2679692
Descripción
Test por Becca Shaw, actualizado hace más de 1 año
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Creado por Becca Shaw
hace más de 9 años
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Pregunta 1
Pregunta
Drugs are evenly distributed around the body. True or false?
Respuesta
- True
- False
Pregunta 2
Pregunta
Irreversible binding is mainly confined to what?
Respuesta
-
Receptor binding sites
-
Ion channels
-
Enzyme inhibitors
-
Transport/carrier proteins
Pregunta 3
Pregunta
Irreversible binding uses what type of bonding?
Respuesta
-
Covalent
-
Hydrogen
-
Ionic
-
Van der Waals
Pregunta 4
Pregunta
Which of the following are examples of natural binding sites?
Respuesta
-
Receptor binding sites
-
Modulatory sites
-
Allosteric sites
-
Enzyme active sites
Pregunta 5
Pregunta
Modulatory or allosteric sites are a type of separate site to which drugs can bind. True or false?
Respuesta
- True
- False
Pregunta 6
Pregunta
Drugs that block function are known as
Respuesta
-
Antagonists at receptors
-
Inhibitors at transporters/carriers
-
Blockers at ion channels
-
Inhibitors at enymes
Pregunta 7
Pregunta
What is the generic name for Adrenaline?
Respuesta
-
Fluoxetine
-
Noradrenaline
-
Epinephrine
-
Tetracycline
Pregunta 8
Pregunta
What is the generic name for Aspirin?
Respuesta
-
Mefanamic acid
-
Epinephrine
-
Diacetylmorphine
-
Acetylsalicylic acid
Pregunta 9
Pregunta
What is the generic name for Heroin?
Respuesta
-
Fluoxetine
-
Diacetylmorphine
-
Epinephrine
-
Acetylsalicylic acid
Pregunta 10
Pregunta
What is the generic name for Prozac?
Respuesta
-
Fluoxetine
-
Diacetylmorphine
-
Acetylsalicylic acid
-
Mefanamic acid
Pregunta 11
Pregunta
The use of an antagonist on a receptor results in
Respuesta
-
Enzyme activition
-
Opening of ion channels
-
No effect produced
-
Blockage of endognous mediators
Pregunta 12
Pregunta
What direct mechanism would an agonist have on a receptor molecule?
Respuesta
-
Enzyme activation or inhibition
-
Opening or closing of ion channels
-
Modulation of ion channels
-
DNA transcription
Pregunta 13
Pregunta
What transduction mechanisms may occur due to the activity of an agonist on a receptor molecule?
Respuesta
-
Ion channel modulation
-
DNA transcription
-
Enzyme inhibition or activation
-
Opening or closing of ion channel
Pregunta 14
Pregunta
Proteins that bind to specific molecules, called ligands, to produce a response are known as receptors. True or false?
Respuesta
- True
- False
Pregunta 15
Pregunta
When drugs act through receptors, these receptors will always have exogenous ligands. True or false?
Respuesta
- True
- False
Pregunta 16
Pregunta
Examples of endogenous ligands are
Respuesta
-
Hormones
-
Diacetylmorphine
-
Fluoxetine
-
Neurotransmitters
Pregunta 17
Pregunta
The endogenous ligand is always an agonist. True or false?
Respuesta
- True
- False
Pregunta 18
Pregunta
In the absence of ligands, receptors have no other function. True or false?
Respuesta
- True
- False
Pregunta 19
Pregunta
Where are most receptors found?
Respuesta
-
Embedded in the plasma membrane
-
Circulating in the blood
-
Lining the epithelium of the gut
-
In the brain
Pregunta 20
Pregunta
Which of the following statements are true regarding antagonists?
Respuesta
-
They bind loosely to receptors
-
The produce no effect themselves
-
They prevent agonists from binding
-
The block the response
Pregunta 21
Pregunta
Which of the following statements is false regarding Histamine?
Respuesta
-
It is an endogenous agonist
-
Binds to receptors on stomach parietal cells
-
Is an exogenous agonist
-
Causes release of gastric acid
Pregunta 22
Pregunta
Which of the following blocks the parietal histamine receptors?
Respuesta
-
Fluoxetine
-
Acetylcholine
-
Epinephrine
-
Ranitidine
Pregunta 23
Pregunta
Histamine receptor H1 mediates which effect on the gastrointestinal tract?
Respuesta
-
Inflammation
-
Bile secretion
-
Smooth muscle contraction
-
Gastric acid secretion
Pregunta 24
Pregunta
Histamine receptor H2 mediates which effect on the gastrointestinal tract?
Respuesta
-
Inflammation
-
Secretion of gastric acid
-
Bile secretion
-
Smooth muscle contraction
Pregunta 25
Pregunta
Which anatagonist acts upon Histamine receptor H2 to prevent secretion of gastric acid?
Respuesta
-
Ranitidine
-
Epinephrine
-
Acetylsalicylic acid
-
Mepyramine
Pregunta 26
Pregunta
Which antagonist acts upon Histamine receptor H1 to prevent contraction of smooth muscle in parietal cells?
Respuesta
-
Epinephrine
-
Ranitidine
-
Mepyramine
-
Fluoxetine
Pregunta 27
Pregunta
Different receptors for the same endogenous agonist are called subtypes. True or false?
Respuesta
- True
- False
Pregunta 28
Pregunta
Which of the following are a type of receptor family?
Respuesta
-
Ionotropic receptors (ligand-gated ion channels)
-
Kinase-linked receptors
-
Nuclear receptor (cytoplasmic)
-
Metabotropic receptors (G-protein coupled receptors)
Pregunta 29
Pregunta
Which of the following statements are true concerning ionotropic receptors?
Respuesta
-
Channel formed from 3-5 subunits
-
Pore domain of each subunit forms a hydrophobic channel
-
Ligands bind to an intracellular domain
-
Ions flow selectively through the membrane
Pregunta 30
Pregunta
The following is typical of the mechanism of receptors incorporating ion channels: 1. Agonist binds to receptor 2. Change in ion concentration in the cell 3. Depolarisation or hyperpolarisation occurs 4. Cellular effects (response)
Respuesta
- True
- False
Pregunta 31
Pregunta
Nicotinic acetylcholine receptor is a part of the ionotrophic receptor family. True or false?
Respuesta
- True
- False
Pregunta 32
Pregunta
Which of the following statements is false regarding Metabotropic receptors? (G-protein coupled receptors)
Respuesta
-
Consists of a single polypeptide
-
7 transmembrane domains
-
Domains consist of beta helices
-
Ligand binds either to extracellular domain or within transmembrane domain
Pregunta 33
Pregunta
Muscarinic acetylcholine receptors are in the family of metabotropic receptors. True or false?
Respuesta
- True
- False
Pregunta 34
Pregunta
Alpha and beta adrenoceptors are examples of the 2nd messenger effects of GCPRs. True or false?
Respuesta
- True
- False
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