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684200
Hemolytic Anemias
Description
Notes from Doctors in Training
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step 1 prep
usmle step 1
step 1 prep
Mind Map by
snlogel
, updated more than 1 year ago
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Created by
snlogel
over 10 years ago
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Resource summary
Hemolytic Anemias
Intravascular hemolysis
Paroxysmal nocturnal hemoglobinuria
Missing CD55 and CD59
Positive Ham's test
Autoimmune hemolytic anemia
Mechanical destruction
Extravascular hemolysis
Hereditary spherocytosis
Ankyrin
Spectrin
Increased MCHC and RDW
Splenomegaly
Aplastic crises due to parvovirus B19
Osmotic fragility test
Splenectomy
G6PD deficiency
Sensitive to oxidative stress
Sulfa drugs
Fava beans
Infections
Heinz bodies
Pyruvate kinase deficiency
RBCs cannot generate ATP
Swelling and hemolysis of the red cells
Sickle cell disease
Low oxygen tension
Dehydration
Complications
Sequestration crisis
Autosplenectomy
Salmonella osteomyelitis
Aplastic criss due to parvovirus B19
Pain crises due to vasoocclusion
Renal papillary necrosis due to hypoxemia
Treatment
Hydroxyurea
Bone marrow transplantation
Hemoglobin C disease
Heterozygous: asymptomatic
Homozygous: mild hemolysis and splenomegaly
SC disease
Warm agglutinins (IgG antibodies)
Lupus
CLL
Drugs
Cold agglutinins (IgM antibodies)
CLL
Mycoplasma infections
Infectious mononucleosis
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