Pregunta 1
Pregunta
What stimulates the secretion of the CA's?
Pregunta 2
Pregunta
Once the membrane has been depolarised, what voltage gated channels open?
Pregunta 3
Pregunta
The influx of ions into the cell signals secretion by exocytosis
Pregunta 4
Pregunta
What is stored in Catecholamine vesicles, along with the CA?
Respuesta
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ATP
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ADP
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Fromogranin
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Chromogranin
Pregunta 5
Pregunta
ATP is -ve at body pH, whilst CA's are +ve
Pregunta 6
Pregunta
Why are CA's stored with these other substances?
Respuesta
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They keep the CA's out of solution
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They keep the CA's in solution
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Which helps prevent vesicle lysis due to osmotic pressure
Pregunta 7
Pregunta
ATP can also act as a neurotransmitter
Pregunta 8
Pregunta
When concentrations of CA in the synapse are low, Alpha2 Adrenergic receptors are activated,
Pregunta 9
Pregunta
B2 receptors _ adenylate cyclase, which _ the production of cAMP, which _ the influx of ions
Respuesta
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Stimulates, increases, increases
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Stimulates, increases, decreases
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Inhibits, increases, increases
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Inhibits, decreases, decreases
Pregunta 10
Pregunta
A2 adrenergic receptors have the opposite effect of B2 adrenergic receptors
Pregunta 11
Pregunta
Re-uptake Method 1 is presynaptic, and mediated by what?
Respuesta
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Active transport
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Diffusion
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A Na+/K+ pump
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Na+ channel
Pregunta 12
Pregunta
Uptake Method 2 is extraneuronal and is used to...
Respuesta
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Destroy excess adrenaline
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Secrete adrenaline into the bloodstream
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Stimulate separate neurones
Pregunta 13
Pregunta
Monoamine oxidase is found in the RER and interacts with cytoplasmic neurotransmitter
Pregunta 14
Pregunta
What is the role of monoamine oxidase (3 steps)?
Respuesta
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Converts the amine --> aldehyde
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Reduction of Aldehyde --> Acid
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Reduction of Aldehyde --> Alcohol
Pregunta 15
Pregunta
Which enzyme uses S-Adenosty Methionine to methylate Neurotransmitters?
Pregunta 16
Pregunta
What is the final produce of the Oxidative pathway of Monoamine Oxidase?
Pregunta 17
Pregunta
What is the final produce of the Reductive pathway of Monoamine Oxidase?
Pregunta 18
Pregunta
In peripheral tissue, the oxidative pathway predominates. In the brain, the reduction pathway predominates.