DNA Repair Defects & Cancer Therapy

Descripción

Year 2 Fichas sobre DNA Repair Defects & Cancer Therapy, creado por gina_evans0312 el 01/12/2013.
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Fichas por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312 hace casi 11 años
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Resumen del Recurso

Pregunta Respuesta
Xeroderma Pigmentosum Inability to repair pyrimidine dimers caused by UV damage
2 Options for DNA damaged cells Apoptosis, or replication of faulty DNA
Primary Site treatment Surgical Removal
Mesastised Cell Treatment Chemo/radiotherapy
Cytostatic Prevents cell proliferation
Cytotoxic Causes cell destruction
Aim of Cancer treatments Maximum effect on tumor with minimum side effects
Theraputic Window- Cancer therapies sit at the top of the curve
Cell Culture- Primary Cells Essentially normal cells
Cell Culture- Crisis Outside of the body, even in a good environment, most of the cells cannot survive and will die
Cell Culture- Established Cell Line Cells have modified enough to divide indefinitely, but are otherwise normal
Maximum Tolerated Effect Greatest strength of treatment possible without killing the patient
Cell Culture- Transformed Cells Cells are bascially cancerous, but are non-mobile
Cell Culture- Tumerogenic Cells are now mobile and able to metastise
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