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Ahmed's frequent infections

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Mind Map on Ahmed's frequent infections, created by Safaa Fayiz on 26/11/2016.
Safaa Fayiz
Mind Map by Safaa Fayiz, updated more than 1 year ago
Safaa Fayiz
Created by Safaa Fayiz about 8 years ago
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Resource summary

Ahmed's frequent infections
  1. types of immunodeficiency
    1. Primary ID
      1. SCID
        1. Both B and T cells are affected
          1. caused by
            1. mutations in genes
            2. types
              1. classical X-linked
                1. ADA difeciny
                  1. Autosomal disorder
                    1. lack of adenosine deaminase
                      1. nodded on chromosome 20
                        1. diagnosed by
                          1. lymphopenia
                            1. low Ig
                              1. low level of t, b cells and NK
                          2. treatment
                            1. preventing infections
                              1. transplant
                                1. Bone marrow transplant
                                  1. taking healthy stem cells from the bone marrow and transfer them to another
                                    1. required HLA typing
                                      1. methods
                                        1. serology
                                          1. mixed lymphocyte culture
                                            1. molecular Assays
                                      2. gene therapy
                                        1. enzyme therapy
                                      3. disorder of T celss
                                        1. T cells deficiency with variable B-cells
                                          1. Disorder of B-Cells
                                            1. Non-specific immune system
                                              1. Complements disorder
                                                1. lab investigation
                                                  1. CBC
                                                    1. B- cells defect
                                                      1. phagocytic cells defects
                                                        1. T-cells defects
                                                          1. complement defects
                                                          2. prenatal diagnosis & carrier detection
                                                            1. cord blood sampling
                                                              1. CBC
                                                                1. WBC
                                                                2. chronic villus sampling
                                                                  1. enzyme analysis amnion cells
                                                                3. Secondry ID
                                                                  1. AIDS
                                                                    1. aging
                                                                      1. Malignancies
                                                                        1. other conditions
                                                                          1. DM
                                                                            1. Sickle-cell anemia
                                                                              1. burns
                                                                                1. alcoholism
                                                                            2. Hypersensitivity
                                                                              1. Type 1
                                                                                1. anaphylactic
                                                                                  1. by - IgE ABs
                                                                                    1. either localized or systemic 15-30 mins
                                                                                2. type 2
                                                                                  1. cytotoxic
                                                                                    1. by- IgG , IgM ABs
                                                                                      1. cytotoxic reaction mins - hours
                                                                                  2. type 3
                                                                                    1. immune complex
                                                                                      1. by- IgG , IgM
                                                                                        1. complement & neutrophils 3- 8 hours
                                                                                    2. type 4
                                                                                      1. delayed type
                                                                                        1. cell mediated
                                                                                          1. eczema & local induration 48-72 hours
                                                                                    3. organ rejection
                                                                                      1. types
                                                                                        1. Hyperacute rejection
                                                                                          1. Acute rejection
                                                                                            1. chronic rejection
                                                                                            2. Treatment
                                                                                              1. Immunosuppresive therapy
                                                                                                1. Antibody-based treatments
                                                                                                  1. blood transfer
                                                                                                    1. marrow transplant
                                                                                                  2. Demographics
                                                                                                    1. Ahmed
                                                                                                      1. Male
                                                                                                        1. nine months old
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