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Creado por gina_evans0312
hace más de 10 años
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Pregunta | Respuesta |
Length of Mitochondria target sequence | 10-60 residues |
Residues in Mitochondria target sequence | Alternate- +ve and hydrophobic |
Structure of Mitochondrial Target Sequence | Forms an ampipathic helix- may or may no be cleavable |
Import Pore- TOM40 | 4-8 monomers that form the pore |
Import Pore- TOM22 | Receptor for unfolded protein, and rebinds polypeptide when it's passed the pore to prevent it aggregating |
Import Pore- TOM20/70 | Associated receptors |
Translationally Coupled- TOM20 | Recognizes ampipathic helix of unfolded protein |
Translationally Coupled- Chain of proteins | TOM20-TOM22-TOM5-TOM40 |
(Yeast) Post Translational- MSF | Mitochondrial Import Stimulating Factor |
MSF binds... | Once protein has been folded by ribosomal (yeast) or cytoplasmic (mammals) chaperones |
At pore, MSF interacts with | TOM70, which recognises it |
Carrier proteins | Carry other molecules in and out of mitochondria, and also pass through pore |
TIM23/27 | Forms import pore |
N-terminus of TIM23 | Recognises MSF |
TIM44 | Recruits matrix Hsp70 (and Hsp40/NEF) to TIM complex to fold it as it enters the mitochondria |
Lateral Gate | Allows protein to enter mitochondrial matrix |
Mitochondrial Processing Peptide | Removes mitochondrial targeting factor (cleaves at penultimate residue) |
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