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Creado por gina_evans0312
hace más de 10 años
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Pregunta | Respuesta |
Prostoglandin Synthase | Converts Arachidonate to Prostoglandin H2 |
Role of Prostoglandin | Causes inflammation and modulates gastric acid levels |
No of enzyme centres in Prostoglandin synthase | 2 |
Cyclooxygenase | Arachidonic Acid + O2 --> Prostoglandin G2 |
Peroxidase | Prostoglandin G2 --> H20 + Prostoglandin H2 |
Monotopic protein | Attached to the membrane from one side |
Attachment of Prostoglandin synthase | Hydrophobic alpha helices |
Integral/Peripheral | Peripheral, but binds strongly enough to be classed as integral |
Can be detached by... | Detergent |
Location of PS | Inner membrane- as requires substrate of membrane lipid hydrolysis |
Substrate of P.S | Hydrophobic |
Travel of Substrate | Moves through hydrophobic channel in membrane to active site devoid of water |
Binding of aspirin/ibruprofin | Serine 540 |
Enzyme complexes require... | A high degree of subunit communication |
Why have M.E.C's? | Allow specialized function |
Charge | Can prevent M.E.C's forming in the wrong conditions |
Reason for Complex- Product | Product of one enzyme is so reactive/expensive it's better to pass it directly along a complex |
Reason for Complex- Speed | Enzymes are brought closer together and so reactants move between active sites faster |
Reason for Complex- Substrate cycling | Allows cycle to happen so heat can be released |
Positive Collisional Interaction | Two molecules collide and have enough energy to react |
Negative Collisional Interaction | Two molecules collide/don't react due to shape/charge/size issues |
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