, dysmenorrhea & assoc. pain
COX1 present in body at all times, SE assoc w GI, remal function, fluid retention & platelet adhesion
COX2 present only during trauma, high CV events assoc with COX2 inhibitors, only celebrex/celexicob available
Acetaminophen
Equipotent as ASA. Tylonel, Tempra, Panadol. Caffeine usually added
Provides NO ANTIINFLAMMATORY,
amtipyretic & analgesic. No effect on CV or resp. syste,.
Metabolized in liver, avoid use with alcohol or in pts with liver problems
DOSE: 325-650mg q4-6hr to max of 4g/24hr
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