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Lecture 3 - GFR

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- Renal physiology Quiz on Lecture 3 - GFR, created by Alannah McDonnell on 04/04/2018.
Alannah McDonnell
Quiz by Alannah McDonnell, updated more than 1 year ago
Alannah McDonnell
Created by Alannah McDonnell over 6 years ago
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Resource summary

Question 1

Question
What is normal GFR in adult humans?
Answer
  • 100-125 ml/min
  • 4500-6000 ml/min
  • 1 - 2 ml/min
  • 540 - 900 ml / min

Question 2

Question
What does glomerular ultra-filtrate consist of?
Answer
  • water
  • small solutes
  • large solutes
  • plasma
  • urine

Question 3

Question
Glomerular Ultrafiltrate is normally ...
Answer
  • containing proteins
  • protein free

Question 4

Question
What does Regulated reabsorption of water and solutes allow for?
Answer
  • regulation of extracellular fluid volume
  • regulation of osmolality
  • regulation of acid base balance
  • homeostasis of whole body phosphate concentrations
  • homeostasis of whole body calcium concentrations
  • homeostasis of whole body potassium concentrations

Question 5

Question
Which of these are freely filtered but not reabsorbed?
Answer
  • urea
  • creatinine
  • water
  • salt
  • proteins

Question 6

Question
Permselectivity = the restriction of the [blank_start]permeation[blank_end] of [blank_start]macromolecules[blank_end] across [blank_start]the glomerular barrier[blank_end] on the basis of [blank_start]molecular[blank_end] size, charge, and physical [blank_start]configuration.[blank_end]
Answer
  • permeation
  • permeability
  • macromolecules
  • micromolecules
  • the glomerular barrier
  • bowmans space
  • molecular
  • atomic
  • configuration.
  • conglobulation.

Question 7

Question
Podocytes = [blank_start]specialized[blank_end], highly [blank_start]differentiated[blank_end] cells which line the [blank_start]outside[blank_end] of glomerular [blank_start]capillaries[blank_end] and thus face the [blank_start]Bowman's space[blank_end] and the primary [blank_start]urine[blank_end]
Answer
  • specialized
  • common
  • differentiated
  • similar
  • outside
  • inside
  • capillaries
  • vessels
  • Bowman's space
  • glomerulus
  • urine
  • urea

Question 8

Question
Podocytes have a ____ cell body
Answer
  • large
  • small
  • average sized

Question 9

Question
The diaphragm in the podocyte covers the...
Answer
  • filtration slit
  • fenestration
  • foot process
  • whole cell body

Question 10

Question
What type of collagen composes the backbone of the fibrous network in the glomerular basement membrane?
Answer
  • type 1 collagen
  • type 2 collagen
  • type 3 collagen
  • type 4 collagen

Question 11

Question
What is the normal urine flow rate in adult humans?
Answer
  • 1 - 2 ml/min
  • 100-125ml/min
  • 540-900 ml/min
  • 900-1500ml/min

Question 12

Question
What is the normal renal blood flow rate in adult humans?
Answer
  • 900-1500 ml/min
  • 4500 - 6000 ml/min
  • 540-900 ml/min
  • 1-2 ml/min

Question 13

Question
What is the normal renal plasma flow rate in adult humans?
Answer
  • 540-900 ml/min
  • 4500-6000 ml/min
  • 900 - 1500 ml/min
  • 1-2ml/min

Question 14

Question
what does the filtration fraction generally measure?
Answer
  • 20-25%
  • 40-45%
  • 50-60%
  • 80-85%

Question 15

Question
Roughly how much primary urine is produced per day?
Answer
  • 140L
  • 200L
  • 140ml
  • 500L
  • 10L

Question 16

Question
Roughly how much filtered fluid is reabsorbed?
Answer
  • 99%
  • 1%
  • 20%
  • 50%
  • 75%

Question 17

Question
Drag and drop the right answer. all answers match up with a space, there are none spare. For the 0 options, the 00 is in the % column and the normal 0 is in the urine column)
Image:
Untitled (binary/octet-stream)
Answer
  • 17
  • 0.63
  • 0.5
  • 12.9
  • 125
  • 33
  • 1.4
  • 0.128
  • 0.06
  • 0.0048
  • 0.134
  • 0
  • 18
  • 1.8
  • 0.72
  • 9.5
  • 0.96
  • 1
  • 00
  • 55
  • 130

Question 18

Question
drag and drop
Image:
Untitled (binary/octet-stream)
Answer
  • Proximal convoluted tubule
  • glomerulus
  • Glomerular capsule
  • efferent arteriole
  • blood flow
  • afferent arteriole
  • glomerular filtrate
  • fenestrae
  • podocyte
  • capillary endothelium

Question 19

Question
Glomerular capillaries are __________
Answer
  • fenestrated
  • continuous

Question 20

Question
Endothelial cells _______ determine the permselectivity of the glomerular barrier.
Answer
  • do
  • do not

Question 21

Question
The endothelial cell coat has _________
Answer
  • charge-selective properties
  • no charge-selective properties.
  • size selective properties
  • molecular weight selective properties

Question 22

Question
___________ density of fenestrae facilitates ___________ permeability
Answer
  • high, high
  • low, low
  • high, low
  • low, high

Question 23

Question
Which of these are important components that contribute to the selective properties of the glomerular basement membrane barrier?
Answer
  • ptoteoglycans such as agrin
  • ptoteoglycans such as perlecan
  • glycoproteins

Question 24

Question
Where is the endothelial cell surface layer?
Answer
  • on the luminal side of the blood vessels
  • on the fenestrated side of the blood vessels
  • on the outside of the blood vessels
  • within the glomerulus

Question 25

Question
What are the 2 components of the endothelial cell surface layer?
Answer
  • the glycocalyx
  • the endothelial cell coat
  • the endometrial cell jacket
  • the caloglycax
  • the glucose layer

Question 26

Question
Thye glycocalyx is the...
Answer
  • plasma-membrane-bound part of the layer
  • the more loosely associated part of the layer

Question 27

Question
Thye endothelial cell coat is the...
Answer
  • more loosely associated part of the layer
  • plasma-membrane-bound part of the layer

Question 28

Question
*** The endothelial cell surface layer is composed of....
Answer
  • negatively charged glycoproteins
  • glycosaminoglycans
  • membrane associated and secreted proteoglycans

Question 29

Question
drag and drop the substances along the graph in relation to where there relative permeability lies
Image:
Untitled (binary/octet-stream)
Answer
  • H2O
  • NaCl
  • Glucose
  • Inulin
  • Myoglobin
  • Hemoglobin
  • Albumin

Question 30

Question
Filtration of solutes that are not reabsorbed serves as an ineffective mechanism for their excretion
Answer
  • True
  • False

Question 31

Question
Which of these about polo trees are true?
Answer
  • Have long extending cytoplasmic foot processes
  • Foot processes are separated by a filtration slit
  • The filtration slit is 25-60nm wide
  • The filtration slit is covered by a diaphragm
  • One of the proteins that make up the diaphragm is nephrin
  • Nephrin is very safe

Question 32

Question
When mutated, nephrin...
Answer
  • Causes massive leakage of protein
  • Causes severe consequences for patients with congenital nephrotic syndrome.
  • Causes the diaphragm in the kidney to close
  • Causes excess water to be absorbed
  • Causes alcoholism

Question 33

Question
The basement membrane allows free passage of neutral molecules up to...
Answer
  • 6Kd MW (18A radius)
  • 16Kd MW (8A radius)
  • 12Kd MW (24A radius)
  • 2A MW (7Kd radius)

Question 34

Question
Negatively charged pores restrict passage of .... molecules
Answer
  • Large
  • Small
  • Medium
  • Long
  • Short

Question 35

Question
In disease states, protein Irial may be due to loss of negatively charge selectivity or to increasing numbers of large size pores
Answer
  • True
  • False
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