5281923
Description
Mind Map by Nurainaa Azra'i, updated more than 1 year ago
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Created by Nurainaa Azra'i
over 8 years ago
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ADAPTIVE IMMUNE RESPONSE
- Details:
- Innate vs Adaptive
- Non-specific vs Specific
- Immunological memory is not stored vs Immunological memory is stored
- Innate vs Adaptive
- 1. Development of T and B cells
- Lymphocyte: T cells( thymus ), B cells( bone marrow )
- Have surface markers/receptors: 1. bind to receptors on other cells 2. Bind to antigens 3. Transmit and receive messages
- Common receptor: 1. MHC 2. CD 3. Antigen-specific receptors
- MHC class: Class I, Class II (the focus), Class III
- CD Molecules: CD4 for Class II, CD8 for Class I
- Clonal Deletion
- Lymphocyte: T cells( thymus ), B cells( bone marrow )
- 2. Presentation of antigens
- Happen in secondary lymphoid organ
- Antigens is substance that provoke immune response
- Have epitope- antigenic determinant site
- Combination factors: size, complexity, foreigness
- APC's: macrophages, dendritic cells, B cells
- T cells- T receptors (TCR)
- B cells- immunoglobulins (Ig) / antibodies: Ig G, Ig A, Ig M, Ig E, Ig D
- Happen in secondary lymphoid organ
- T-cell response
- differentiation: 1. subtypes of T helper cells (Th), 2. memory T cells, 3. regulatory T cells, 4. cytotoxic T cells
- CD 8: cytotoxic T cells attack * infected host * cancerous host cells * foreign cells from outside
- CD 4: helper T cells stimulate or activate other cells * macrophage * B cells * T cells
- differentiation: 1. subtypes of T helper cells (Th), 2. memory T cells, 3. regulatory T cells, 4. cytotoxic T cells
- B-cell response
- T-independent cells activation ( just small amount)
- Differentiation: memory B cells, neutralisation, antitoxin action
- T-independent cells activation ( just small amount)
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