Chapter 2. Protein Composition and Structure

Descripción

Biochemistry
Amy Arce
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Resumen del Recurso

Pregunta 1

Pregunta
What is the function of insulin?
Respuesta
  • Treat diabetes
  • Protein hormone
  • crucial to maintaining salt levels at appropriate levels
  • crucial to maintaining blood sugar at appropriate levels

Pregunta 2

Pregunta
One of the key properties of proteins are?
Respuesta
  • Proteins are perpendicular polymers composed of amino acids
  • proteins have a wide variety of functional groups
  • Proteins can not interact with one another and other macromolecules to form complexes
  • All proteins are rigid and flexible

Pregunta 3

Pregunta
A primary structure is ?
Respuesta
  • Chains of amino acids in a specific sequence
  • Entire chains fold into well defined structures
  • Amino acids close to one another within a sequence can fold into regular structures
  • Composed of multiple polypeptide chains called subunits

Pregunta 4

Pregunta
Alpha helix and beta strands are examples of secondary structures formed by adjacent alpha strands
Respuesta
  • True
  • False

Pregunta 5

Pregunta
Globular proteins such as myoglobin is an example of primary, secondary, tertiary or quaternary structure?
Respuesta
  • Primary
  • Secondary
  • Tertiary
  • Quaternary

Pregunta 6

Pregunta
Hemoglobin is an example of a quaternary structure
Respuesta
  • True
  • False

Pregunta 7

Pregunta
What are the functions of enzymes?
Respuesta
  • Degrades DNA
  • Degrades RNA
  • Catalyst

Pregunta 8

Pregunta
Myofibrils is an example of a protein
Respuesta
  • True
  • False

Pregunta 9

Pregunta
Four classes of amino acids are as followed: [blank_start]Hydrophobic[blank_end] amino acids, [blank_start]Polar[blank_end] amino acids, [blank_start]Positively[blank_end] charged amino acids, and [blank_start]Negatively[blank_end] charged amino acids
Respuesta
  • Hydrophobic
  • Polar
  • Positively
  • Negatively

Pregunta 10

Pregunta
What are the components of an amino acid?
Respuesta
  • Carbon
  • Nitrogen
  • Carboxylic acid
  • Amino group
  • R group
  • L group

Pregunta 11

Pregunta
Only the R isomer is found in proteins
Respuesta
  • True
  • False

Pregunta 12

Pregunta
At neutral pH amino acids primarily exist in the [blank_start]zwitterions[blank_end] form
Respuesta
  • zwitterions

Pregunta 13

Pregunta
Which amino acid is a hydrophobic amino acid?
Respuesta
  • Glycine
  • Serine
  • Arginine
  • Aspartic Acid

Pregunta 14

Pregunta
Positively charged amino acids are
Respuesta
  • Histidine
  • Tyrosine
  • Leucine
  • Arginine
  • Isoleucine
  • Lysine

Pregunta 15

Pregunta
Polar amino acids are
Respuesta
  • Serine
  • Valine
  • Threonine
  • Tyrosine
  • Glutamine
  • Cysteine
  • Methionine
  • Asparagine

Pregunta 16

Pregunta
Negatively charged amino acids consist of [blank_start]Aspartic[blank_end] acid and [blank_start]Glutamic[blank_end] Acid
Respuesta
  • Aspartic
  • Glutamic

Pregunta 17

Pregunta
Phenylalanine, Tryptophan, and Methionine are examples of what amino acid?
Respuesta
  • Polar
  • Positively charged
  • Hydrophobic
  • Negatively charged

Pregunta 18

Pregunta
Glycine, alanine, proline, valine and serine are examples of hydrophobic amino acids
Respuesta
  • True
  • False

Pregunta 19

Pregunta
Peptide bonds are planar
Respuesta
  • True
  • False

Pregunta 20

Pregunta
Amino acids are linked by
Respuesta
  • peptide bonds to form Polypeptide chains
  • alpha helix
  • beta sheets
  • disulfide bonds

Pregunta 21

Pregunta
Most proteins consist of [blank_start]50[blank_end] to [blank_start]2000[blank_end] amino acids
Respuesta
  • 50
  • 2000

Pregunta 22

Pregunta
Polypeptide chain can be cross-linked by sulfide bonds
Respuesta
  • True
  • False

Pregunta 23

Pregunta
Secondary structure
Respuesta
  • Polypeptide chains that fold into regular structures such as alpha helix, and beta sheet
  • Hemoglobin
  • Myoglobin
  • Chains of amino acids in a specific sequence

Pregunta 24

Pregunta
Alpha helix are
Respuesta
  • Coiled structures stabilized by intracain hydrogen bonds
  • Stabilized by hydrogen bonds between polypeptide strands
  • Not as rod like, fully extended not tightly coiled

Pregunta 25

Pregunta
Osteogenesis imperfecta
Respuesta
  • Defect in collagen, Brittle bone disease occurs if a mutation results in the substitution of another amino acid in place of glycine
  • lack of vitamin C preventing hydroxylation of collagen leading to abnormalities in collagen
  • absence of vitamin K leading to proteins not being carboxylated

Pregunta 26

Pregunta
Tertiary structure
Respuesta
  • Refers to spatial arrangement of amino acids that are far apart in the primary structure and to the pattern of disulfide bond formation
  • Can be as simple as two identical polypeptide chains or as complex as dozens of different polypeptide chains
  • Three-dimensional structure formed by hydrogen bonds between peptide NH and CO groups of amino acids that near one another in the primary structure

Pregunta 27

Pregunta
Keratin and collagen are examples of fibrous proteins
Respuesta
  • True
  • False

Pregunta 28

Pregunta
Myoglobin is found within your [blank_start]muscle[blank_end] and [blank_start]binds oxygen[blank_end] on your muscle
Respuesta
  • muscle
  • binds oxygen

Pregunta 29

Pregunta
Quaternary structure
Respuesta
  • Hemoglobin
  • Globular proteins
  • Spatial arrangement of subunits and their nature of their interaction
  • Spatial arrangement of amino acids that are far apart in the primary structure
  • Structure assemble with other chains to form arrays such as the complex of six insulin molecules
  • Myoglobin

Pregunta 30

Pregunta
Hemoglobin is an example of tertiary structure?
Respuesta
  • True
  • False

Pregunta 31

Pregunta
Proteins can be denatured by any treatment that disrupts the weak bonds stabilizing tertiary structure such as
Respuesta
  • Heating
  • Denaturants

Pregunta 32

Pregunta
Scurvy is an example of a disease that results from dysfunctional protein modification and is due to?
Respuesta
  • Lack of vitamin D which prevents hydroxylation of collagen
  • Lack of vitamin C which prevents hydroxylation of collagen leading to abnormalities in collagen
  • due to absence of vitamin K leading to clotting proteins not being carboxylated

Pregunta 33

Pregunta
Hemorrhaging is due to the absence of vitamin K
Respuesta
  • True
  • False

Pregunta 34

Pregunta
Amyloidoses plaques cause disease such as
Respuesta
  • Alzheimer's
  • Parkinson's
  • Huntington's
  • HIV
  • Osteogenesis imperfecta
  • Sickle cell

Pregunta 35

Pregunta
The function of a promoter is to initiate process or transcription
Respuesta
  • True
  • False
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