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Drug Targets - Receptors

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University Physiology and Pharmacology Quiz on Drug Targets - Receptors, created by Becca Shaw on 07/05/2015.
Becca Shaw
Quiz by Becca Shaw, updated more than 1 year ago
Becca Shaw
Created by Becca Shaw over 9 years ago
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Resource summary

Question 1

Question
Drugs are evenly distributed around the body. True or false?
Answer
  • True
  • False

Question 2

Question
Irreversible binding is mainly confined to what?
Answer
  • Receptor binding sites
  • Ion channels
  • Enzyme inhibitors
  • Transport/carrier proteins

Question 3

Question
Irreversible binding uses what type of bonding?
Answer
  • Covalent
  • Hydrogen
  • Ionic
  • Van der Waals

Question 4

Question
Which of the following are examples of natural binding sites?
Answer
  • Receptor binding sites
  • Modulatory sites
  • Allosteric sites
  • Enzyme active sites

Question 5

Question
Modulatory or allosteric sites are a type of separate site to which drugs can bind. True or false?
Answer
  • True
  • False

Question 6

Question
Drugs that block function are known as
Answer
  • Antagonists at receptors
  • Inhibitors at transporters/carriers
  • Blockers at ion channels
  • Inhibitors at enymes

Question 7

Question
What is the generic name for Adrenaline?
Answer
  • Fluoxetine
  • Noradrenaline
  • Epinephrine
  • Tetracycline

Question 8

Question
What is the generic name for Aspirin?
Answer
  • Mefanamic acid
  • Epinephrine
  • Diacetylmorphine
  • Acetylsalicylic acid

Question 9

Question
What is the generic name for Heroin?
Answer
  • Fluoxetine
  • Diacetylmorphine
  • Epinephrine
  • Acetylsalicylic acid

Question 10

Question
What is the generic name for Prozac?
Answer
  • Fluoxetine
  • Diacetylmorphine
  • Acetylsalicylic acid
  • Mefanamic acid

Question 11

Question
The use of an antagonist on a receptor results in
Answer
  • Enzyme activition
  • Opening of ion channels
  • No effect produced
  • Blockage of endognous mediators

Question 12

Question
What direct mechanism would an agonist have on a receptor molecule?
Answer
  • Enzyme activation or inhibition
  • Opening or closing of ion channels
  • Modulation of ion channels
  • DNA transcription

Question 13

Question
What transduction mechanisms may occur due to the activity of an agonist on a receptor molecule?
Answer
  • Ion channel modulation
  • DNA transcription
  • Enzyme inhibition or activation
  • Opening or closing of ion channel

Question 14

Question
Proteins that bind to specific molecules, called ligands, to produce a response are known as receptors. True or false?
Answer
  • True
  • False

Question 15

Question
When drugs act through receptors, these receptors will always have exogenous ligands. True or false?
Answer
  • True
  • False

Question 16

Question
Examples of endogenous ligands are
Answer
  • Hormones
  • Diacetylmorphine
  • Fluoxetine
  • Neurotransmitters

Question 17

Question
The endogenous ligand is always an agonist. True or false?
Answer
  • True
  • False

Question 18

Question
In the absence of ligands, receptors have no other function. True or false?
Answer
  • True
  • False

Question 19

Question
Where are most receptors found?
Answer
  • Embedded in the plasma membrane
  • Circulating in the blood
  • Lining the epithelium of the gut
  • In the brain

Question 20

Question
Which of the following statements are true regarding antagonists?
Answer
  • They bind loosely to receptors
  • The produce no effect themselves
  • They prevent agonists from binding
  • The block the response

Question 21

Question
Which of the following statements is false regarding Histamine?
Answer
  • It is an endogenous agonist
  • Binds to receptors on stomach parietal cells
  • Is an exogenous agonist
  • Causes release of gastric acid

Question 22

Question
Which of the following blocks the parietal histamine receptors?
Answer
  • Fluoxetine
  • Acetylcholine
  • Epinephrine
  • Ranitidine

Question 23

Question
Histamine receptor H1 mediates which effect on the gastrointestinal tract?
Answer
  • Inflammation
  • Bile secretion
  • Smooth muscle contraction
  • Gastric acid secretion

Question 24

Question
Histamine receptor H2 mediates which effect on the gastrointestinal tract?
Answer
  • Inflammation
  • Secretion of gastric acid
  • Bile secretion
  • Smooth muscle contraction

Question 25

Question
Which anatagonist acts upon Histamine receptor H2 to prevent secretion of gastric acid?
Answer
  • Ranitidine
  • Epinephrine
  • Acetylsalicylic acid
  • Mepyramine

Question 26

Question
Which antagonist acts upon Histamine receptor H1 to prevent contraction of smooth muscle in parietal cells?
Answer
  • Epinephrine
  • Ranitidine
  • Mepyramine
  • Fluoxetine

Question 27

Question
Different receptors for the same endogenous agonist are called subtypes. True or false?
Answer
  • True
  • False

Question 28

Question
Which of the following are a type of receptor family?
Answer
  • Ionotropic receptors (ligand-gated ion channels)
  • Kinase-linked receptors
  • Nuclear receptor (cytoplasmic)
  • Metabotropic receptors (G-protein coupled receptors)

Question 29

Question
Which of the following statements are true concerning ionotropic receptors?
Answer
  • Channel formed from 3-5 subunits
  • Pore domain of each subunit forms a hydrophobic channel
  • Ligands bind to an intracellular domain
  • Ions flow selectively through the membrane

Question 30

Question
The following is typical of the mechanism of receptors incorporating ion channels: 1. Agonist binds to receptor 2. Change in ion concentration in the cell 3. Depolarisation or hyperpolarisation occurs 4. Cellular effects (response)
Answer
  • True
  • False

Question 31

Question
Nicotinic acetylcholine receptor is a part of the ionotrophic receptor family. True or false?
Answer
  • True
  • False

Question 32

Question
Which of the following statements is false regarding Metabotropic receptors? (G-protein coupled receptors)
Answer
  • Consists of a single polypeptide
  • 7 transmembrane domains
  • Domains consist of beta helices
  • Ligand binds either to extracellular domain or within transmembrane domain

Question 33

Question
Muscarinic acetylcholine receptors are in the family of metabotropic receptors. True or false?
Answer
  • True
  • False

Question 34

Question
Alpha and beta adrenoceptors are examples of the 2nd messenger effects of GCPRs. True or false?
Answer
  • True
  • False
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