Pathology

Descripción

questions on cell injury and inflammation
ivenkat
Test por ivenkat, actualizado hace más de 1 año
ivenkat
Creado por ivenkat hace más de 9 años
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Resumen del Recurso

Pregunta 1

Pregunta
Permanent tissues (cardiac muscle, skeletal muscle and nerves) cannot undergo hyperplasia, as they do not have stem cells
Respuesta
  • True
  • False

Pregunta 2

Pregunta
Metaplasia is an adaptive change from one ___________________________ cell type to ________________________________-
Respuesta
  • differentiated
  • another differentiated cell type

Pregunta 3

Pregunta
Dysplasia is recognized by the alteration in the ___________________________ of cells and is still ______________________
Respuesta
  • size, shape and arangement
  • reversible

Pregunta 4

Pregunta
All of the following are key drivers of cell injury except?
Respuesta
  • Loss of ATP
  • Increase in cytoplasmic calcium
  • decrease in cytoplasmic calcium
  • Generation of Reactive oxygen species

Pregunta 5

Pregunta
All of the following are conditions where there is hypoxia without ischemia
Respuesta
  • High altitude
  • decreased ventilation
  • decreased Oxygen transfer (ex. emphysema)
  • Polycythemia
  • CO poisoning

Pregunta 6

Pregunta
Loss of ATP in cell injury leads to all of the following except
Respuesta
  • Impairs oxidative phosphorylation
  • Loss of function of Na/K ATPase pump
  • Calcium influx thereby increasing intracytoplasmic calcium
  • Increase in pH causing clumping of chromatin
  • decreased protein synthesis due to ribosomal dysfunction and swelling

Pregunta 7

Pregunta
All of the following result due to increased cytoplasmic calcium in cell injury except?
Respuesta
  • Increased calcium activates phospholipase, protease, endonuclease and ATPase etc
  • It also activates mitochondrial permeability transition pore which results in loss of membrane potential of mitochondria further limiting oxidative phosphorylation
  • Lipid peroxidation and membrane damage
  • None of the above

Pregunta 8

Pregunta
All of the following about ROS is correct except
Respuesta
  • Most potent ROS is O2-
  • H2O2 can act distant from site of production and is the intermediary of hydroxyl radical
  • Peroxynitrite (ONOO-) damages lipids proteins and DNA

Pregunta 9

Pregunta
Which of the following are the morphological changes that are seen in REVERSIBLE cell injury?
Respuesta
  • Cell swelling
  • Cytoplasmic eosinophilia
  • Plasma membrane blebbing
  • Chromatin clumping and redistribution due to decreased pH
  • All of the above
  • None of the above

Pregunta 10

Pregunta
The morphologic hallmark of cell death (irreversible cell injury) is loss of nucleus
Respuesta
  • True
  • False

Pregunta 11

Pregunta
Coagulative necrosis in which tissue becomes a dry, opaque, eosinophilic mass containing the outlines of anucleated cells, resulting from the denaturation of proteins following hypoxia - is seen in all tissues except brain
Respuesta
  • True
  • False

Pregunta 12

Pregunta
Pancreatitis exhibits 2 forms of necrosis they are 1____________________ and 2____________________________
Respuesta
  • Liquefactive
  • Fat

Pregunta 13

Pregunta
Caseous necrosis usually caused by mycobacterial or fungal infections
Respuesta
  • True
  • False

Pregunta 14

Pregunta
The difference between dry and wet gangrene is that dry gangrene is associated with infection whereas the wet gangrene is not
Respuesta
  • True
  • False

Pregunta 15

Pregunta
Resumption of blood supply and oxygenation to ischemic tissue may lead to further injury and tissue destruction
Respuesta
  • True
  • False

Pregunta 16

Pregunta
Necrosis happens to a group of cells which leads to inflammation whereas apoptosis affects single cells marked by shrinkage of the cell, condensation of chromatin, formation of cytoplasmic blebs and fragmentation of the cell into membrane bound apoptotic bodies that are eliminated by phagocytosis
Respuesta
  • True
  • False

Pregunta 17

Pregunta
Regarding apoptosis
Respuesta
  • Anti apoptotic proteins are BCL-2,BCL-XR, MCL1 - keep the Mitochondrial outer membrane impermeable by preventing the leakage of cytochrome c and other death-inducing proteins into the cytosol
  • Pro-apoptotic BAX and BAK upon activation oligomerizes within the outer mitochondrial protein and promote mitochondrial permeability by forming a channel in the outer membrane that allows leakage of cytochrome c from the intermembranous space
  • apoptosis is mediated by caspases - intrinsicpathway by inactivation of BCL-2
  • Extrinsic pathway via FasL-Fas death receptors
  • All of the above are true
  • 1,2 and 4 are true
  • 3,4 are true
  • None of the above

Pregunta 18

Pregunta
Atrophy is a result of decrease in stress which results in decrease in size and or volume of cell mass
Respuesta
  • True
  • False
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