Message from brain or spinal cord to the muscles, organs is [blank_start]efferent[blank_end].
Message from receptors to the brain or spinal cord is [blank_start]afferent[blank_end].
Interneuron relays between [blank_start]sensory and motor[blank_end] neurons.
Information flows from one neuron to another across a synapse, changing [blank_start]action potential[blank_end] to [blank_start]neurotransmitter[blank_end] and back.
• Target cell MORE likely to fire = [blank_start]excitatory[blank_end]
• Target cell LESS likely to fire = [blank_start]inhibitory[blank_end]
[blank_start]INTEGRATION[blank_end] = ‘decides’ whether to fire AP
[blank_start]Spatial[blank_end] summation: different locations at same time
[blank_start]Temporal[blank_end] summation: same place, slightly different times
Aspects of neurotransmission (synthesis, storage, release, reuptake) are affected by many drugs. General drug effects:
1. Storage
Facilitates storage (e.g., by acting as a precursor) – [blank_start]agonist[blank_end]
Inhibits storage (e.g.by inhibiting synthesis or by blocking storage into vesicles) – [blank_start]antagonist[blank_end]
2. Release
Increases release – [blank_start]agonist[blank_end]
Prevents release – [blank_start]antagonist[blank_end]
3. Reuptake/breakdown
Facilitates reuptake/breakdown - [blank_start]antagonist[blank_end]
Inhibits reuptake/breakdown - [blank_start]agonist[blank_end]
Answer
agonist
antagonist
antagonist
agonist
agonist
antagonist
antagonist
agonist
antagonist
agonist
agonist
antagonist
Question 5
Question
Drugs affecting dopaminergic neurons:
Synthesis - [blank_start]L-DOPA[blank_end] facilitates synthesis of DA by acting as a precursor - agonist
Storage - [blank_start]Reserpine[blank_end] blocks DA uptake into vesicles – antagonist
Action - [blank_start]Selegeline[blank_end] prolongs action of DA by blocking degradation (MAO-B inhibitor) - agonist
Release - Amphetamine increases release of DA - agonist
Reuptake - [blank_start]Cocaine[blank_end] and amphetamine blocks DA reuptake - agonist
Drugs affecting serotonergic(5-HT) neurons:
Synthesis - α-Methyltyrosine inhibits synthesis of 5-HT - antagonist
Release - [blank_start]Fenfluramine[blank_end] facilitates the release of 5-HT - agonist
Reuptake - [blank_start]Fluoxetine[blank_end] blocks reuptake of 5-HT- agonist