Muscle Fatigue

Nota:

• sfd

1. Reversibly decreased of the capacity of a muscle to generate force
   1. Fatigue is induced by the exercise
   2. Principal cause:
      1. -Depletion of muscle glycogen and the reduce capacity to release Ca2+R2
         1. Other cause: high concentration of phosphate, or ADP increased in the cytoplasm.
            1. Inherited Disorders as Duchenne Dystrophy and Mc Ardel Disease
2. Is divided into: Central and peripheral
   1. Central: originate in the Central Nervous System
   2. Peripheral: arises in any neuromuscular junction
3. Muscle damage and repair.
   1. Fiber destruction is detrimental
      1. Skeletal Muscle
         1. produce stem cells called:
            1. Satellite Cells
               1. this cells
                  1. Help the damaged fiber
                  2. Important
                     1. Satellite Cells disappear with oldest age
                  3. Also produce Miostatina
                     1. This protein limits the growth of tissue
                        1. But proteins: titin and nebulin helps muscle