Receptors

Receptors

1. Ionotropics

   • The receiver is associated physically to an ion channel
     • Or form part of it
       • Multimeric structure composed of several subunits
         • Cholinergic receptor
           • GABA Receptor
           • Glycine receptor
         • Glutamate
           • NMDA
           • AMPA
           • Kainate
         • Purinergic
           • Activated by ATP
         • Nicotinic
           • It allows the passage of cations Na/k /Ca2
             • Despolarization
               • Acts as Activator
           • The receiver allows the passage of anions Cl-/ HCO3
             • Hyperpolarization
               • Acts as inhibitor
     • Ionic channel specific to certain ions
     • Responds faster

2. Metabotropic

   • They are bonded to G proteins
     • When the ligand binds to the receptor activates the G protein
       • The protein activate other seconds messengers
         • The messengers
           • Activates genes
           • Open ionices channels to produce the response
   • Responds more slowly

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