Creado por gina_evans0312
hace más de 10 años
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Pregunta | Respuesta |
Penicillin | 1st drug used, now resistance in 90% of strains |
Source of Penicillin Resistance | Beta-Lactamases are produced that break down the B-lactam ring |
Methicillin/Cloxacillin | Now used on resistant strains (except MRSA, which is resistant) |
Source of Methacillin/Cloxacillin Resistance | Alteration of Penicillin Binding Protein |
MRSA | Methacillin Resistant Staph. aureus (very nasty) |
SscMec | Mobile genetic element present in MRSA that confers multiple antibiotic resistances |
SscMec Variations | Many, each conferring different combo of resistances |
SscMec (MecA) | MecA codes for altered Penicillin Binding Protein |
SscMec (Insertion Elements) | Part of SsCMec that trap and cluster resistance elements, including macrolytes and others |
SscMecII | Hospital MRSA |
SscMecIV | Community MRSA (much smaller element) |
Treating MRSA- Vancomycin | Targets and removes d-ala to prevent peptide links & blocks transpeptidase |
Treating MRSA- Vancomycin Issues | Same as Gentamycin |
Treating MRSA- Daptomycin | Acts on K+ channels, causing leakage and limiting DNA, RNA & protein function |
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