Creado por gina_evans0312
hace más de 10 años
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Pregunta | Respuesta |
Definition | Blood glucose below 2.2mM |
Effects | Same as cerebral anoxea- blurred vision, lethargy, agitation, mood swings, coma and brain damage |
Alcohol Induced Hypoglycaemia- Effect | Ethanol metabolism in the liver decreases NAD+ availible for glycogenlysis/gluconeogenesis |
Alcohol Induced Hypoglycaemia- Ethanol Dehydrogenase Reaction | Ethanol + NAD --> Acetaldehyde + NADH |
Alcohol Induced Hypoglycaemia- Acetaldehyde Dehydrogenase Reaction | Acetaldehyde + NAD+ --> Acetic Acid + NADH |
Alcohol Induced Hypoglycaemia- NADH Issues | The large vol. of NADH prod. shifts the equilibrium of enzymes that rely on NAD |
Alcohol Induced Hypoglycaemia- Substrate Issue | Very rapid with no control system, there are no substrates left for OAA, DHAP & pyruvate using reactions, so glucose cannot be made |
Alcohol Induced Hypoglycaemia- Acetaldehyde Issues | Very toxic, forming adducts on proteins that prevent function leading to an immune response |
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