761881
Descripción
Fichas por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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| Pregunta | Respuesta |
| Bacterial Walls- Structure | NAG-NAM chains linked by varying peptide chains |
| Bacterial Walls- Peptide Chains | Bound to NAM, usually with two d-Alas at the end |
| Bacterial Walls- Linking Peptide Chains (Enzyme) | Transpeptidases |
| Bacterial Walls- Linking Peptide Chains (Sequence) | L-Lys of one chain links to the 2nd to last d-Ala of the other (terminal d-Ala is cleaved off) |
| Role of B-Lactams | Prevent Transpeptidation |
| Example | Penicillin |
| Structure of B-Lactams | Almost identical to D-Alanine |
| Effect of Beta-Lacatams | Bind irreversible to transpeptidases so they cannot function, weakening the cell wall, & cause autolysin production which destroys the cell wall |
| Penicillin- Bacteria Effected | Gram +ve (no effect on Gram -ve) |
| Penicillin- Pharmacokinetics (Method of transmission) | Cannot be given orally due to gastic acid |
| Penicillin- Pharmacokinetics (Distribution) | In extracellular fluid |
| Penicillin- Pharmacokinetics (Excretion) | Rapid renal tubular excretion |
| Penicillin- Pharmacokinetics (Half-Life) | Short |
| Penicillin- Drug Reactions (Theraputic Index) | Wide theraputic index |
| Penicillin- Drug Reactions (Allergies) | Can be severe and unrelated to dose |
| Advantage of Procaine Penicillin | Long Half Life |
| Advantage of Penicillin V | Can be given orally |
| Advantage of Amoxycillin | Gram -ve coverage |
| Cephalosporins | Class of Beta Lactams |
| Advantage of Cefuroxine | Gram -ve & +ve coverage |
| Advantage of 3rd Generation Cephalosporins | Gram +ve & -ve coverage, but more effective than Cefuroxine |
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