3119940
Question 1
Question
Regarding HIV infection all of the following are true except
Answer
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It is retrovirus that infects CD4 T cells, dendritic cells and macrophages and binds to gp120
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gp 120 changes conformation and binds co-receptors CCR5 and CXCR4
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Reverse transcriptase copies viral ssRNA genomes into ds cDNA
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Replication of HIV occurs in activated T and B cells
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A genetic deficiency of the co-receptor CCR5 confers resistance to HIV infection in vivo
Question 2
Question
All of the following are seen in a typical course of HIV infection except
Answer
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Infected CD4 cells die as a result of viral replication
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There is a latent viral reservoir in the lymphoid tissue
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gp 120 expressed on infected cell binds CD4 on uninfected cell and they fuse forming multinucleated giant cells in HIV infected brain
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Opportunistic infections will begin to arise when CD4 T cell count goes below 400 cell/cubic mm
Question 3
Question
You need 2 positive ELISA and a confirmatory positive Western Blot to confirm HIV positive status
Answer
- True
- False
Question 4
Question
All of the following are true about HIV drugs except?
Answer
-
Block CCR5 - will block fusion
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Block Reverse Transcriptase - Blocks integration
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Block maturation (gp 160 -> gp41)
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HAART (Highly Active Anti-retroviral Therapy) = 1 NRTIs + a PI/NNRTI/II
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