Pregunta 1
Pregunta
The field of immunology expanded along with the development of vaccines. The first widely used vaccine was against the human disease smallpox and was developed from the
Respuesta
-
vaccinia virus
-
variola virus
-
monkeypox virus
-
chickenpox virus
Pregunta 2
Pregunta
The person who coined the term ‘chemotherapy’ and was the first to focus research efforts on the development of drugs to treat infectious disease was
Respuesta
-
Edward Jenner
-
Louis Pasteur
-
Paul Ehrlich
-
Alexander Fleming
Pregunta 3
Pregunta
A “magic bullet” drug to stop HIV replication might be
Respuesta
-
inhibition of nucleic synthesis by Rifamycin
-
inhibition of reverse transcriptase by Lamivudine
-
inhibition of protein synthesis by Streptomycin
-
inhibition of microtubule function by Mebendazole
Pregunta 4
Pregunta
What type of dendritic cell releases CCL 19 and 21 attracting B cells to the lymph nodes?
Respuesta
-
Dendrite
-
APC Dendritic
-
Follicular Dendritic
Pregunta 5
Pregunta
Which complement pathway(s) result in complement fixation?
Pregunta 6
Pregunta
A cell that has a differentiated Heavy (mew) chain and has not yet undergone light chain rearrangement is known as?
Respuesta
-
Pro-B cell
-
Pre-B cell
-
Mature B cell
-
Immature B cell
Pregunta 7
Pregunta
Neutrophils secrete many cytokines.
Pregunta 8
Pregunta
Innate immunity is required for adaptive immunity to occur.
Pregunta 9
Pregunta
Which of the following is not a granulocyte?
Respuesta
-
Eosinophil
-
Basophil
-
Monocyte
-
Neutrophil
Pregunta 10
Pregunta
A ‘magic bullet’ drug to control an infection with Candida albicans (thrush) or Tinea pedis (athlete’s foot) might target which of the following?
Respuesta
-
Ergosterol
-
70S ribosomes
-
Peptidoglycan
Pregunta 11
Pregunta
Your 1st defense against infection is
Pregunta 12
Pregunta
Which of the following is NOT a phagocyte?
Respuesta
-
Macrophage
-
Neutrophil
-
Dendritic cell
-
Natural Killer cell
Pregunta 13
Pregunta
I am a cell that plays an important role:
-in innate immunity
-as an antigen presenting cell
-in the initiation of adaptive immunity
I am a:
Respuesta
-
Basophil
-
Neutrophil
-
Dendritic cell
-
Natural Killer cell
Pregunta 14
Pregunta
An example of a primary lymphoid organ is:
Respuesta
-
Spleen
-
Appendix
-
Thymus
-
Peyer’s patch
Pregunta 15
Pregunta
The success of vaccination relies on development of a good memory response. Immunological memory develops during the __________ immune response and results in higher antibody titers in the __________ response:
Respuesta
-
Innate, primary
-
Innate, secondary
-
Adaptive, primary
-
Adaptive, secondary
Pregunta 16
Pregunta
What is an immediate (first) complement response of our innate immune system to bacterial infection?
Respuesta
-
Classical pathway
-
Lectin pathway
-
Alternative pathway
-
Garden pathway
Pregunta 17
Pregunta
Which complement pathway is activated by antibody?
Respuesta
-
Classical
-
Alternative
-
Lectin
-
All of the above
Pregunta 18
Pregunta
Complement activation results in:
Pregunta 19
Pregunta
Cells which are most important in immune surveillance for tumor cells are:
Respuesta
-
TH1 and TH2 cells
-
TH2 and B cells
-
TH1 and B cells
-
NK and CD8 T cells
Pregunta 20
Pregunta
A tumor occurring in a lymph node would be called:
Respuesta
-
Leukemia
-
Sarcoma
-
Lymphoma
-
Carcinoma
Pregunta 21
Pregunta
The Ames test allows detection of:
Respuesta
-
Carcinogens
-
Mutagens
-
Tumors
-
Proto-oncogenes
Pregunta 22
Pregunta
If an autoantibody is made against a cell-surface antigen, the autoimmune disease is considered a:
Respuesta
-
Type I
-
Type II
-
Type III
-
Type IV
Pregunta 23
Pregunta
Autoimmune diseases can be described as:
Respuesta
-
Over-reaction of the human systems to harmless environmental antigens.
-
Under reaction of the immune system to harmless environmental antigens.
-
Gain of tolerance to self-antigens.
-
Loss of tolerance to self-antigens.
Pregunta 24
Pregunta
An example of a minor histocompatibility complex antigen is:
Pregunta 25
Pregunta
If one wants to minimize the chance of GVHD following a hematopoietic cell transplants, one could administer the cytotoxic drug:
Respuesta
-
Rapamycin
-
Tacrolimus
-
Methotrexate
-
Prednisone
Pregunta 26
Pregunta
The main tissues affected by GVHD are:
Respuesta
-
Skin, liver and GI tract
-
Kidney, liver and heart
-
Skin, kidney and liver
-
Hair, kidney and skin
Pregunta 27
Pregunta
_____ transplants do not require extensive HLA matching, but _____ transplants do.
Respuesta
-
Cornea, liver
-
Heart, cornea
-
Liver, bone marrow
-
Bone marrow, cornea
Pregunta 28
Pregunta
A drug that inhibits IL-2 production is:
Respuesta
-
Azathioprine
-
Tacrolimus
-
Methotrexate
-
Prednisone
Pregunta 29
Pregunta
In dengue infection cross-reactive memory T cells recovered exhibited a higher affinity to variant epitopes representing serotypes of previous exposure – a phenomenon called:
Pregunta 30
Pregunta
Inflammatory cytokine _____ levels have been shown to be higher in DHF than in DF suggesting a role in vascular plasma leakage.
Respuesta
-
IFN-gamma, IL-2
-
TNF-alpha, IL-1
-
IL-10, IL-2
-
IL-6, IL-4
Pregunta 31
Pregunta
The genome of dengue virus is _____ and contains _____ genes.
Respuesta
-
11 kb; 10
-
15 kb; 20
-
20 kb; 30
-
25 kb; 40
Pregunta 32
Pregunta
Currently DHF and DSS represent _____ of total hospitalized dengue cases.
Respuesta
-
1-25%
-
10-50%
-
2.5-40%
-
5-220%
Pregunta 33
Pregunta
Dengue virus is a:
Respuesta
-
Filovirus
-
Flavivirus
-
Herpes virus
-
Rhinovirus
Pregunta 34
Pregunta
Anaphylatoxins produced by activated complement include:
Respuesta
-
C4b and C2a
-
C3b and C4a
-
C3a and C5a
-
C2b and C3a
Pregunta 35
Pregunta
Therapeutic monoclonal antibodies can affect the target cell by:
Respuesta
-
Inhibition of calcineurin and induction of apoptosis
-
Inhibit JAK 3 and induction of apoptosis
-
Block or down regulate surface molecules and induction of apoptosis
-
Disrupt DNA replication
Pregunta 36
Pregunta
When a graft is considered to have stable function, treatment is modified from:
Pregunta 37
Pregunta
Based on data presented by Andrew Read, the regimen for malaria treatment determined by the WHO actually:
Respuesta
-
Decreases competition by sensitive organisms allowing an increase in resistant organisms in an individual
-
Increase the number of resistant transmission-state organisms
-
Increases transmission of resistant organisms
-
All of the above