PT 1

Descripción

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Jon dL
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Jon dL
Creado por Jon dL hace casi 8 años
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Resumen del Recurso

Pregunta 1

Pregunta
The field of immunology expanded along with the development of vaccines. The first widely used vaccine was against the human disease smallpox and was developed from the
Respuesta
  • vaccinia virus
  • variola virus
  • monkeypox virus
  • chickenpox virus

Pregunta 2

Pregunta
The person who coined the term ‘chemotherapy’ and was the first to focus research efforts on the development of drugs to treat infectious disease was
Respuesta
  • Edward Jenner
  • Louis Pasteur
  • Paul Ehrlich
  • Alexander Fleming

Pregunta 3

Pregunta
A “magic bullet” drug to stop HIV replication might be
Respuesta
  • inhibition of nucleic synthesis by Rifamycin
  • inhibition of reverse transcriptase by Lamivudine
  • inhibition of protein synthesis by Streptomycin
  • inhibition of microtubule function by Mebendazole

Pregunta 4

Pregunta
What type of dendritic cell releases CCL 19 and 21 attracting B cells to the lymph nodes?
Respuesta
  • Dendrite
  • APC Dendritic
  • Follicular Dendritic

Pregunta 5

Pregunta
Which complement pathway(s) result in complement fixation?
Respuesta
  • Alternative
  • Lectin
  • Classical
  • All (alternative, lectin, classical)

Pregunta 6

Pregunta
A cell that has a differentiated Heavy (mew) chain and has not yet undergone light chain rearrangement is known as?
Respuesta
  • Pro-B cell
  • Pre-B cell
  • Mature B cell
  • Immature B cell

Pregunta 7

Pregunta
Neutrophils secrete many cytokines.
Respuesta
  • True
  • False

Pregunta 8

Pregunta
Innate immunity is required for adaptive immunity to occur.
Respuesta
  • True
  • False

Pregunta 9

Pregunta
Which of the following is not a granulocyte?
Respuesta
  • Eosinophil
  • Basophil
  • Monocyte
  • Neutrophil

Pregunta 10

Pregunta
A ‘magic bullet’ drug to control an infection with Candida albicans (thrush) or Tinea pedis (athlete’s foot) might target which of the following?
Respuesta
  • Ergosterol
  • 70S ribosomes
  • Peptidoglycan

Pregunta 11

Pregunta
Your 1st defense against infection is
Respuesta
  • Macrophages
  • Neutrophils
  • Skin and mucosal membranes
  • Lymphocytes

Pregunta 12

Pregunta
Which of the following is NOT a phagocyte?
Respuesta
  • Macrophage
  • Neutrophil
  • Dendritic cell
  • Natural Killer cell

Pregunta 13

Pregunta
I am a cell that plays an important role: -in innate immunity -as an antigen presenting cell -in the initiation of adaptive immunity I am a:
Respuesta
  • Basophil
  • Neutrophil
  • Dendritic cell
  • Natural Killer cell

Pregunta 14

Pregunta
An example of a primary lymphoid organ is:
Respuesta
  • Spleen
  • Appendix
  • Thymus
  • Peyer’s patch

Pregunta 15

Pregunta
The success of vaccination relies on development of a good memory response. Immunological memory develops during the __________ immune response and results in higher antibody titers in the __________ response:
Respuesta
  • Innate, primary
  • Innate, secondary
  • Adaptive, primary
  • Adaptive, secondary

Pregunta 16

Pregunta
What is an immediate (first) complement response of our innate immune system to bacterial infection?
Respuesta
  • Classical pathway
  • Lectin pathway
  • Alternative pathway
  • Garden pathway

Pregunta 17

Pregunta
Which complement pathway is activated by antibody?
Respuesta
  • Classical
  • Alternative
  • Lectin
  • All of the above

Pregunta 18

Pregunta
Complement activation results in:
Respuesta
  • Increased opsonization
  • Increased inflammatory response
  • Formation of a membrane attack complex
  • All of the above

Pregunta 19

Pregunta
Cells which are most important in immune surveillance for tumor cells are:
Respuesta
  • TH1 and TH2 cells
  • TH2 and B cells
  • TH1 and B cells
  • NK and CD8 T cells

Pregunta 20

Pregunta
A tumor occurring in a lymph node would be called:
Respuesta
  • Leukemia
  • Sarcoma
  • Lymphoma
  • Carcinoma

Pregunta 21

Pregunta
The Ames test allows detection of:
Respuesta
  • Carcinogens
  • Mutagens
  • Tumors
  • Proto-oncogenes

Pregunta 22

Pregunta
If an autoantibody is made against a cell-surface antigen, the autoimmune disease is considered a:
Respuesta
  • Type I
  • Type II
  • Type III
  • Type IV

Pregunta 23

Pregunta
Autoimmune diseases can be described as:
Respuesta
  • Over-reaction of the human systems to harmless environmental antigens.
  • Under reaction of the immune system to harmless environmental antigens.
  • Gain of tolerance to self-antigens.
  • Loss of tolerance to self-antigens.

Pregunta 24

Pregunta
An example of a minor histocompatibility complex antigen is:
Respuesta
  • XSCID
  • H-Y
  • HVGD
  • H-DR

Pregunta 25

Pregunta
If one wants to minimize the chance of GVHD following a hematopoietic cell transplants, one could administer the cytotoxic drug:
Respuesta
  • Rapamycin
  • Tacrolimus
  • Methotrexate
  • Prednisone

Pregunta 26

Pregunta
The main tissues affected by GVHD are:
Respuesta
  • Skin, liver and GI tract
  • Kidney, liver and heart
  • Skin, kidney and liver
  • Hair, kidney and skin

Pregunta 27

Pregunta
_____ transplants do not require extensive HLA matching, but _____ transplants do.
Respuesta
  • Cornea, liver
  • Heart, cornea
  • Liver, bone marrow
  • Bone marrow, cornea

Pregunta 28

Pregunta
A drug that inhibits IL-2 production is:
Respuesta
  • Azathioprine
  • Tacrolimus
  • Methotrexate
  • Prednisone

Pregunta 29

Pregunta
In dengue infection cross-reactive memory T cells recovered exhibited a higher affinity to variant epitopes representing serotypes of previous exposure – a phenomenon called:
Respuesta
  • Antibody-dependent enhancement
  • ADCC
  • Original antigenic sin
  • Immune complexes

Pregunta 30

Pregunta
Inflammatory cytokine _____ levels have been shown to be higher in DHF than in DF suggesting a role in vascular plasma leakage.
Respuesta
  • IFN-gamma, IL-2
  • TNF-alpha, IL-1
  • IL-10, IL-2
  • IL-6, IL-4

Pregunta 31

Pregunta
The genome of dengue virus is _____ and contains _____ genes.
Respuesta
  • 11 kb; 10
  • 15 kb; 20
  • 20 kb; 30
  • 25 kb; 40

Pregunta 32

Pregunta
Currently DHF and DSS represent _____ of total hospitalized dengue cases.
Respuesta
  • 1-25%
  • 10-50%
  • 2.5-40%
  • 5-220%

Pregunta 33

Pregunta
Dengue virus is a:
Respuesta
  • Filovirus
  • Flavivirus
  • Herpes virus
  • Rhinovirus

Pregunta 34

Pregunta
Anaphylatoxins produced by activated complement include:
Respuesta
  • C4b and C2a
  • C3b and C4a
  • C3a and C5a
  • C2b and C3a

Pregunta 35

Pregunta
Therapeutic monoclonal antibodies can affect the target cell by:
Respuesta
  • Inhibition of calcineurin and induction of apoptosis
  • Inhibit JAK 3 and induction of apoptosis
  • Block or down regulate surface molecules and induction of apoptosis
  • Disrupt DNA replication

Pregunta 36

Pregunta
When a graft is considered to have stable function, treatment is modified from:
Respuesta
  • Xenobiotics to biological
  • Biologicals to maintenance
  • Induction to maintenance
  • Xenobiotics to induction

Pregunta 37

Pregunta
Based on data presented by Andrew Read, the regimen for malaria treatment determined by the WHO actually:
Respuesta
  • Decreases competition by sensitive organisms allowing an increase in resistant organisms in an individual
  • Increase the number of resistant transmission-state organisms
  • Increases transmission of resistant organisms
  • All of the above
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