3126972
Pregunta 1
Pregunta
All of the following are correctly matched except?
Respuesta
-
Type I HSR - IgE mediated
-
Type II HSR - IgA mediated
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Type III HSR - Immune complex - IgG mediated
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Type IV HSR - Cell mediated
Pregunta 2
Pregunta
All of the following are true about hygiene hypothesis except
Respuesta
-
Excessive hygeine
-
Overuse of antibiotics
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Not vaccinating the child
Pregunta 3
Pregunta
All of the following are components of a typical adaptive response to an helminthic infection except
Respuesta
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CDH4 Th1 cells
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Cytokines - IL 3,4,5,9,10,13
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antibodies IgE and IgG 1 and 4
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Effector cells such as eosinophils, basophils and mast cells
Pregunta 4
Pregunta
The main components of type I HSR are neutrophils and lymphocytes
Respuesta
- True
- False
Pregunta 5
Pregunta
Sensitization to antigen involves class switching to IgE production on first contact with an allergen
Respuesta
- True
- False
Pregunta 6
Pregunta
All of the following are stages in HSR I except
Respuesta
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Initial exposure to immunogen which results in the production of reactive B and T cells - no symptoms
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B cell - T cell interaction - antigen activation of Th2 cells
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Production of IL 4 + IL 13
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Production of IgE
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Binding of IgE to Fc Epsilon Receptor and activation/sensitization of mast cell and release of mediators
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None of the above
Pregunta 7
Pregunta
The following is true about HSR I immediate and late response
Respuesta
-
Within minutes mast cell + Basophils will release histamine and serotonin causing wheal and flare
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In hours Eosinophils +Th2 will release second wave of mediators prostaglandis and leukotrienes
-
Both are correct
-
None of the above
Pregunta 8
Pregunta
Intrinsic asthma is Type I HSR reaction
Respuesta
- True
- False
Pregunta 9
Pregunta
The Primary method for diagnosing HSR I is by skin testing, with the characteristic response being "wheal and flare" reaction within minutes
Respuesta
- True
- False
Pregunta 10
Pregunta
RAST detects IgG anti-allergen in patient's serum
Respuesta
- True
- False
Pregunta 11
Pregunta
All of the following are used as treatment strategies for HSR I
Respuesta
-
Allergen avoidance
-
Correct Th1/Th2 imbalance (not clinically feasible)
-
Block mediators either with antihistamine, lipoxygenase inhibition or steroid use
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Correct isotype switch to IgE
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Prevent IgE binding to mast cells to prevent IgE mediated degranulation
Pregunta 12
Pregunta
Epinephrine is the main treatment for anaphylaxis - true or false
Respuesta
- True
- False
Pregunta 13
Pregunta
In desensitization treatment the allergen binds to IgG thereby preventing IgE mediated response - true or false
Respuesta
- True
- False
Pregunta 14
Pregunta
Omalizumab is a mab that binds to Fc region of IgE thereby blocking the arming of mast cells - true or false
Respuesta
- True
- False
Pregunta 15
Pregunta
All of the following are true about HSR II except
Respuesta
-
HSR II is mediated by IgG or IgM not IgE
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HSR II the antibodies bind to the self antigen on cell membranes and extracellular matrix
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HSR II makes autoreactive antibodies
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HSR II activates the alternate complement pathway
Pregunta 16
Pregunta
All of the following are mechanisms for cell damage in HSR II except?
Respuesta
-
recruitment of neutrophils - causing tissue injury and inflammation
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Opsonization and Phagocytosis
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Interfere with cellular functions - either block or stimulate cell receptors
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All of the above
-
None of the above
Pregunta 17
Pregunta
All of the following are HSR II reactions except
Respuesta
-
Hemolytic disease of the newborn
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Blood transfusion reactions
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Penicillin reaction
-
Extrinsic asthma
Pregunta 18
Pregunta
All of the following are true regarding Hemolytic disease of the newborn (HDNB) except
Respuesta
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Seen when mother is Rh+ and baby is Rh-
-
Mother is O type blood group and baby A,B or AB
-
Prevention is by giving Rhogam to the mother
-
None of the above
Pregunta 19
Pregunta
All of the following are non cytotoxic type II HSR diseases except
Respuesta
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Myasthenia gravis
-
NDIIM
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Graves disease
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Pernicious anemia
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Penicillin allergy
Pregunta 20
Pregunta
All of the following are cytotoxic HSR II except?
Respuesta
-
Erythroblastosis fetalis (Hemolytic disease of the newborn)
-
PCN reaction
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Rheumatic fever
-
Autoimmune thrombocytopenic purpura
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Goodpasture syndrome
-
Grave's disease
Pregunta 21
Pregunta
Type III HSR - damaged tissues are innocent bystanders when a circulating (soluble antigen) immune complex becomes deposited in the tissues - true or false
Respuesta
- True
- False
Pregunta 22
Pregunta
When immune complexes (ICs) exceed disposal the net result is inflammation locally or systemically - true or false
Respuesta
- True
- False
Pregunta 23
Pregunta
All of the following are Type III HSR except
Respuesta
-
Serum sickness
-
Farmer's lung (Arthus reaction)
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SLE
-
Post Streptococcal glomerulonephritis (PSGN)
-
None of the above
Pregunta 24
Pregunta
Lumpy bumpy pattern of nephritis is characteristic of PSGN - true or false
Respuesta
- True
- False
Pregunta 25
Pregunta
All of the following are true about Arthus reaction except?
Respuesta
-
Farmer's lung is an example of Arthus reaction
-
Arthus reaction is used in the skin testing of HSR III
-
Arthus reactions are visualized in the skin
-
none of the above
Pregunta 26
Pregunta
All of the following are true about delayed type IV HSR except?
Respuesta
-
Starts 49-72 hours after antigen exposure
-
T cell release cytokines that activate macrophages resulting in cell damage
-
B cells form antibodies that are delayed in their response hence called delayed HSR
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Mediated by Th1 cells and CD8+ cytotoxic T cells
Pregunta 27
Pregunta
HSR IV is an inappropriate manifestation of DTH response that normally protects against intracellular bacterial and fungal infections - true or false
Respuesta
- True
- False
Pregunta 28
Pregunta
All of the following are examples of IV HSR except
Respuesta
-
PPD
-
Poison ivy dermatitis
-
contact dermatitis due to nickel exposure
-
Celiac disease
-
PSGN
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