Question 1
Question
What stimulates the secretion of the CA's?
Question 2
Question
Once the membrane has been depolarised, what voltage gated channels open?
Question 3
Question
The influx of ions into the cell signals secretion by exocytosis
Question 4
Question
What is stored in Catecholamine vesicles, along with the CA?
Answer
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ATP
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ADP
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Fromogranin
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Chromogranin
Question 5
Question
ATP is -ve at body pH, whilst CA's are +ve
Question 6
Question
Why are CA's stored with these other substances?
Answer
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They keep the CA's out of solution
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They keep the CA's in solution
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Which helps prevent vesicle lysis due to osmotic pressure
Question 7
Question
ATP can also act as a neurotransmitter
Question 8
Question
When concentrations of CA in the synapse are low, Alpha2 Adrenergic receptors are activated,
Question 9
Question
B2 receptors _ adenylate cyclase, which _ the production of cAMP, which _ the influx of ions
Answer
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Stimulates, increases, increases
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Stimulates, increases, decreases
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Inhibits, increases, increases
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Inhibits, decreases, decreases
Question 10
Question
A2 adrenergic receptors have the opposite effect of B2 adrenergic receptors
Question 11
Question
Re-uptake Method 1 is presynaptic, and mediated by what?
Answer
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Active transport
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Diffusion
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A Na+/K+ pump
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Na+ channel
Question 12
Question
Uptake Method 2 is extraneuronal and is used to...
Answer
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Destroy excess adrenaline
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Secrete adrenaline into the bloodstream
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Stimulate separate neurones
Question 13
Question
Monoamine oxidase is found in the RER and interacts with cytoplasmic neurotransmitter
Question 14
Question
What is the role of monoamine oxidase (3 steps)?
Answer
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Converts the amine --> aldehyde
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Reduction of Aldehyde --> Acid
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Reduction of Aldehyde --> Alcohol
Question 15
Question
Which enzyme uses S-Adenosty Methionine to methylate Neurotransmitters?
Question 16
Question
What is the final produce of the Oxidative pathway of Monoamine Oxidase?
Question 17
Question
What is the final produce of the Reductive pathway of Monoamine Oxidase?
Question 18
Question
In peripheral tissue, the oxidative pathway predominates. In the brain, the reduction pathway predominates.