Sept 3rd 1928 - Old petri dishes,
previously covered in staphyloccus
bacteria as part of research
One dish had mould in a ring shape.
The area around the ring seemed to
be free of the bacteria (staphyloccus) -
The mould was penicillium notatum
More research on this mould
found that it could kill other
bacteria and would not harm any
small animals when given to them
LOUIS PASTEUR
Contributed to germ theory
He showed the action of microorganisms on sugar leads to fermentation
He was convinced that any growth (e.g. mould that appeared on food that had
gone bad) were from microscopic organisms already present in the air
First he showed that his main rival's results were uncertain. Then he showed that when he boiled
broth and then sealed it immediately, the container would stay clear, however once he added
material that had been exposed to air, microorganisms grew in the broth and it turned cloudy
1845-6 A mystery disease wiped out silkworms around the world,
Pasteur showed that the disease was caused by microorganisms
which were only found in the tissues of diseased silkworms, moths
and eggs. They could be seen using a microscope
Three of Pasteur's daughters died of infectious diseases and he mused these
diseases and worked on them to confirm that they were caused by germs
(microorganisms) and he developed vaccines against a number of these diseases
JOSEPH LISTER
Moved to Glasgow in 1860 and
became a professor of surgery
He read Pasteur's work and decided to experiment using one
of his proposed techniques - exposing a wound to chemicals
Dressings soaked in carbolic acid reduced infection rate dramatically. Hand washing,
sterilising instruments and spraying carbolic acid in the operating theatre limited infection
Good lowered infection rate, his principles were adopted throughout many countries - He is
now known as the 'father of antiseptic sugery'