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1807NRS Safe Administration of Medications 1

Description

End of Trimester 2, 2017 Quiz
Kathleen Jackson
Quiz by Kathleen Jackson, updated more than 1 year ago
Kathleen Jackson
Created by Kathleen Jackson almost 7 years ago
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Resource summary

Question 1

Question
Pharmacokinetics is:
Answer
  • The study of biological and therapeutic effects of drugs
  • The study of absorption, distribution, metabolism and excretion of drugs
  • The study of mechanisms of drug action
  • The study of methods of new drug development

Question 2

Question
What does “pharmacokinetics” include?
Answer
  • Complications of drug therapy
  • Drug biotransformation in the organism
  • Influence of drugs on metabolism processes
  • Influence of drugs on genes

Question 3

Question
What does “pharmacokinetics” include?
Answer
  • Pharmacological effects of drugs
  • Unwanted effects of drugs
  • Chemical structure of a medicinal agent
  • Distribution of drugs in the organism

Question 4

Question
The main mechanism of most drugs absorption in GI tract is:
Answer
  • Active transport (carrier-mediated diffusion)
  • Filtration (aqueous diffusion)
  • Endocytosis and exocytosis
  • Passive diffusion (lipid diffusion)

Question 5

Question
What kind of substances can’t permeate membranes by passive diffusion?
Answer
  • Lipid-soluble
  • Non-ionized substances
  • Hydrophobic substances
  • Hydrophilic substances

Question 6

Question
A hydrophilic medicinal agent has the following property:
Answer
  • Low ability to penetrate through the cell membrane lipids
  • Penetrate through membranes by means of endocytosis
  • Easy permeation through the blood-brain barrier
  • High reabsorption in renal tubules

Question 7

Question
What is implied by «active transport»?
Answer
  • Transport of drugs trough a membrane by means of diffusion
  • Transport without energy consumption
  • Engulf of drug by a cell membrane with a new vesicle formation
  • Transport against concentration gradient

Question 8

Question
What does the term “bioavailability” mean?
Answer
  • Plasma protein binding degree of substance
  • Permeability through the brain-blood barrier
  • Fraction of an uncharged drug reaching the systemic circulation following any route administration
  • Amount of a substance in urine relative to the initial doze

Question 9

Question
The reasons determining bioavailability are:
Answer
  • Rheological parameters of blood
  • Amount of a substance obtained orally and quantity of intakes
  • Extent of absorption and hepatic first-pass effect
  • Glomerular filtration rate

Question 10

Question
Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimised:
Answer
  • Oral
  • Transdermal
  • Rectal
  • Intraduodenal

Question 11

Question
Which route of drug administration is most likely to lead to the first-pass effect?
Answer
  • Sublingual
  • Oral
  • Intravenous
  • Intramuscular

Question 12

Question
What is characteristic of the oral route?
Answer
  • Fast onset of effect
  • Absorption depends on GI tract secretion and motor function
  • A drug reaches the blood passing the liver
  • The sterilisation of medicinal forms is obligatory

Question 13

Question
Tick the feature of the sublingual route:
Answer
  • A drug has a pretty fast absorption
  • A drug is exposed to gastric secretion
  • A drug is exposed more prominent liver metabolism
  • A drug can be administrated in a variety of doses

Question 14

Question
Pick out the parenteral route of medicinal agent administration:
Answer
  • Rectal
  • Oral
  • Sublingual
  • Inhalation

Question 15

Question
Parenteral administration:
Answer
  • Cannot be used with unconsciousness patients
  • Generally results in a less accurate dosage than oral administration
  • Usually produces a more rapid response than oral administration
  • Is too slow for emergency use

Question 16

Question
What is characteristic of the intramuscular route of drug administration?
Answer
  • Only water solutions can be injected
  • Oily solutions can be injected
  • Opportunity of hypertonic solution injections
  • The action develops slower, than at oral administration

Question 17

Question
Intravenous injections are more suitable for oily solutions:
Answer
  • True
  • False

Question 18

Question
Correct statements listing characteristics of a particular route of drug administration include all of the following EXCEPT:
Answer
  • Intravenous administration provides a rapid response
  • Intramuscular administration requires a sterile technique
  • Inhalation provides slow access to the general circulation
  • Subcutaneous administration may cause local irritation

Question 19

Question
Most of drugs are distributed homogeneously.
Answer
  • True
  • False

Question 20

Question
Biological barriers include all except:
Answer
  • Renal tubules
  • Cell membranes
  • Capillary walls
  • Placenta

Question 21

Question
What is the reason of complicated penetration of some drugs through brain-blood barrier?
Answer
  • High lipid solubility of a drug
  • Meningitis
  • Absence of pores in the brain capillary endothelium
  • High endocytosis degree in a brain capillary

Question 22

Question
The volume of distribution (Vd) relates:
Answer
  • Single to a daily dose of an administrated drug
  • An administrated dose to a body weight
  • An uncharged drug reaching the systemic circulation
  • The amount of a drug in the body to the concentration of a drug in plasma

Question 23

Question
For the calculation of the volume of distribution (Vd) one must take into account:
Answer
  • Concentration of a substance in plasma
  • Concentration of substance in urine
  • Therapeutical width of drug action
  • A daily dose of drug

Question 24

Question
A small amount of the volume of distribution is common for lipophylic substances easy penetrating through barriers and widely distributing in plasma, interstitial and cell fluids:
Answer
  • True
  • False

Question 25

Question
The term “biotransformation” includes the following:
Answer
  • Accumulation of substances in a fat tissue
  • Binding of substances with plasma proteins
  • Accumulation of substances in a tissue
  • Process of physicochemical and biochemical alteration of a drug in the body

Question 26

Question
Biotransformation of the drugs is to render them:
Answer
  • Less ionized
  • More pharmacologically active
  • More lipid soluble
  • Less lipid soluble

Question 27

Question
Tick the drug type for which microsomal oxidation is the most prominent:
Answer
  • Lipid soluble
  • Water soluble
  • Low molecular weight
  • High molecular weight

Question 28

Question
Pick out the right statement:
Answer
  • Microsomal oxidation always results in inactivation of a compound
  • Microsomal oxidation results in a decrease of compound toxicity
  • Microsomal oxidation results in an increase of ionization and water solubility of a drug
  • Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated

Question 29

Question
Stimulation of liver microsomal enzymes can:
Answer
  • Require the dose increase of some drugs
  • Require the dose decrease of some drugs
  • Prolong the duration of the action of a drug
  • Intensify the unwanted reaction of a drug

Question 30

Question
Metabolic transformation (phase 1) is:
Answer
  • Acetylation and methylation of substances
  • Transformation of substances due to oxidation, reduction or hydrolysis
  • Glucuronide formation
  • Binding to plasma proteins

Question 31

Question
Biotransformation of a medicinal substance results in:
Answer
  • Faster urinary excretion
  • Slower urinary excretion
  • Easier distribution in organism
  • Higher binding to membranes

Question 32

Question
Conjugation is:
Answer
  • Process of drug reduction by special enzymes
  • Process of drug oxidation by special oxidases
  • Coupling of a drug with an endogenous substrate
  • Solubilization in lipids

Question 33

Question
Which of the following processes proceeds in the second phase of biotransformation?
Answer
  • Acetylation
  • Reduction
  • Oxidation
  • Hydrolysis

Question 34

Question
Metabolic transformation and conjugation usually results in an increase of a substance biological activity:
Answer
  • True
  • False

Question 35

Question
In case of liver disorders accompanied by a decline in microsomal enzyme activity the duration of action of some drugs is:
Answer
  • Decreased
  • Enlarged
  • Remained unchanged
  • Changed insignificantly

Question 36

Question
Half life (t ½) is the time required to:
Answer
  • Change the amount of a drug in plasma by half during elimination
  • Metabolize a half of an introduced drug into the active metabolite
  • Absorb a half of an introduced drug
  • Bind a half of an introduced drug to plasma proteins

Question 37

Question
Half life (t ½) doesn’t depend on:
Answer
  • Biotransformation
  • Time of drug absorption
  • Concentration of a drug in plasma
  • Rate of drug elimination

Question 38

Question
Elimination is expressed as follows:
Answer
  • Rate of renal tubular reabsorption
  • Clearance speed of some volume of blood from substance
  • Time required to decrease the amount of drug in plasma by one-half
  • Clearance of an organism from a xenobiotic

Question 39

Question
The most rapid eliminated drugs are those with high glomerular filtration rate and actively secreted but aren’t passively reabsorbed:
Answer
  • True
  • False

Question 40

Question
Systemic clearance (CLs) is related with:
Answer
  • Only the concentration of substances in plasma
  • Only the elimination rate constant
  • Volume of distribution, half life and elimination rate constant
  • Bioavailability and half life
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