Opioid Analgesics (Narcotics)

Adjunto:

• Opioid Analgesics

1. MOA: affects the response to pain by depressing the reaction

   Adjunto:

   • Pharmokinetics of Opioids

1. resp. depression, nausea, vomitting, constipation, urinary retention, anxiety, dysphoria, dec.HR/BP (stimulate vagus nerve)
2. Addiction Tx: methadone, long acting agonist, cold turkey
3. Overdose: opioid antagonist- naltrexone reverses opioid induced respiratory depression

1. Strength
   1. Strong: morphine, methadone, meperidine, hydromorphone
      1. Moderate: oxycodone,pentazocine,
         1. weak: hydrocodone, codeniene, propoxyphene
            1. Natural: enkephalins, endorphins & dynorphins
2. Receptors
   1. Mu agonists: most common
   2. kappa receptor agonist/mu receptor antagonists
   3. mu receptor antagonists: overdose
3. Structure
   1. morphine & Codiene
   2. Methadone: blocks the high
   3. morphinan: kappa receptors
   4. meperidine