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PHSI3011 02-2 Cardiac Electrophysiology #1 - Ventricular action potential

Michael Jardine 7 questions

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  1. 1The Ventricular Action Potential duration is:
    1. A~300 ms; ~100X longer than APs in nerves and skeletal muscle.
    2. B~300 ms; roughly equal to APs in nerves and skeletal muscle.
    3. C~300 ms; ~100X shorter than APs in nerves and skeletal muscle.
    4. D3-4 ms; ~100X longer than APs in nerves and skeletal muscle.
    5. E3-4 ms; roughly equal to APs in nerves and skeletal muscle.
    6. F3-4 ms; ~100X shorter than APs in nerves and skeletal muscle.
  2. 2What is ICa?
    1. AIntracellular [Ca]
    2. BInside [Ca]
    3. CInward [Ca] current
    4. DIntracellular [Ca], measured relative to extracellular [Ca]
  3. 3There are three main functions of ICa. These are?
    (select all that apply)
    1. AProvides inward current, which helps maintain long AP.
    2. BProvides a small fraction of the Ca, which triggers contraction.
    3. CTriggers Ca release from the SR (through the process of CICR - Calcium-Induced Calcium Release).
    4. DHelps marble meat properly.
  4. 4Do Potassium channels contribute to the long action potential?
    1. AYes
    2. BNo
  5. 5Potassium channels are largely responsible for which of the following?
    (not necessarily their only role, though)
    1. ADepolarisation
    2. BRepolarisation
    3. C[none of the above]
  6. 6K[ATP] channels ("ATP" should be subscript) are:
    1. APotassium-induced ATP channels.
    2. BATP-induced Potassium channels.
    3. CLack-of-Potassium -induced ATP channels.
    4. DLack-of-ATP -induced Potassium channels.
  7. 7Ischaemia is [blank_start]____[blank_end] of blood flow
    1. Arestriction
    2. Ban excess

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Description
Cardiac Electrophysiology divided into two lectures: 1 - Ventricular action potential (this one) 2 - Pacemaker action potentials Outline: - During exercise, the heart increases CO (Cardiac Output) - This is achieved by increasing HR and SV (Heart Rate and Stroke Volume) - These two lectures are devoted to the electrophysiological aspects of these changes - For most of us the terminal event will be a cardiac arrhythmia...but what causes them?
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