Linkage Analysis

Descripción

Year 2 Test sobre Linkage Analysis, creado por gina_evans0312 el 26/12/2013.
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Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312 hace casi 11 años
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1

Resumen del Recurso

Pregunta 1

Pregunta
Metaphase is the most important stage for genetic mapping
Respuesta
  • True
  • False

Pregunta 2

Pregunta
Recombination cannot be detected in...
Respuesta
  • Homozygotes
  • Heterozygotes
  • Because both alleles are different
  • Because both alleles are identical

Pregunta 3

Pregunta
What indicates linkage?
Respuesta
  • The no of recombinants
  • The no of homozygotes
  • The no of heterozygotes

Pregunta 4

Pregunta
A generation bred from parents AB & ab, has 1 recombinant out of 20- is linkage involved
Respuesta
  • Yes
  • No

Pregunta 5

Pregunta
Recombinant detecting probes can be fooled if double recombination occurs
Respuesta
  • True
  • False

Pregunta 6

Pregunta
Which of the following gametes tend to recombine more around the centromere?
Respuesta
  • Spermatocytes
  • Oocytes

Pregunta 7

Pregunta
Oocytes tend to recombine
Respuesta
  • Around the telomeres
  • Around the centromere
  • More than spermatocytes
  • Less than spermatocytes

Pregunta 8

Pregunta
Most recombination occurs at random
Respuesta
  • True
  • False

Pregunta 9

Pregunta
What is 1q42.3 referring to?
Respuesta
  • Short arm of chromosome 1
  • Long arm of chromosome 1
  • Locus position (from telomere to centromere)
  • Locus position (from centromere to telomere)

Pregunta 10

Pregunta
Meiosis is made informative or uninformative depending on whether you can track the diseased allele
Respuesta
  • True
  • False

Pregunta 11

Pregunta
What must be known for effective meosic analysis?
Respuesta
  • Grandparent -> Grandchild phenotype
  • Grandchild & all siblings phenotype
  • Parent & all siblings -> Grandchild phenotype

Pregunta 12

Pregunta
Is the following informative for linkage analysis?
Respuesta
  • Yes- the child is a recombinant
  • No- the child is heterozygous
  • No- the father is homozygous

Pregunta 13

Pregunta
How would you classify this?
Respuesta
  • Uninformative non-recombinant
  • Informative recombinant
  • Informative Non-recombinant

Pregunta 14

Pregunta
This is an informative recombinant
Respuesta
  • True
  • False

Pregunta 15

Pregunta
What is true of Recombinant/Human Pedigree Analysis?
Respuesta
  • The lower the recombination frequency, the more likely the hypothysis is to be correct
  • The higher the recombination frequency, the more likely the hypothysis is to be correct

Pregunta 16

Pregunta
A mother has a disease, and has the alleles M1 & M2- what are the two hypothesis for pedigree analysis?
Respuesta
  • M1 is diseased M2 is healthy
  • M1 is healthy M2 is diseased
  • M1 & M2 are healthy
  • M1 & M2 are diseased

Pregunta 17

Pregunta
Give the two Recombination frequencies for that above image
Respuesta
  • 0.16 & 0.83
  • 1.66 & 8.33
  • 16.66 & 83.33

Pregunta 18

Pregunta
A higher recombination frequency means alleles are closer together
Respuesta
  • True
  • False

Pregunta 19

Pregunta
Define a Marker
Respuesta
  • Any mendelian character that can be used to follow a disease through a pedigree
  • A fluorescent dye used to find particular alleles
  • A mutagen used to create findable mutations
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