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8700918
I always feel tired
Description
Mind Map on I always feel tired, created by leen abuafifeh on 27/04/2017.
Mind Map by
leen abuafifeh
, updated more than 1 year ago
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Created by
leen abuafifeh
over 7 years ago
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Resource summary
I always feel tired
diagnosed with
Fe deficiency anemia
anemia
Normocytic
increased destruction (hemolytic anemia)
Hereditary spehrocytosis
Sickle cell anemia
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Paroxysmal Nocturnal Hemoglobeinuria
MCV: >100um3
Macrocytic
Megaloblastic anemia
VB 12 deficiency
symptoms of VB12 DEF
Nerve damage.
Neurological problems
Nausea and vomiting
enlarged liver
smooth, beefy red tongue
CAUSES
vegan
Impaired absorption
Intrinsic factor deficiency (prenicious anemia- gastrectomy
Malabsorption diseases (pancreatic insufficiency)
Diffuse intestinal disease (lymphoma-Crohn’s
Competitive parasitic uptake (tape worm infestation)
folate deficiency
Increased homocysteine level
Normal mehylmalonic acid
CAUSES
Dietary deficiency (alcohol-elderly)
Increased demand pregnancy- cancer patients
Impaired DNA synthesis
Ineffective erythropoiesis
Non-megaloblastic anemia
Alcoholism
Drugs (Ex- 5 FU)
Liver disease
SYMPTOMPS OF ANEMIA
MCV: <80
Microcytic
Anemia of chronic disease
TB
Rheumatoid arthritis
Malignancy
Chronic alcoholism
Iron is trapped in BM macrophages
HEPCIDIN prevents the release of iron from BM
decrese EPO production
Increase in BM iron stores
Sideroblastic
Chronic alcoholism
VB6 deficiency
Lead poisoning
INH therapy
Hereditary types (x- linked)
Free iron accumulates inside the mitochondria (Iron loaded mitochondria in the bone marrow erythroblasts)
RING SIDEROBLASTS
Risk factors
Women
Infants and children
Vegetarians
Frequent blood donors
Complications
Heart problems
Problems during pregnancy
Growth problems
Treatment
Oral or parenteral iron preparations
pyridoxine
Hydroxyurea
Pentoxifylline
RBC
HB
Transport of O2 from lungs to tissues &CO2 and H+ from tissues to the lungs for excretion
HEME
porphyrin ring with central iron
. Iron is the site of attachment with O2.
4 heme groups
4 O2 molecules
Iron
immune system healthy
produce the connective tissue
STORED
Ferritin
TRASPORTED
Transferrin
GLOBIN
Microcytic hypochromic
C/P
General features of anemia
Epithelial atrophy- Plummer Vinson syndrome
Koilonichia
Pica
causes
increased loss
dietary deficiency
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