C.tetani

Pregunta	Respuesta
Disease Caused	Tetanus
Source of Bacteria	Dust/soil in wounds
Aerobic or Anaerobic?	All Clostridium are Obligate Anaerobes
Tetanospasmin (Exotoxin) Structure	2 heavy chains, 1 light chain
Tetanospasmin (Exotoxin) Role of Structure	2 heavy chains- bind to nerve terminal, light chain causes effect
Tetanospasmin (Exotoxin) Binding	To gangliosidase Receptors, which endocytose it and release it in the CNS
Tetanospasmin (Exotoxin) Inhibitory Neurones	Taken up by 'muscle relaxing' neurones, where light chain binds snare protein Synaptoprenin
Tetanospasmin (Exotoxin) Effect	Neurotransmitter cannot be release, muscles cannot relax
Symptoms	Lockjaw, arched spin, bent limbs, respiratory spasm
Vaccine	Directed against tetanospasmin
Atoxoid	Inactive toxin that triggers the immune system (found in vaccine)

Resumen del Recurso

	Creado por gina_evans0312 hace más de 10 años