439530
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace casi 11 años
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Pregunta 1
Pregunta
Of known structures (60-80% of genes) how many are multidomain proteins?
Respuesta
-
40
-
50
-
60
-
30
Pregunta 2
Pregunta
Different combinations of domains are advantageous because they allow the organism to specialise
Respuesta
- True
- False
Pregunta 3
Pregunta
How can we recognize domains?
Respuesta
-
DNA sequencing
-
Amino acid sequencing
-
Structure
-
Topology (fold)
Pregunta 4
Pregunta
Why are DNA/amino acid sequencing of little use when investigating relationships between proteins?
Respuesta
-
As diversion occurs, sequence patterns are lost even as the fold remains the same
-
They can detect short evolutionary relationships only
-
The techniques for reading the sequences are unreliable
-
Identical sequences can give different aa sequences/folds
Pregunta 5
Pregunta
When investigating using structure, how do we identify domains?
Respuesta
-
Amino acid sequence
-
Domains have the same fold
-
The interaction of the protein with other proteins
Pregunta 6
Pregunta
There is a limited number of folds in nature (10^3-4)
Respuesta
- True
- False
Pregunta 7
Pregunta
Structural similarity occurs from what kind of evolution?
Respuesta
-
Divergent
-
Convergent
Pregunta 8
Pregunta
Sequence is more highly conserved than protein structure
Respuesta
- True
- False
Pregunta 9
Pregunta
Define convergent evolution
Respuesta
-
The independent evolution of similar features in different lineages
-
The carrying of a feature from a common ancestor into two lines, which allows the reconvergence of the two lines into a single species again
-
The dependent evolution of similar features in two species that interact/co-operate closely
Pregunta 10
Pregunta
How does the CATH system establish taxonomy?
Respuesta
-
Cut proteins into domains and use computor analysis to group domains
-
Uses structure based analysis
Pregunta 11
Pregunta
Which of the following classifications would be in the Class portion of the CATH system
Respuesta
-
Connectivity of fold
-
Barrel
-
Mostly alpha
Pregunta 12
Pregunta
Which of the following would be in the Architecture domain of the CATH system
Respuesta
-
Mostly beta
-
Both
-
Two layer sandwitch
-
Connectivity of fold
-
Barrel
Pregunta 13
Pregunta
Put the following in order of their use in the CATH system
A- Class
B- Sequence Superfamily
C- Homologous Superfamily
D-Architecture
E- Topology
Respuesta
-
A-D-E-C-B
-
B-A-C-E-D
-
D-E-A-B-C
Pregunta 14
Pregunta
There are 3 classes, 32 architectures and 820 topologies in the CATH system
Respuesta
- True
- False
Pregunta 15
Pregunta
The SCOP classifications, in descending order, are Class-Superfamily-Family-Fold-Species
Respuesta
- True
- False
Pregunta 16
Pregunta
What is the specification after Superfamiy in the Pfam system?
Respuesta
-
Fold
-
Architecture
-
Clade
Pregunta 17
Pregunta
All the systems agree in _% of cases
Respuesta
-
30-40
-
40-50
-
50-60
-
60-70
Pregunta 18
Pregunta
To be homologous, two proteins must have two of which of the following in common?
Respuesta
-
Structural Similarity
-
Sequence Similarity
-
Functional Simiarity
-
Species Similarity
-
Genus Similarity
Pregunta 19
Pregunta
What is the following describing- a protein contained in two different species with a similar function due to divergent evolution
Respuesta
-
Orthologues
-
Paralogues
Pregunta 20
Pregunta
What is the following describing- changes to a sequence following gene duplication leads to a variant copy with an additional (usually similar) function in the same species
Respuesta
-
Orthologues
-
Paralogues
Pregunta 21
Pregunta
Give the two defining features of orthologues
Respuesta
-
RMSD of >4
-
High SI
-
Low SI
-
SI may be high or low
Pregunta 22
Pregunta
NAD is a co-enzyme found in all living cells that accepts and donates electrons
Respuesta
- True
- False
Pregunta 23
Pregunta
NAD is made of three nucleotides and a phosphate group
Respuesta
- True
- False
Pregunta 24
Pregunta
Which of the following binds NAD when present in a protein?
Respuesta
-
A Rossman Fold
-
A Sherman Fold
-
A Fieldman Fold
Pregunta 25
Pregunta
The Rossman Fold has it's 6 beta sheets arranged in what order?
Respuesta
-
654123
-
123456
-
615243
Pregunta 26
Pregunta
In a Rossman fold, the crossover of the strands form the binding site
Respuesta
- True
- False
Pregunta 27
Pregunta
In lactate dehydrogenase, which terminal domain contains the Rossman fold?
Respuesta
-
C
-
N
Pregunta 28
Pregunta
What is the role of the C-terminal domain in dehydrogenases?
Respuesta
-
Enzyme specificity
-
Enzyme regulation
-
Enzyme catalytic activity
Pregunta 29
Pregunta
Lactate dehydrogenase catalyses lactate --> oxaloacetate
Respuesta
- True
- False
Pregunta 30
Pregunta
Malate dehydrogenase is structually identical to LADH, so why do they have different substrates?
Respuesta
-
An SI of 17%
-
They operate in cells where only one or the other is avalible
-
Lactate and malate are structurally identical, but have different components
Pregunta 31
Pregunta
How can we tell two proteins are not homologues?
Respuesta
-
They have a different function
-
They have a different S.I
-
They're found in different species
-
They're structurally different
Pregunta 32
Pregunta
What is the following descrbing- the existence of a shared ancestry between two structures (in this case proteins)
Respuesta
-
Homology
-
Divergent evolution
-
Convergent evolution
Pregunta 33
Pregunta
Alcohol dehydrogenase contains a Rossman fold
Respuesta
- True
- False
Pregunta 34
Pregunta
ADH and LDH have an RMSD of 2.2 & an S.I of 17%- what relationship do they share?
Respuesta
-
Orthologues
-
Paralogues
Pregunta 35
Pregunta
In the case of sequence diversity between proteins, surface residues change less than core/functional site residues
Respuesta
- True
- False
Pregunta 36
Pregunta
Where do residue insertions usually occur?
Respuesta
-
In the functional site
-
In loops connecting secondary structures
-
In alpha helices
Pregunta 37
Pregunta
The functional diversity of a domain superfamily depends on the fold
Respuesta
- True
- False
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